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Aliases for CCDC81 Gene

Aliases for CCDC81 Gene

  • Coiled-Coil Domain Containing 81 2 3 5

External Ids for CCDC81 Gene

Previous GeneCards Identifiers for CCDC81 Gene

  • GC11P085764
  • GC11P086085
  • GC11P082374

Summaries for CCDC81 Gene

GeneCards Summary for CCDC81 Gene

CCDC81 (Coiled-Coil Domain Containing 81) is a Protein Coding gene.

Additional gene information for CCDC81 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC81 Gene

Genomics for CCDC81 Gene

GeneHancer (GH) Regulatory Elements for CCDC81 Gene

Promoters and enhancers for CCDC81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I086374 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 0.0 -30 0.6 CTCF USF1 MAX SIN3A CCDC81 HIKESHI LOC105369421
GH11I086951 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 6.6 +579.6 579625 5.9 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 FZD4 LOC100506368 EED CCDC81 ENSG00000255471 ME3 PRSS23
GH11I086937 Enhancer 1.4 Ensembl ENCODE dbSUPER 7.3 +565.8 565849 5.5 HDGF ATF1 FOXA2 MLX ARNT ARID4B BRCA1 ZNF48 ETS1 YY1 CCDC81 LOC100506368 ENSG00000255471 TMEM135 FZD4 PRSS23
GH11I086201 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -172.1 -172136 2.8 HDGF PKNOX1 ATF1 ARNT IRF4 YY1 POLR2B ZNF766 E2F8 KLF7 PICALM RNU6-560P EED HIKESHI CCDC81 FNTAP1 ENSG00000276669
GH11I086998 Enhancer 1.2 Ensembl ENCODE 6.8 +625.4 625372 2.9 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A E2F8 SP5 NFYC EED LOC100420680 LOC100506368 CCDC81 GC11P086992 GC11M086989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC81 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC81 gene promoter:

Genomic Locations for CCDC81 Gene

Genomic Locations for CCDC81 Gene
chr11:86,374,736-86,423,109
(GRCh38/hg38)
Size:
48,374 bases
Orientation:
Plus strand
chr11:86,085,778-86,134,151
(GRCh37/hg19)

Genomic View for CCDC81 Gene

Genes around CCDC81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC81 Gene

Proteins for CCDC81 Gene

  • Protein details for CCDC81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN84-CCD81_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 81
    Protein Accession:
    Q6ZN84
    Secondary Accessions:
    • A0AVL7
    • Q53FW3
    • Q9H5E5

    Protein attributes for CCDC81 Gene

    Size:
    652 amino acids
    Molecular mass:
    76084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD96888.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC81 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC81 Gene

Post-translational modifications for CCDC81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC81 Gene

No data available for DME Specific Peptides for CCDC81 Gene

Domains & Families for CCDC81 Gene

Gene Families for CCDC81 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC81 Gene

Suggested Antigen Peptide Sequences for CCDC81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC81: view

No data available for UniProtKB/Swiss-Prot for CCDC81 Gene

Function for CCDC81 Gene

Phenotypes From GWAS Catalog for CCDC81 Gene

Gene Ontology (GO) - Molecular Function for CCDC81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with CCDC81: view
genes like me logo Genes that share phenotypes with CCDC81: view

Animal Model Products

miRNA for CCDC81 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC81 Gene

Localization for CCDC81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC81 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC81 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC81: view

Pathways & Interactions for CCDC81 Gene

SuperPathways for CCDC81 Gene

No Data Available

Interacting Proteins for CCDC81 Gene

Gene Ontology (GO) - Biological Process for CCDC81 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC81 Gene

Drugs & Compounds for CCDC81 Gene

No Compound Related Data Available

Transcripts for CCDC81 Gene

Unigene Clusters for CCDC81 Gene

Coiled-coil domain containing 81:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC81 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - - - - - -
SP7:

Relevant External Links for CCDC81 Gene

GeneLoc Exon Structure for
CCDC81
ECgene alternative splicing isoforms for
CCDC81

Expression for CCDC81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC81 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC81 Gene

This gene is overexpressed in Testis (x5.5) and Fallopian Tube (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of CCDC81 Gene:

CCDC81

SOURCE GeneReport for Unigene cluster for CCDC81 Gene:

Hs.144913

Evidence on tissue expression from TISSUES for CCDC81 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with CCDC81: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC81 Gene

Orthologs for CCDC81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC81 33 34
  • 98.93 (n)
dog
(Canis familiaris)
Mammalia CCDC81 33 34
  • 87.3 (n)
cow
(Bos Taurus)
Mammalia CCDC81 33 34
  • 85.02 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc81 33
  • 83.13 (n)
mouse
(Mus musculus)
Mammalia Ccdc81 33 16 34
  • 83 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC81 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC81 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 38 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CCDC81 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc81 33
  • 58.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for CCDC81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC81 Gene

ENSEMBL:
Gene Tree for CCDC81 (if available)
TreeFam:
Gene Tree for CCDC81 (if available)

Paralogs for CCDC81 Gene

No data available for Paralogs for CCDC81 Gene

Variants for CCDC81 Gene

Sequence variations from dbSNP and Humsavar for CCDC81 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000004412 -- 86,404,014(+) C/A intron_variant
rs1000037305 -- 86,423,573(+) C/A/T downstream_transcript_variant
rs1000291200 -- 86,403,643(+) G/A intron_variant
rs1000368431 -- 86,417,747(+) TTTTTTTTTTT/TTTTTTTTTT intron_variant
rs1000380323 -- 86,397,075(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC81 Gene

Variant ID Type Subtype PubMed ID
esv3627087 CNV loss 21293372

Variation tolerance for CCDC81 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC81

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC81 Gene

Disorders for CCDC81 Gene

Additional Disease Information for CCDC81

No disorders were found for CCDC81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC81 Gene

Publications for CCDC81 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 58
  2. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan LC … Rothenberg ME (Nature genetics 2014) 3 58
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CCDC81 Gene

Sources for CCDC81 Gene

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