Aliases for CCDC85A Gene

Aliases for CCDC85A Gene

  • Coiled-Coil Domain Containing 85A 2 3 5
  • Coiled-Coil Domain-Containing Protein 85A 3 4
  • KIAA1912 4

External Ids for CCDC85A Gene

Previous GeneCards Identifiers for CCDC85A Gene

  • GC02P056264
  • GC02P056411
  • GC02P056146

Summaries for CCDC85A Gene

GeneCards Summary for CCDC85A Gene

CCDC85A (Coiled-Coil Domain Containing 85A) is a Protein Coding gene. Diseases associated with CCDC85A include Hydrocephalus. An important paralog of this gene is CCDC85C.

UniProtKB/Swiss-Prot Summary for CCDC85A Gene

  • May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family.

Additional gene information for CCDC85A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC85A Gene

Genomics for CCDC85A Gene

GeneHancer (GH) Regulatory Elements for CCDC85A Gene

Promoters and enhancers for CCDC85A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J056183 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 505.4 +1.3 1311 3.8 CTCF TCF12 TEAD4 ZFX ZBTB10 ZBTB26 REST RAD21 CTBP1 ZEB1 ENSG00000233251 CCDC85A LOC100129434 ENSG00000271894
GH02J056229 Enhancer 0.9 Ensembl ENCODE 19.3 +46.3 46271 1.5 JUND ZNF639 ZNF10 ATF2 ZNF148 OSR2 BCL11A ZBTB17 FOS CEBPB CCDC85A ENSG00000233251 RNA5SP93 RF00001-168 piR-43105-354 ENSG00000271894
GH02J056522 Enhancer 0.8 Ensembl ENCODE 17.1 +339.0 339043 1.1 ZSCAN5C REST TRIM28 OSR2 FOSL2 JUND ZNF189 ZNF843 PRDM6 RAD21 LOC101927213 lnc-CCDC85A-1 CCDC85A piR-33605-233
GH02J056474 Enhancer 1 Ensembl ENCODE 10.7 +290.4 290438 2.1 EP300 ZNF639 ZIC2 TRIM28 OSR2 BCL11A WT1 ZBTB17 ZNF184 CEBPB CCDC85A LOC101927213 piR-33605-233
GH02J056447 Enhancer 0.8 ENCODE 10.2 +265.2 265210 3.1 TCF12 TEAD1 ZKSCAN8 OSR2 KMT2B CEBPB ZBTB17 MAFF TFDP1 SAP130 CCDC85A piR-33605-233 LOC101927213
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC85A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC85A

Top Transcription factor binding sites by QIAGEN in the CCDC85A gene promoter:
  • c-Myb
  • C/EBPalpha
  • FOXF2
  • NF-kappaB
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • Sox5
  • Sox9

Genomic Locations for CCDC85A Gene

Genomic Locations for CCDC85A Gene
202,185 bases
Plus strand
202,052 bases
Plus strand

Genomic View for CCDC85A Gene

Genes around CCDC85A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC85A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC85A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85A Gene

Proteins for CCDC85A Gene

  • Protein details for CCDC85A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 85A
    Protein Accession:

    Protein attributes for CCDC85A Gene

    553 amino acids
    Molecular mass:
    59976 Da
    Quaternary structure:
    • May interact with ARVCF; CTNND1; CTNND2 AND PKP4.
    • Sequence=BAB67805.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for CCDC85A Gene

Post-translational modifications for CCDC85A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC85A Gene

No data available for DME Specific Peptides for CCDC85A Gene

Domains & Families for CCDC85A Gene

Gene Families for CCDC85A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC85A Gene


Suggested Antigen Peptide Sequences for CCDC85A Gene

GenScript: Design optimal peptide antigens:
  • CCDC85A protein (A2VDJ7_HUMAN)
  • Coiled-coil domain-containing protein 85A (CC85A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC85 family.
  • Belongs to the CCDC85 family.
genes like me logo Genes that share domains with CCDC85A: view

Function for CCDC85A Gene

Molecular function for CCDC85A Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family.

