Aliases for CCDC81 Gene
Aliases for CCDC81 Gene
External Ids for CCDC81 Gene
- HGNC: 26281
- Entrez Gene: 60494
- Ensembl: ENSG00000149201
- UniProtKB: Q6ZN84
Previous GeneCards Identifiers for CCDC81 Gene
- GC11P085764
- GC11P086085
- GC11P082374
Summaries for CCDC81 Gene
GeneCards Summary for CCDC81 Gene
CCDC81 (Coiled-Coil Domain Containing 81) is a Protein Coding gene.
Additional gene information for CCDC81 Gene
- Monarch Initiative
- Search for CCDC81 at DataMed
- Search for CCDC81 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC81 Gene
Genomics for CCDC81 Gene
GeneHancer (GH) Regulatory Elements for CCDC81 Gene
Promoters and enhancers for CCDC81 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J086374 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE | 650.7 | 0.0 | -30 | 0.6 | CTCF USF1 MAX SIN3A | CCDC81 HIKESHI LOC105369421 | |
| GH11J086394 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 650.3 | +21.0 | 21021 | 1.9 | JUND TRIM28 | CCDC81 PTP4A1P6 | |
| GH11J086337 | Promoter | 0.5 | EPDnew | 650.3 | -37.3 | -37280 | 0.1 | CCDC81 HIKESHI RN7SL225P LOC105369421 | ||
| GH11J086951 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE dbSUPER | 6.6 | +579.6 | 579625 | 5.9 | HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 | LOC100506368 FZD4 TMEM135 CCDC81 ENSG00000255471 ME3 PRSS23 | |
| GH11J086937 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 7.3 | +565.8 | 565849 | 5.5 | HDGF FOXA2 MLX ARNT ARID4B YY1 POLR2B ZNF766 ZNF143 SP5 | CCDC81 LOC100506368 ENSG00000255471 TMEM135 FZD4 PRSS23 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCDC81 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCDC81 gene promoter:
-
- POU6F1 (c2)
- AP-1
- RSRFC4
- HEN1
- E2F-1
- E2F
- Hlf
- NF-E2 p45
- NF-E2
- Cart-1
Regulatory Element Products
Genomic Locations for CCDC81 Gene
Genomic Locations for CCDC81 Gene
- chr11:86,374,736-86,423,109
- (GRCh38/hg38)
- Size:
- 48,374 bases
- Orientation:
- Plus strand
- chr11:86,085,778-86,134,151
- (GRCh37/hg19)
- Size:
- 48,374 bases
- Orientation:
- Plus strand
Genomic View for CCDC81 Gene
Genes around CCDC81 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q14.2 by Entrez Gene
- 11q14.2 by HGNC
- 11q14.2 by Ensembl
CCDC81 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC81 Gene
Proteins for CCDC81 Gene
-
Protein details for CCDC81 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZN84-CCD81_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 81
- Protein Accession:
- Q6ZN84
- A0AVL7
- Q53FW3
- Q9H5E5
Protein attributes for CCDC81 Gene
- Size:
- 652 amino acids
- Molecular mass:
- 76084 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAD96888.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for CCDC81 Gene
Other Protein References for CCDC81 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC81
- Novus Biologicals Antibodies for CCDC81
- Invitrogen Antibodies for CCDC81
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-
Boster Bio Antibodies for CCDC81
Protein Products
-
OriGene Purified Proteins for CCDC81
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- Search GeneTex for Proteins for CCDC81
Assay Products
No data available for DME Specific Peptides for CCDC81 Gene
Domains & Families for CCDC81 Gene
Gene Families for CCDC81 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CCDC81 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC81 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CCDC81 Gene
Function for CCDC81 Gene
Phenotypes From GWAS Catalog for CCDC81 Gene
Phenotypes for CCDC81 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
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- Overview of 88 available CCDC81 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC81
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miRNA for CCDC81 Gene
- miRTarBase miRNAs that target CCDC81
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 88 available CCDC81 gene related products
- Overview of 88 available CCDC81 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CCDC81
- VectorBuilder custom plasmid, inducible vectors for CCDC81
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC81
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC81
- Applied Biological Materials Clones for CCDC81
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCDC81
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC81 Gene
Localization for CCDC81 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCDC81 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytosol | 2 |
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 25074808 |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Transcripts for CCDC81 Gene
mRNA/cDNA for CCDC81 Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000354755 2510 bps (uc001pbw.3)
- ENST00000445632 2528 bps (uc001pbx.3)
- ENST00000525247 1511 bps (uc058ggm.1)
- ENST00000528728 1814 bps (uc001pby.3)
- ENST00000529603 550 bps (uc058ggk.1)
Unigene Clusters for CCDC81 Gene
- Coiled-coil domain containing 81:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CCDC81
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC81
