Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008] See more...

Aliases for CCDC85B Gene

Aliases for CCDC85B Gene

  • Coiled-Coil Domain Containing 85B 2 3 5
  • DIPA 2 3 4
  • Hepatitis Delta Antigen-Interacting Protein A 3 4
  • Coiled-Coil Domain-Containing Protein 85B 3 4
  • Delta-Interacting Protein A 3 4
  • Hepatitis Delta Antigen Interacting Protein A 2
  • CCDC85B 5

External Ids for CCDC85B Gene

Previous GeneCards Identifiers for CCDC85B Gene

  • GC11P065415
  • GC11P065657
  • GC11P061984

Summaries for CCDC85B Gene

Entrez Gene Summary for CCDC85B Gene

  • Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCDC85B Gene

CCDC85B (Coiled-Coil Domain Containing 85B) is a Protein Coding gene. Diseases associated with CCDC85B include Hepatitis and Separation Anxiety Disorder. An important paralog of this gene is CCDC85C.

UniProtKB/Swiss-Prot Summary for CCDC85B Gene

  • Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity).
  • (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.

Gene Wiki entry for CCDC85B Gene

Additional gene information for CCDC85B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC85B Gene

Genomics for CCDC85B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC85B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065470 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -400.5 -400528 40.1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ATF7 TEAD4 MALAT1 LINC02736 SF1 ZFPL1 POLA2 PCNX3 ENSG00000254855 MUS81 EIF1AD SART1
GH11J065927 Enhancer 1.1 FANTOM5 ENCODE 12.4 +37.6 37572 2.4 SP1 LEF1 ZNF143 MTA2 MTA1 IKZF2 TRIM22 POLR2A YY1 EED EIF1AD CST6 FIBP CCDC85B CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11J065945 Promoter/Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 11.2 +55.0 55002 1.5 GATAD2A RFX1 POLR2A CEBPA SCRT2 MNT FOXP1 SMAD4 RARA TAF1 LOC105369350 TSGA10IP EIF1AD C11orf68 DRAP1 FOSL1 BANF1 CST6 CTSW EFEMP2
GH11J065940 Enhancer 0.9 ENCODE 11.7 +50.7 50695 2 LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 ZNF24 MTA1 BRD9 DPF2 SART1 C11orf68 DRAP1 FOSL1 FIBP CCDC85B CTSW EFEMP2 CFL1 BANF1
GH11J065934 Enhancer 0.6 Ensembl 12.4 +44.0 44028 0.6 DPF2 SOX6 CEBPA CEBPB ZBTB11 TRIM24 CUX1 STAT5A FOXM1 VEZF1 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 PACS1 ENSG00000255320
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC85B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC85B

Top Transcription factor binding sites by QIAGEN in the CCDC85B gene promoter:
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • p300
  • p53
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for CCDC85B Gene

Genomic Locations for CCDC85B Gene
chr11:65,890,673-65,891,635
(GRCh38/hg38)
Size:
963 bases
Orientation:
Plus strand
chr11:65,657,875-65,659,106
(GRCh37/hg19)
Size:
1,232 bases
Orientation:
Plus strand

Genomic View for CCDC85B Gene

Genes around CCDC85B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC85B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC85B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85B Gene

Proteins for CCDC85B Gene

  • Protein details for CCDC85B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15834-CC85B_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 85B
    Protein Accession:
    Q15834
    Secondary Accessions:
    • B2R598
    • Q96HA0

    Protein attributes for CCDC85B Gene

    Size:
    202 amino acids
    Molecular mass:
    22091 Da
    Quaternary structure:
    • Interacts with CEBPB (By similarity). Interacts with EURL (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1 (PubMed:17014843). Interacts with TCF7L2; competes with CTNNB1 (PubMed:17873903). Interacts with ANKRD26 (PubMed:22666460). Interacts with the beta-catenin family proteins ARVCF, CTNND1, CTNND2 AND PKP4 (PubMed:25009281).
    • (Microbial infection) Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG); this interaction affects hepatitis delta virus (HDV) genomic replication in intact cells.
    Miscellaneous:
    • May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.

neXtProt entry for CCDC85B Gene

Post-translational modifications for CCDC85B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC85B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC85B Gene

Domains & Families for CCDC85B Gene

Gene Families for CCDC85B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC85B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC85B Gene

GenScript: Design optimal peptide antigens:
  • Hepatitis delta antigen-interacting protein A (CC85B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15834

UniProtKB/Swiss-Prot:

CC85B_HUMAN :
  • Belongs to the CCDC85 family.
Family:
  • Belongs to the CCDC85 family.
genes like me logo Genes that share domains with CCDC85B: view

Function for CCDC85B Gene

Molecular function for CCDC85B Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.
UniProtKB/Swiss-Prot Induction:
Up-regulated by doxorubicin.

