Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC83 Gene

Aliases for CCDC83 Gene

  • Coiled-Coil Domain Containing 83 2 3 5
  • Coiled-Coil Domain-Containing Protein 83 3 4
  • KP-CoT-23 3
  • CT148 3
  • HSD9 3

External Ids for CCDC83 Gene

Previous GeneCards Identifiers for CCDC83 Gene

  • GC11P085244
  • GC11P085566
  • GC11P081863

Summaries for CCDC83 Gene

GeneCards Summary for CCDC83 Gene

CCDC83 (Coiled-Coil Domain Containing 83) is a Protein Coding gene.

Additional gene information for CCDC83 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC83 Gene

Genomics for CCDC83 Gene

GeneHancer (GH) Regulatory Elements for CCDC83 Gene

Promoters and enhancers for CCDC83 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J085854 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 616.6 -0.4 -426 2.5 ZFX ELF3 CEBPG RERE GTF2F1 ZSCAN21 CTCF AHR ZNF24 MAFK CCDC83 ENSG00000279742 SYTL2 CCDC89 CREBZF
GH11J085825 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 625.4 -25.9 -25896 7.4 CTCF NFIB ZSCAN21 NCOA3 MAFK SP7 SP1 PRDM1 FOSL2 CREB1 CCDC83 CCDC89 CREBZF SYTL2 ENSG00000279742
GH11J085889 Enhancer 0.9 Ensembl ENCODE 25.8 +35.0 35046 1.4 MAFK PPARG PRDM1 FOSL2 ZNF600 RXRB ZNF316 JUN JUND FOS CCDC83 ENSG00000255005 AHCYP6
GH11J086060 Promoter/Enhancer 1.8 EPDnew ENCODE dbSUPER 11 +211.1 211124 10.4 ZNF652 SP1 CC2D1A ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF MLLT1 PICALM EED CREBZF LOC100289518 CCDC83 SLC25A1P1
GH11J085808 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.6 -44.6 -44598 3.2 POLR2A EGR1 FOSL2 PKNOX1 ZBTB8A ZNF600 ZIC2 CTCF ZNF629 PATZ1 SYTL2 CCDC83 CCDC89
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC83 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC83 gene promoter:
  • AML1a
  • AP-4
  • E47
  • E4BP4
  • En-1
  • LCR-F1
  • p300
  • Sox5
  • Tal-1

Genomic Locations for CCDC83 Gene

Genomic Locations for CCDC83 Gene
64,967 bases
Plus strand
64,921 bases
Plus strand

Genomic View for CCDC83 Gene

Genes around CCDC83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC83 Gene

Proteins for CCDC83 Gene

  • Protein details for CCDC83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 83
    Protein Accession:
    Secondary Accessions:
    • B2RA49
    • Q6X7T2
    • Q6ZVT5
    • Q8N9Y1

    Protein attributes for CCDC83 Gene

    413 amino acids
    Molecular mass:
    48851 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04154.1; Type=Frameshift; Positions=225; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC83 Gene


neXtProt entry for CCDC83 Gene

Post-translational modifications for CCDC83 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC83 Gene

Domains & Families for CCDC83 Gene

Gene Families for CCDC83 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC83 Gene


Suggested Antigen Peptide Sequences for CCDC83 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 83 (CCD83_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC83: view

No data available for UniProtKB/Swiss-Prot for CCDC83 Gene

Function for CCDC83 Gene

Phenotypes From GWAS Catalog for CCDC83 Gene

Phenotypes for CCDC83 Gene

genes like me logo Genes that share phenotypes with CCDC83: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC83 - Now 50% OFF >
  • * CCDC83 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC83 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC83 Gene

Localization for CCDC83 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC83 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC83 Gene

Pathways & Interactions for CCDC83 Gene

PathCards logo

SuperPathways for CCDC83 Gene

No Data Available

Interacting Proteins for CCDC83 Gene

Gene Ontology (GO) - Biological Process for CCDC83 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC83 Gene

Drugs & Compounds for CCDC83 Gene

No Compound Related Data Available

Transcripts for CCDC83 Gene

mRNA/cDNA for CCDC83 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CCDC83 Gene

Coiled-coil domain containing 83:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC83 - Now 50% OFF >
  • * CCDC83 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC83 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC83 Gene

No ASD Table

Relevant External Links for CCDC83 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC83 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC83 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for CCDC83 Gene

This gene is overexpressed in Gallbladder (43.0), Breast (16.5), and Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC83 Gene

Protein tissue co-expression partners for CCDC83 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC83 Gene:


SOURCE GeneReport for Unigene cluster for CCDC83 Gene:

genes like me logo Genes that share expression patterns with CCDC83: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC83 Gene

Orthologs for CCDC83 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC83 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC83 35 34
  • 99.35 (n)
(Bos Taurus)
Mammalia CCDC83 35 34
  • 86.37 (n)
(Canis familiaris)
Mammalia CCDC83 35 34
  • 85.89 (n)
(Rattus norvegicus)
Mammalia Ccdc83 34
  • 76.69 (n)
(Mus musculus)
Mammalia Ccdc83 17 35 34
  • 75.59 (n)
(Monodelphis domestica)
Mammalia CCDC83 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC83 35
  • 45 (a)
(Gallus gallus)
Aves CCDC83 35 34
  • 56.67 (n)
(Anolis carolinensis)
Reptilia CCDC83 35
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc83 34
  • 50.76 (n)
(Danio rerio)
Actinopterygii ccdc83 35 34
  • 43.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10447 35
  • 29 (a)
Species where no ortholog for CCDC83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC83 Gene

Gene Tree for CCDC83 (if available)
Gene Tree for CCDC83 (if available)
Evolutionary constrained regions (ECRs) for CCDC83: view image

Paralogs for CCDC83 Gene

No data available for Paralogs for CCDC83 Gene

Variants for CCDC83 Gene

Sequence variations from dbSNP and Humsavar for CCDC83 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000044917 -- 85,882,097(+) G/A intron_variant
rs1000059529 -- 85,899,085(+) A/G intron_variant
rs1000091733 -- 85,899,444(+) C/T intron_variant
rs1000126186 -- 85,863,736(+) T/A/C/G genic_upstream_transcript_variant, intron_variant
rs1000205648 -- 85,855,093(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC83 Gene

Variant ID Type Subtype PubMed ID
esv2678670 CNV deletion 23128226
esv2744853 CNV deletion 23290073
esv2759845 CNV gain+loss 17122850
esv3548087 CNV deletion 23714750
esv3627077 CNV loss 21293372
esv3627078 CNV loss 21293372
esv3627079 CNV loss 21293372
nsv1035489 CNV gain 25217958
nsv1053808 CNV gain 25217958
nsv418 CNV insertion 18451855
nsv832222 CNV gain 17160897
nsv975957 CNV duplication 23825009

Variation tolerance for CCDC83 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC83 Gene

Disorders for CCDC83 Gene

Additional Disease Information for CCDC83

No disorders were found for CCDC83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC83 Gene

Publications for CCDC83 Gene

  1. KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in colon cancer. (PMID: 22923163) Song MH … Lee SY (International journal of oncology 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. [Characteristics of a novel human testis-specific gene, HSD-9, and its encoding protein]. (PMID: 17633455) Wang Y … Wang LF (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2007) 3 58

Products for CCDC83 Gene

Sources for CCDC83 Gene

Loading form....