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Aliases for CCDC84 Gene

Aliases for CCDC84 Gene

  • Coiled-Coil Domain Containing 84 2 3 5
  • Coiled-Coil Domain-Containing Protein 84 3 4
  • DLNB14 3

External Ids for CCDC84 Gene

Previous GeneCards Identifiers for CCDC84 Gene

  • GC11P118377
  • GC11P118868
  • GC11P114808
  • GC11P118998
  • GC11P119011
  • GC11P118999
  • GC11P119001
  • GC11P119004
  • GC11P119006
  • GC11P119008
  • GC11P119009
  • GC11P119010

Summaries for CCDC84 Gene

Entrez Gene Summary for CCDC84 Gene

  • This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CCDC84 Gene

CCDC84 (Coiled-Coil Domain Containing 84) is a Protein Coding gene.

Additional gene information for CCDC84 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC84 Gene

Genomics for CCDC84 Gene

GeneHancer (GH) Regulatory Elements for CCDC84 Gene

Promoters and enhancers for CCDC84 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J118996 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +3.7 3705 3.2 ZNF652 ZFX NKRF POLR2A MLLT1 ZNF121 GTF2F1 ZNF687 ZSCAN21 ZBTB7A CCDC84 CCDC84-DT TRAPPC4 GC11P119013
GH11J118992 Enhancer 0.3 Ensembl 600.7 -1.8 -1752 0.4 ZBTB33 CCDC84 ENSG00000280502 GC11P118997 ENSG00000283691 TRAPPC4 FOXR1
GH11J119090 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 48.3 +99.3 99319 5.9 HDGF MTA3 ZNF652 SP1 ZFX ELF3 CC2D1A MNT ZNF148 NKRF GC11M119097 H2AFX KMT2A HINFP RPL5P30 UBE4A VPS11 CCDC84 BCL9L IFT46
GH11J118433 Promoter/Enhancer 2.5 VISTA EPDnew Ensembl ENCODE dbSUPER 34.6 -556.4 -556383 8.3 SP1 ZFX ELF3 SIX5 CBFA2T2 ZNF148 NKRF MLLT1 POLR2A ZNF687 KMT2A VPS11 HINFP CCDC84 IFT46 TMEM25 ARCN1 THY1 ENSG00000255435 ENSG00000254873
GH11J118906 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.3 -75.6 -75560 24.6 MTA3 ZNF652 SP1 CC2D1A ELF3 ZFX CTCF ZKSCAN8 MNT SIX5 BCL9L UPK2 DPAGT1 CCDC84 ARCN1 ENSG00000245869 VPS11 RNF26 ENSG00000254909 HINFP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC84 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC84 gene promoter:
  • AML1a
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HEN1
  • Roaz
  • RP58

Genomic Locations for CCDC84 Gene

Genomic Locations for CCDC84 Gene
chr11:118,994,353-119,015,793
(GRCh38/hg38)
Size:
21,441 bases
Orientation:
Plus strand
chr11:118,868,852-118,886,501
(GRCh37/hg19)
Size:
17,650 bases
Orientation:
Plus strand

Genomic View for CCDC84 Gene

Genes around CCDC84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC84 Gene

Proteins for CCDC84 Gene

  • Protein details for CCDC84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UT8-CCD84_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 84
    Protein Accession:
    Q86UT8

    Protein attributes for CCDC84 Gene

    Size:
    332 amino acids
    Molecular mass:
    37974 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC84 Gene

Post-translational modifications for CCDC84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC84 Gene

No data available for DME Specific Peptides for CCDC84 Gene

Domains & Families for CCDC84 Gene

Gene Families for CCDC84 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC84 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC84 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 84 (CCD84_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC84: view

No data available for UniProtKB/Swiss-Prot for CCDC84 Gene

Function for CCDC84 Gene

Phenotypes From GWAS Catalog for CCDC84 Gene

genes like me logo Genes that share phenotypes with CCDC84: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC84 - Now 50% OFF >
  • * CCDC84 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC84 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC84 Gene

Localization for CCDC84 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC84 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC84 Gene

Pathways & Interactions for CCDC84 Gene

PathCards logo

SuperPathways for CCDC84 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC84 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC84 Gene

Drugs & Compounds for CCDC84 Gene

No Compound Related Data Available

Transcripts for CCDC84 Gene

mRNA/cDNA for CCDC84 Gene

Unigene Clusters for CCDC84 Gene

Coiled-coil domain containing 84:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC84 - Now 50% OFF >
  • * CCDC84 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC84 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC84 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for CCDC84 Gene

GeneLoc Exon Structure for
CCDC84
ECgene alternative splicing isoforms for
CCDC84

Expression for CCDC84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC84 Gene

Protein differential expression in normal tissues from HIPED for CCDC84 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.9), Cerebrospinal fluid (10.9), and Bone marrow stromal cell (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC84 Gene



Protein tissue co-expression partners for CCDC84 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC84 Gene:

CCDC84

SOURCE GeneReport for Unigene cluster for CCDC84 Gene:

Hs.534613
genes like me logo Genes that share expression patterns with CCDC84: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC84 Gene

Orthologs for CCDC84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC84 35 34
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC84 35 34
  • 90.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC84 35 34
  • 90.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc84 17 35 34
  • 85.14 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc84 34
  • 84.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC84 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC84 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC84 35 34
  • 60.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC84 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc84 34
  • 58.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30684 34
zebrafish
(Danio rerio)
Actinopterygii ccdc84 35 34
  • 56.16 (n)
OneToOne
Species where no ortholog for CCDC84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC84 Gene

ENSEMBL:
Gene Tree for CCDC84 (if available)
TreeFam:
Gene Tree for CCDC84 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC84: view image

Paralogs for CCDC84 Gene

Pseudogenes.org Pseudogenes for CCDC84 Gene

genes like me logo Genes that share paralogs with CCDC84: view

No data available for Paralogs for CCDC84 Gene

Variants for CCDC84 Gene

Sequence variations from dbSNP and Humsavar for CCDC84 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs386352288 uncertain-significance, not provided 119,015,316(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000121364 -- 119,015,770(+) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000313978 -- 118,996,719(+) C/T upstream_transcript_variant
rs1000433036 -- 119,010,632(+) C/A intron_variant
rs1000448558 -- 119,011,864(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC84 Gene

Variant ID Type Subtype PubMed ID
esv3627880 CNV loss 21293372
nsv1127234 CNV deletion 24896259
nsv975231 CNV duplication 23825009
nsv983067 CNV duplication 23825009

Variation tolerance for CCDC84 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC84 Gene

Disorders for CCDC84 Gene

Additional Disease Information for CCDC84

No disorders were found for CCDC84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC84 Gene

Publications for CCDC84 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CCDC84 Gene

Sources for CCDC84 Gene

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