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Aliases for CCDC86 Gene

Aliases for CCDC86 Gene

  • Coiled-Coil Domain Containing 86 2 3 5
  • Cytokine-Induced Protein With Coiled-Coil Domain 3 4
  • Cyclon 3 4
  • Coiled-Coil Domain-Containing Protein 86 3

External Ids for CCDC86 Gene

Previous GeneCards Identifiers for CCDC86 Gene

  • GC11P060367
  • GC11P060609
  • GC11P056955

Summaries for CCDC86 Gene

GeneCards Summary for CCDC86 Gene

CCDC86 (Coiled-Coil Domain Containing 86) is a Protein Coding gene.

Additional gene information for CCDC86 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC86 Gene

Genomics for CCDC86 Gene

GeneHancer (GH) Regulatory Elements for CCDC86 Gene

Promoters and enhancers for CCDC86 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060840 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.6 +1.3 1291 5.9 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A CCDC86 ENSG00000255959 PRPF19 PTGDR2 SLC15A3 GC11P060851 PIR48769 ENSG00000256813
GH11I060871 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 +30.7 30723 2.7 RXRA HLF MAX REST RARA ZFP69B ATF4 ZNF316 NFIC SMARCA4 PIR47747 PRPF19 ENSG00000255959 CCDC86 ENSG00000257052 MS4A10 ENSG00000255845 ZP1
GH11I060774 Enhancer 1 Ensembl ENCODE 11.4 -66.5 -66461 1 SIN3A ZNF2 IRF4 RAD21 RFX5 ZNF143 BCLAF1 SMARCA5 ZNF654 USF2 CCDC86 ENSG00000255959 ENSG00000255845 ENSG00000257052 PRPF19 MS4A10 MS4A15
GH11I060880 Enhancer 0.9 dbSUPER 12.1 +39.1 39065 0.6 FOXA2 MLX ARID4B DMAP1 ZNF48 TCF12 SLC30A9 SP5 MXD4 MIER2 ENSG00000256813 PTGDR2 CCDC86 ENSG00000255959 ENSG00000257052 PRPF19 MS4A18 PIR47747
GH11I060898 Enhancer 0.9 ENCODE dbSUPER 12 +57.5 57532 1.2 CTCF BACH1 RAD21 ZNF316 POLR2A SMC3 ZNF143 NFE2 PRDM10 MAFK CPSF7 TMEM138 RN7SL23P ENSG00000255959 CCDC86 TMEM109 PTGDR2 ENSG00000256813 MS4A10 PRPF19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC86 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC86 gene promoter:

Genomic Locations for CCDC86 Gene

Genomic Locations for CCDC86 Gene
9,133 bases
Plus strand

Genomic View for CCDC86 Gene

Genes around CCDC86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC86 Gene

Proteins for CCDC86 Gene

  • Protein details for CCDC86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 86
    Protein Accession:
    Secondary Accessions:
    • B4DY99

    Protein attributes for CCDC86 Gene

    360 amino acids
    Molecular mass:
    40236 Da
    Quaternary structure:
    • Interacts with hepatitis C virus (HCV) protein NS5A.

    Alternative splice isoforms for CCDC86 Gene


neXtProt entry for CCDC86 Gene

Post-translational modifications for CCDC86 Gene

Other Protein References for CCDC86 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC86 Gene

Domains & Families for CCDC86 Gene

Gene Families for CCDC86 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC86 Gene


Suggested Antigen Peptide Sequences for CCDC86 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC86: view

No data available for UniProtKB/Swiss-Prot for CCDC86 Gene

Function for CCDC86 Gene

Phenotypes From GWAS Catalog for CCDC86 Gene

Gene Ontology (GO) - Molecular Function for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 15607035
genes like me logo Genes that share ontologies with CCDC86: view
genes like me logo Genes that share phenotypes with CCDC86: view

Animal Models for CCDC86 Gene

MGI Knock Outs for CCDC86:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC86 Gene

Localization for CCDC86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC86 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC86 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CCDC86: view

Pathways & Interactions for CCDC86 Gene

SuperPathways for CCDC86 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CCDC86: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC86 Gene

Drugs & Compounds for CCDC86 Gene

No Compound Related Data Available

Transcripts for CCDC86 Gene

mRNA/cDNA for CCDC86 Gene

Unigene Clusters for CCDC86 Gene

Coiled-coil domain containing 86:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC86 Gene

No ASD Table

Relevant External Links for CCDC86 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC86 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC86 Gene

This gene is overexpressed in Lung (28.2) and Peripheral blood mononuclear cells (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC86 Gene

Protein tissue co-expression partners for CCDC86 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC86 Gene:


SOURCE GeneReport for Unigene cluster for CCDC86 Gene:


Evidence on tissue expression from TISSUES for CCDC86 Gene

  • Skin(4.3)
  • Blood(4.2)
  • Liver(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CCDC86: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC86 Gene

Orthologs for CCDC86 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC86 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC86 33 34
  • 98.98 (n)
(Bos Taurus)
Mammalia CCDC86 33
  • 83.62 (n)
-- 34
  • 76 (a)
-- 34
  • 63 (a)
(Rattus norvegicus)
Mammalia Ccdc86 33
  • 77.97 (n)
(Mus musculus)
Mammalia Ccdc86 33 16 34
  • 77.4 (n)
(Canis familiaris)
Mammalia CCDC86 34
  • 66 (a)
(Monodelphis domestica)
Mammalia CCDC86 34
  • 50 (a)
(Gallus gallus)
Aves CCDC86 34
  • 37 (a)
(Anolis carolinensis)
Reptilia CCDC86 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733466 33
  • 65.61 (n)
Str.10541 33
(Danio rerio)
Actinopterygii CCDC86 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14210 34
  • 44 (a)
(Caenorhabditis elegans)
Secernentea Y40B1B.7 34
  • 42 (a)
Species where no ortholog for CCDC86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC86 Gene

Gene Tree for CCDC86 (if available)
Gene Tree for CCDC86 (if available)

Paralogs for CCDC86 Gene Pseudogenes for CCDC86 Gene

genes like me logo Genes that share paralogs with CCDC86: view

No data available for Paralogs for CCDC86 Gene

Variants for CCDC86 Gene

Sequence variations from dbSNP and Humsavar for CCDC86 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000406199 -- 60,851,281(+) T/C downstream_transcript_variant
rs1000583688 -- 60,845,786(+) C/G intron_variant
rs1001491769 -- 60,847,788(+) C/T intron_variant
rs1001640324 -- 60,841,970(+) C/G 5_prime_UTR_variant
rs1001745720 -- 60,850,388(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC86 Gene

Variant ID Type Subtype PubMed ID
nsv952456 CNV deletion 24416366

Variation tolerance for CCDC86 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC86 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC86 Gene

Disorders for CCDC86 Gene

Additional Disease Information for CCDC86

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC86 Gene

Publications for CCDC86 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. (PMID: 17300783) Hoshino A … Fujii H (FEBS letters 2007) 3 4 58
  5. Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. (PMID: 15607035) Ahn J … Hoe KL (Journal of biochemistry and molecular biology 2004) 3 4 58

Products for CCDC86 Gene

Sources for CCDC86 Gene

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