Aliases for CCDC85B Gene
Aliases for CCDC85B Gene
External Ids for CCDC85B Gene
- HGNC: 24926
- Entrez Gene: 11007
- Ensembl: ENSG00000175602
- OMIM: 605360
- UniProtKB: Q15834
Previous GeneCards Identifiers for CCDC85B Gene
- GC11P065415
- GC11P065657
- GC11P061984
Summaries for CCDC85B Gene
-
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCDC85B Gene
CCDC85B (Coiled-Coil Domain Containing 85B) is a Protein Coding gene. Diseases associated with CCDC85B include Hepatitis and Leukoencephalopathy With Vanishing White Matter. An important paralog of this gene is CCDC85C.
UniProtKB/Swiss-Prot for CCDC85B Gene
-
Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity).
-
(Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.
Additional gene information for CCDC85B Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC85B Gene
Genomics for CCDC85B Gene
GeneHancer (GH) Regulatory Elements for CCDC85B Gene
Promoters and enhancers for CCDC85B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCDC85B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCDC85B gene promoter:
-
- p53
- p300
- ATF-2
- c-Jun
- C/EBPalpha
- STAT1
- STAT1alpha
- STAT1beta
Regulatory Element Products
Genomic Locations for CCDC85B Gene
Genomic Locations for CCDC85B Gene
- chr11:65,890,112-65,891,635
- (GRCh38/hg38)
- Size:
- 1,524 bases
- Orientation:
- Plus strand
- chr11:65,657,875-65,659,106
- (GRCh37/hg19)
- Size:
- 1,232 bases
- Orientation:
- Plus strand
Genomic View for CCDC85B Gene
Genes around CCDC85B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
CCDC85B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC85B Gene
Proteins for CCDC85B Gene
-
Protein details for CCDC85B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15834-CC85B_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 85B
- Protein Accession:
- Q15834
- B2R598
- Q96HA0
Protein attributes for CCDC85B Gene
- Size:
- 202 amino acids
- Molecular mass:
- 22091 Da
- Quaternary structure:
-
- Interacts with CEBPB (By similarity). Interacts with EURL (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1 (PubMed:17014843). Interacts with TCF7L2; competes with CTNNB1 (PubMed:17873903). Interacts with ANKRD26 (PubMed:22666460).
- (Microbial infection) Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG); this interaction affects hepatitis delta virus (HDV) genomic replication in intact cells.
- Miscellaneous:
-
- May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.
Protein Expression for CCDC85B Gene
Post-translational modifications for CCDC85B Gene
Other Protein References for CCDC85B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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-
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Protein Products
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-
Quality Products:
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-
Abcam proteins for CCDC85B
Assay Products
No data available for DME Specific Peptides for CCDC85B Gene
Domains & Families for CCDC85B Gene
Gene Families for CCDC85B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CCDC85B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15834- Family:
-
- Belongs to the CCDC85 family.
Function for CCDC85B Gene
Molecular function for CCDC85B Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by doxorubicin.
Phenotypes From GWAS Catalog for CCDC85B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for CCDC85B Gene
- GenomeRNAi human phenotypes for CCDC85B:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Lamellipodia cells
Animal Model Products
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-
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC85B
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miRNA for CCDC85B Gene
- miRTarBase miRNAs that target CCDC85B
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CCDC85B
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- genomics-online: cdna clones - Search results for available CCDC85B gene related products
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- Applied Biological Materials Clones for CCDC85B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCDC85B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC85B Gene
Localization for CCDC85B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCDC85B Gene
- Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| extracellular | 3 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 17014843 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 17014843 |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC85B Gene
Pathways & Interactions for CCDC85B Gene
No Data Available
Interacting Proteins for CCDC85B Gene
Selected Interacting proteins:
Q15834-CC85B_HUMAN
ENSP00000311695
for CCDC85B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CCDC85B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0030308 | negative regulation of cell growth | IDA | 17873903 |
| GO:0040008 | regulation of growth | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CCDC85B Gene
Transcripts for CCDC85B Gene
mRNA/cDNA for CCDC85B Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (145) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000312579 1524 bps (uc001ogf.4)
Unigene Clusters for CCDC85B Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC85B
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC85B
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CCDC85B
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- Applied Biological Materials Clones for CCDC85B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CCDC85B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC85B Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC85B Gene:
CCDC85BSOURCE GeneReport for Unigene cluster for CCDC85B Gene:
Hs.66713mRNA Expression by UniProt/SwissProt for CCDC85B Gene:
Q15834-CC85B_HUMAN
Tissue specificity:
Widely expressed including liver.
Evidence on tissue expression from TISSUES for CCDC85B Gene
- Skin(4.3)
- Muscle(4.2)
- Nervous system(3.1)
- Lung(2.6)
Primer Products
-
OriGene qPCR primer pairs for CCDC85B
-
OriGene qPCR primer pairs and template standards for CCDC85B
- genomics-online: primer clones - Search results for available CCDC85B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC85B Gene
Orthologs for CCDC85B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC85B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCDC85B 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCDC85B 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ccdc85b 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccdc85b 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCDC85B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc85b 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccdc85b 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG17265 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F29G9.2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4851 34 |
|
OneToMany |
- Species where no ortholog for CCDC85B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CCDC85B Gene
- ENSEMBL:
- Gene Tree for CCDC85B (if available)
- TreeFam:
- Gene Tree for CCDC85B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCDC85B: view image
Paralogs for CCDC85B Gene
Variants for CCDC85B Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001384988 | -- | 65,888,785(+) | T/A | upstream_transcript_variant | |
| rs1001833034 | -- | 65,888,550(+) | G/T | upstream_transcript_variant | |
| rs1002794877 | -- | 65,889,576(+) | A/C/T | upstream_transcript_variant | |
| rs1003077274 | -- | 65,889,913(+) | T/C | upstream_transcript_variant | |
| rs1003462978 | -- | 65,890,159(+) | CCCCCC/CCCCC | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759834 | CNV | gain | 17122850 |
| nsv1159905 | CNV | duplication | 26073780 |
| nsv555215 | CNV | loss | 21841781 |
| nsv832191 | CNV | loss | 17160897 |
| nsv951019 | CNV | deletion | 24416366 |
Gene Damage Index Score:
1.19;
23.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCDC85B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC85B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC85B Gene
Disorders for CCDC85B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatitis |
|
|
| leukoencephalopathy with vanishing white matter |
|
|
Search CCDC85B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCDC85B
No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC85B Gene
Publications for CCDC85B Gene
- Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PMID: 17873903) Iwai A … Shimotohno K (Oncogene 2008) 2 3 4 58
- A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PMID: 8810253) Brazas R … Ganem D (Science (New York, N.Y.) 1996) 2 3 4 58
- ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. (PMID: 22666460) Liu XF … Pastan I (PloS one 2012) 3 4 58
- DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PMID: 17014843) Du X … Greene MI (Experimental and molecular pathology 2006) 3 4 58
- Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PMID: 15644333) Bezy O … Amri EZ (The Journal of biological chemistry 2005) 2 3 58
Products for CCDC85B Gene
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Sources for CCDC85B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
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