Phenotypes From GWAS Catalog for CCDC85B Gene

Gene Ontology (GO) - Molecular Function for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC85B: view
genes like me logo Genes that share phenotypes with CCDC85B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC85B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC85B Gene

Localization for CCDC85B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85B Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, adherens junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC85B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17014843
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 17014843
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC85B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC85B Gene

Pathways & Interactions for CCDC85B Gene

PathCards logo

SuperPathways for CCDC85B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA 17873903
GO:0040008 regulation of growth IEA --
GO:0045599 negative regulation of fat cell differentiation IEA,ISS --
genes like me logo Genes that share ontologies with CCDC85B: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC85B Gene

Drugs & Compounds for CCDC85B Gene

No Compound Related Data Available

Transcripts for CCDC85B Gene

mRNA/cDNA for CCDC85B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC85B

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85B Gene

No ASD Table

Relevant External Links for CCDC85B Gene

GeneLoc Exon Structure for
CCDC85B

Expression for CCDC85B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC85B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC85B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC85B

SOURCE GeneReport for Unigene cluster for CCDC85B Gene:

Hs.66713

mRNA Expression by UniProt/SwissProt for CCDC85B Gene:

Q15834-CC85B_HUMAN
Tissue specificity: Widely expressed including liver.

Evidence on tissue expression from TISSUES for CCDC85B Gene

  • Skin(4.5)
  • Muscle(4.2)
  • Nervous system(3.6)
  • Lung(3.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CCDC85B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC85B Gene

Orthologs for CCDC85B Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC85B 30 31
  • 99.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC85B 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC85B 30 31
  • 93.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc85b 30
  • 90.76 (n)
Mouse
(Mus musculus)
Mammalia Ccdc85b 30 17 31
  • 90.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC85B 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc85b 30
  • 59.82 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc85b 30 31
  • 62.26 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG17265 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F29G9.2 31
  • 10 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4851 31
  • 33 (a)
OneToMany
Species where no ortholog for CCDC85B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCDC85B Gene

ENSEMBL:
Gene Tree for CCDC85B (if available)
TreeFam:
Gene Tree for CCDC85B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC85B: view image

Paralogs for CCDC85B Gene

Paralogs for CCDC85B Gene

(2) SIMAP similar genes for CCDC85B Gene using alignment to 1 proteins:

  • CC85B_HUMAN
genes like me logo Genes that share paralogs with CCDC85B: view

Variants for CCDC85B Gene

Additional dbSNP identifiers (rs#s) for CCDC85B Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC85B Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for CCDC85B Gene

Gene Damage Index Score: 1.19; 23.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC85B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC85B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC85B Gene

Disorders for CCDC85B Gene

MalaCards: The human disease database

(4) MalaCards diseases for CCDC85B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatitis
  • hepatitis a
separation anxiety disorder
  • separation anxiety disorder of childhood
relapsing fever
hydrocephalus
  • hydrocephalus, nonsyndromic, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CCDC85B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC85B Gene

Publications for CCDC85B Gene

  1. Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PMID: 17873903) Iwai A … Shimotohno K (Oncogene 2008) 2 3 4
  2. A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PMID: 8810253) Brazas R … Ganem D (Science (New York, N.Y.) 1996) 2 3 4
  3. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. (PMID: 22666460) Liu XF … Pastan I (PloS one 2012) 3 4
  4. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PMID: 17014843) Du X … Greene MI (Experimental and molecular pathology 2006) 3 4
  5. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PMID: 15644333) Bezy O … Amri EZ (The Journal of biological chemistry 2005) 2 3

Products for CCDC85B Gene

  • Biorbyt antibodies for CCDC85B

Sources for CCDC85B Gene