- genomics-online: gRNA clones - Search results for 88 available CCDC81 gene related products
- Overview of 88 available CCDC81 gene related products
- Applied Biological Materials CRISPR for CCDC81
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC81
- GenScript: Design CRISPR guide RNA sequences for CCDC81
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC81
- Browse OriGene Inhibitory RNA Products For CCDC81
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC81
- genomics-online: shRNA clones - Search results for 88 available CCDC81 gene related products
- Overview of 88 available CCDC81 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CCDC81
- VectorBuilder custom plasmid, inducible vectors for CCDC81
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC81
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC81
- Applied Biological Materials Clones for CCDC81
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for CCDC81 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
- Mesenchymal Stem Cells
- NULL (Uncategorized)
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for CCDC81 Gene
This gene is overexpressed in Testis (x5.5) and Fallopian Tube (x5.5).
NURSA nuclear receptor signaling pathways regulating expression of CCDC81 Gene:
CCDC81SOURCE GeneReport for Unigene cluster for CCDC81 Gene:
Hs.144913Evidence on tissue expression from TISSUES for CCDC81 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for CCDC81
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC81 Gene
Orthologs for CCDC81 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC81 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCDC81 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCDC81 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ccdc81 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccdc81 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCDC81 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC81 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | CCDC81 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc81 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for CCDC81 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CCDC81 Gene
- ENSEMBL:
- Gene Tree for CCDC81 (if available)
- TreeFam:
- Gene Tree for CCDC81 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCDC81: view image
Paralogs for CCDC81 Gene
No data available for Paralogs for CCDC81 Gene
Variants for CCDC81 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004412 | -- | 86,404,014(+) | C/A | intron_variant | |
| rs1000037305 | -- | 86,423,573(+) | C/A/T | downstream_transcript_variant | |
| rs1000291200 | -- | 86,403,643(+) | G/A | intron_variant | |
| rs1000368431 | -- | 86,417,747(+) | TTTTTTTTTTT/TTTTTTTTTT | intron_variant | |
| rs1000380323 | -- | 86,397,075(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3627087 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.81;
73.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCDC81 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC81
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC81 Gene
Disorders for CCDC81 Gene
Additional Disease Information for CCDC81
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CCDC81 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC81 Gene
Publications for CCDC81 Gene
- Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 58
- Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan LC … Rothenberg ME (Nature genetics 2014) 3 58
- Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
Products for CCDC81 Gene
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- Custom Antibody ServicesOriGene Antibodies for CCDC81
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- VectorBuilder custom plasmid, inducible vectors for CCDC81
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC81
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available CCDC81 related products ranked by validation data
- antibodies-online: Search results for available CCDC81 related products ranked by validation data
- antibodies-online: Search results for available CCDC81 related products ranked by validation data
- GeneTex CCDC81 Antibody for CCDC81
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- Horizon Cell Lines for CCDC81
- genomics-online: cdna clones - Search results for 88 available CCDC81 gene related products
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- Overview of 88 available CCDC81 gene related products
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- Overview of 88 available CCDC81 gene related products
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- Overview of 88 available CCDC81 gene related products
- genomics-online: shRNA clones - Search results for 88 available CCDC81 gene related products
- Overview of 88 available CCDC81 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC81
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- Boster Bio Antibodies for CCDC81
- Browse Boster Bio ELISA Kits
Sources for CCDC81 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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