Phenotypes From GWAS Catalog for CCDC85A Gene

genes like me logo Genes that share phenotypes with CCDC85A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC85A Gene

Localization for CCDC85A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85A Gene

Cell junction, adherens junction.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC85A gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC85A Gene

Pathways & Interactions for CCDC85A Gene

PathCards logo

SuperPathways for CCDC85A Gene

No Data Available

Interacting Proteins for CCDC85A Gene


Gene Ontology (GO) - Biological Process for CCDC85A Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC85A Gene

Drugs & Compounds for CCDC85A Gene

No Compound Related Data Available

Transcripts for CCDC85A Gene

mRNA/cDNA for CCDC85A Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85A Gene

No ASD Table

Relevant External Links for CCDC85A Gene

GeneLoc Exon Structure for

Expression for CCDC85A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC85A Gene

mRNA differential expression in normal tissues according to GTEx for CCDC85A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.0) and Brain - Anterior cingulate cortex (BA24) (x5.4).

Protein differential expression in normal tissues from HIPED for CCDC85A Gene

This gene is overexpressed in Frontal cortex (60.2) and Fetal Brain (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC85A Gene

Protein tissue co-expression partners for CCDC85A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC85A

SOURCE GeneReport for Unigene cluster for CCDC85A Gene:

genes like me logo Genes that share expression patterns with CCDC85A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC85A Gene

Orthologs for CCDC85A Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC85A 31 30
  • 98.73 (n)
(Canis familiaris)
Mammalia CCDC85A 31 30
  • 92.36 (n)
(Mus musculus)
Mammalia Ccdc85a 17 31 30
  • 88.59 (n)
(Rattus norvegicus)
Mammalia Ccdc85a 30
  • 88.56 (n)
(Bos Taurus)
Mammalia CCDC85A 31
  • 86 (a)
(Monodelphis domestica)
Mammalia CCDC85A 31
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC85A 31
  • 75 (a)
(Gallus gallus)
Aves CCDC85A 31 30
  • 77.92 (n)
(Anolis carolinensis)
Reptilia CCDC85A 31
  • 76 (a)
(Danio rerio)
Actinopterygii ccdc85a 31
  • 51 (a)
ccdc85al 31
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17265 31
  • 17 (a)
(Caenorhabditis elegans)
Secernentea F29G9.2 31
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4851 31
  • 45 (a)
Species where no ortholog for CCDC85A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCDC85A Gene

Gene Tree for CCDC85A (if available)
Gene Tree for CCDC85A (if available)
Evolutionary constrained regions (ECRs) for CCDC85A: view image

Paralogs for CCDC85A Gene

Paralogs for CCDC85A Gene

(2) SIMAP similar genes for CCDC85A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC85A: view

Variants for CCDC85A Gene

Additional dbSNP identifiers (rs#s) for CCDC85A Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC85A Gene

Variant ID Type Subtype PubMed ID
esv2211763 CNV deletion 18987734
esv2663248 CNV deletion 23128226
esv2669305 CNV deletion 23128226
esv2720094 CNV deletion 23290073
esv2720096 CNV deletion 23290073
esv2759051 CNV gain 17122850
esv2762648 CNV gain 21179565
esv3575244 CNV gain 25503493
esv3583832 CNV loss 25503493
esv3590879 CNV loss 21293372
esv3590881 CNV loss 21293372
esv3590883 CNV loss 21293372
esv3892459 CNV loss 25118596
nsv1004449 CNV loss 25217958
nsv1123328 CNV deletion 24896259
nsv478291 CNV novel sequence insertion 20440878
nsv522006 CNV loss 19592680
nsv522944 CNV gain 19592680
nsv582032 CNV loss 21841781
nsv829431 CNV gain 20364138
nsv834093 CNV gain 17160897

Variation tolerance for CCDC85A Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC85A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC85A Gene

Disorders for CCDC85A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC85A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • hydrocephalus, nonsyndromic, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC85A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCDC85A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC85A Gene

Publications for CCDC85A Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  2. DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. (PMID: 25009281) Markham NO … Reynolds AB (Molecular biology of the cell 2014) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 41 54
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 54

Products for CCDC85A Gene

Sources for CCDC85A Gene