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Aliases for CCDC85C Gene

Aliases for CCDC85C Gene

  • Coiled-Coil Domain Containing 85C 2 3 5

External Ids for CCDC85C Gene

Previous GeneCards Identifiers for CCDC85C Gene

  • GC14M099052
  • GC14M099978
  • GC14M080161

Summaries for CCDC85C Gene

GeneCards Summary for CCDC85C Gene

CCDC85C (Coiled-Coil Domain Containing 85C) is a Protein Coding gene. Diseases associated with CCDC85C include Obstructive Hydrocephalus. An important paralog of this gene is CCDC85A.

UniProtKB/Swiss-Prot for CCDC85C Gene

  • May play an important role in cortical development, especially in the maintenance of radial glia.

Additional gene information for CCDC85C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC85C Gene

Genomics for CCDC85C Gene

GeneHancer (GH) Regulatory Elements for CCDC85C Gene

Promoters and enhancers for CCDC85C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I099594 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558 +3.7 3722 12.1 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CCDC85C HHIPL1 WDR25 CCNK ENSG00000247970 BEGAIN WARS PIR41630
GH14I099560 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 23.7 +35.4 35384 18 HDGF FOXA2 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 CCDC85C CCNK ENSG00000234648 ENSG00000247970 HHIPL1 RPL3P4 EML1 SETD3 GC14P099584 GC14M099518
GH14I099548 Enhancer 0.8 dbSUPER 19.6 +55.2 55153 2 ELF3 FOXA2 ARID4B RAD21 ZSCAN9 RARA THAP11 MIXL1 EGR2 CEBPB CCDC85C ENSG00000247970 HHIPL1 EML1 GC14M099518 GC14P099584
GH14I099550 Enhancer 1.2 ENCODE dbSUPER 10.1 +51.0 51005 6 FOXA2 MLX ZNF493 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 ATF7 YY1 WDR25 CCDC85C GC14M099518 GC14P099584
GH14I099536 Enhancer 1 Ensembl ENCODE dbSUPER 8.3 +66.6 66567 1.8 CTCF ZIC2 SP1 ZFHX2 PATZ1 ZNF143 ZNF600 FOS FOSL2 WT1 GC14M099518 LOC105370661 CCDC85C GC14P099584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC85C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC85C gene promoter:

Genomic Locations for CCDC85C Gene

Genomic Locations for CCDC85C Gene
chr14:99,500,180-99,604,390
(GRCh38/hg38)
Size:
104,211 bases
Orientation:
Minus strand
chr14:99,977,603-100,070,727
(GRCh37/hg19)

Genomic View for CCDC85C Gene

Genes around CCDC85C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC85C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC85C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85C Gene

Proteins for CCDC85C Gene

  • Protein details for CCDC85C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKD9-CC85C_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 85C
    Protein Accession:
    A6NKD9

    Protein attributes for CCDC85C Gene

    Size:
    419 amino acids
    Molecular mass:
    45210 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC85C Gene

Post-translational modifications for CCDC85C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC85C Gene

Domains & Families for CCDC85C Gene

Gene Families for CCDC85C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC85C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC85C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKD9

UniProtKB/Swiss-Prot:

CC85C_HUMAN :
  • Belongs to the CCDC85 family.
Family:
  • Belongs to the CCDC85 family.
genes like me logo Genes that share domains with CCDC85C: view

Function for CCDC85C Gene

Molecular function for CCDC85C Gene

UniProtKB/Swiss-Prot Function:
May play an important role in cortical development, especially in the maintenance of radial glia.

Phenotypes From GWAS Catalog for CCDC85C Gene

Phenotypes for CCDC85C Gene

GenomeRNAi human phenotypes for CCDC85C:
genes like me logo Genes that share phenotypes with CCDC85C: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC85C Gene

Localization for CCDC85C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85C Gene

Cell junction, tight junction. Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC85C gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC85C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction IEA --
GO:0030054 cell junction IEA --
GO:0043296 apical junction complex IEA,ISS --
genes like me logo Genes that share ontologies with CCDC85C: view

Pathways & Interactions for CCDC85C Gene

SuperPathways for CCDC85C Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC85C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0021987 cerebral cortex development IEA,ISS --
genes like me logo Genes that share ontologies with CCDC85C: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC85C Gene

Drugs & Compounds for CCDC85C Gene

No Compound Related Data Available

Transcripts for CCDC85C Gene

mRNA/cDNA for CCDC85C Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC85C Gene

Coiled-coil domain containing 85C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85C Gene

No ASD Table

Relevant External Links for CCDC85C Gene

GeneLoc Exon Structure for
CCDC85C
ECgene alternative splicing isoforms for
CCDC85C

Expression for CCDC85C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC85C Gene

Protein differential expression in normal tissues from HIPED for CCDC85C Gene

This gene is overexpressed in Retina (41.2), Testis (8.9), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC85C Gene



Protein tissue co-expression partners for CCDC85C Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC85C Gene:

CCDC85C

SOURCE GeneReport for Unigene cluster for CCDC85C Gene:

Hs.709288

Evidence on tissue expression from TISSUES for CCDC85C Gene

  • Liver(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCDC85C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC85C Gene

Orthologs for CCDC85C Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC85C 33 34
  • 99.82 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc85c 33
  • 90.57 (n)
mouse
(Mus musculus)
Mammalia Ccdc85c 33 16 34
  • 90.45 (n)
cow
(Bos Taurus)
Mammalia CCDC85C 33 34
  • 90.29 (n)
dog
(Canis familiaris)
Mammalia CCDC85C 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC85C 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC85C 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC85C 33 34
  • 74.54 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC85C 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc85c 33
  • 66.05 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc85ca 33 34
  • 64.91 (n)
ccdc85cb 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17265 33 34
  • 52.23 (n)
worm
(Caenorhabditis elegans)
Secernentea F29G9.2 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4851 34
  • 43 (a)
OneToMany
Species where no ortholog for CCDC85C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC85C Gene

ENSEMBL:
Gene Tree for CCDC85C (if available)
TreeFam:
Gene Tree for CCDC85C (if available)

Paralogs for CCDC85C Gene

Paralogs for CCDC85C Gene

(2) SIMAP similar genes for CCDC85C Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC85C: view

Variants for CCDC85C Gene

Sequence variations from dbSNP and Humsavar for CCDC85C Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000006783 -- 99,536,100(-) C/G/T intron_variant
rs1000007808 -- 99,560,733(-) C/G intron_variant
rs1000101774 -- 99,571,189(-) C/T intron_variant
rs1000116326 -- 99,540,891(-) C/G intron_variant
rs1000130863 -- 99,597,845(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC85C Gene

Variant ID Type Subtype PubMed ID
dgv3885n54 CNV loss 21841781
dgv3886n54 CNV loss 21841781
dgv3887n54 CNV loss 21841781
dgv3888n54 CNV loss 21841781
dgv3889n54 CNV gain+loss 21841781
dgv3890n54 CNV gain 21841781
dgv3891n54 CNV loss 21841781
dgv3892n54 CNV loss 21841781
dgv3893n54 CNV loss 21841781
dgv420e214 CNV loss 21293372
esv2227205 CNV deletion 18987734
esv23792 CNV loss 19812545
esv2749100 CNV deletion 23290073
esv2749101 CNV deletion 23290073
esv3635481 CNV gain 21293372
esv3635485 CNV gain 21293372
nsv1071167 CNV deletion 25765185
nsv1135811 CNV deletion 24896259
nsv1141598 CNV deletion 24896259
nsv1150217 CNV insertion 26484159
nsv1151800 CNV deletion 26484159
nsv456422 CNV loss 19166990
nsv456423 CNV loss 19166990
nsv565732 CNV loss 21841781
nsv565733 CNV gain 21841781
nsv565734 CNV loss 21841781
nsv565735 CNV loss 21841781
nsv565740 CNV loss 21841781
nsv565741 CNV gain 21841781
nsv565747 CNV gain+loss 21841781
nsv565755 CNV loss 21841781
nsv565762 CNV gain 21841781
nsv827050 CNV gain 20364138
nsv827051 CNV gain 20364138
nsv85788 CNV deletion 16902084
nsv952236 CNV deletion 24416366

Variation tolerance for CCDC85C Gene

Gene Damage Index Score: 4.60; 65.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC85C Gene

Human Gene Mutation Database (HGMD)
CCDC85C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC85C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC85C Gene

Disorders for CCDC85C Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC85C Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
obstructive hydrocephalus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC85C

genes like me logo Genes that share disorders with CCDC85C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC85C Gene

Publications for CCDC85C Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for CCDC85C Gene

Sources for CCDC85C Gene

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