Aliases for CCDC81 Gene

Aliases for CCDC81 Gene

  • Coiled-Coil Domain Containing 81 2 3 5
  • Coiled-Coil Domain-Containing Protein 81 3 4
  • FLJ16339 2
  • FLJ23514 2
  • CCDC81 5

External Ids for CCDC81 Gene

Previous GeneCards Identifiers for CCDC81 Gene

  • GC11P085764
  • GC11P086085
  • GC11P082374

Summaries for CCDC81 Gene

GeneCards Summary for CCDC81 Gene

CCDC81 (Coiled-Coil Domain Containing 81) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC81 Gene

Genomics for CCDC81 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J086374 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 64 1.2 SIN3A TAF1 ZMYM3 USF1 RFX3 CCDC81 HIKESHI HSALNG0086233 ME3
GH11J086395 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 259.2 +20.9 20865 3.2 SPI1 JUND CCDC81 HSALNG0086237 piR-41141-005 ME3
GH11J086337 Promoter 0.3 EPDnew 250.3 -37.3 -37280 0.1 HSALNG0086234 CCDC81 HIKESHI RN7SL225P RF00017-1001 lnc-ME3-3 LOC105369421 NONHSAG009271.2 HSALNG0086233
GH11J086375 Enhancer 0.3 Ensembl 250.7 +1.1 1065 0.4 ZMYM3 CCDC81 HSALNG0086233 ME3
GH11J086953 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.6 +579.8 579791 5.6 CHD2 TBP ZBTB10 MXD4 CEBPA MNT IKZF1 SMAD5 ZFP64 ZNF217 FZD4 FZD4-DT HSALNG0086259 TMEM135 CCDC81 ENSG00000255471 ME3 NONHSAG009279.2 PRSS23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC81 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC81

Top Transcription factor binding sites by QIAGEN in the CCDC81 gene promoter:
  • AP-1
  • Cart-1
  • E2F
  • E2F-1
  • HEN1
  • Hlf
  • NF-E2
  • NF-E2 p45
  • POU6F1 (c2)
  • RSRFC4

Genomic Locations for CCDC81 Gene

Latest Assembly
chr11:86,374,736-86,424,908
(GRCh38/hg38)
Size:
50,173 bases
Orientation:
Plus strand

Previous Assembly
chr11:86,085,929-86,134,148
(GRCh37/hg19 by Entrez Gene)
Size:
48,220 bases
Orientation:
Plus strand

chr11:86,085,778-86,134,151
(GRCh37/hg19 by Ensembl)
Size:
48,374 bases
Orientation:
Plus strand

Genomic View for CCDC81 Gene

Genes around CCDC81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC81 Gene

Proteins for CCDC81 Gene

  • Protein details for CCDC81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN84-CCD81_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 81
    Protein Accession:
    Q6ZN84
    Secondary Accessions:
    • A0AVL7
    • Q53FW3
    • Q9H5E5

    Protein attributes for CCDC81 Gene

    Size:
    652 amino acids
    Molecular mass:
    76084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD96888.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC81 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC81 Gene

Post-translational modifications for CCDC81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC81 Gene

Domains & Families for CCDC81 Gene

Gene Families for CCDC81 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC81 Gene

Suggested Antigen Peptide Sequences for CCDC81 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 81 (CCD81_HUMAN)
genes like me logo Genes that share domains with CCDC81: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC81 Gene

Function for CCDC81 Gene

Phenotypes From GWAS Catalog for CCDC81 Gene

Gene Ontology (GO) - Molecular Function for CCDC81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21930792
genes like me logo Genes that share ontologies with CCDC81: view
genes like me logo Genes that share phenotypes with CCDC81: view

miRNA for CCDC81 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC81

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC81 Gene

Localization for CCDC81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC81 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC81 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IBA,IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC81: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC81 Gene

Pathways & Interactions for CCDC81 Gene

PathCards logo

SuperPathways for CCDC81 Gene

No Data Available

Interacting Proteins for CCDC81 Gene

Selected Interacting proteins: Q6ZN84-CCD81_HUMAN for CCDC81 Gene via UniProtKB

Symbol External ID(s) Details
SCIMP

Gene Ontology (GO) - Biological Process for CCDC81 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC81 Gene

Drugs & Compounds for CCDC81 Gene

No Compound Related Data Available

Transcripts for CCDC81 Gene

mRNA/cDNA for CCDC81 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC81

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC81 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - - - - - -
SP7:

Relevant External Links for CCDC81 Gene

GeneLoc Exon Structure for
CCDC81

Expression for CCDC81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC81 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC81 Gene

This gene is overexpressed in Testis (x5.5) and Fallopian Tube (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC81

SOURCE GeneReport for Unigene cluster for CCDC81 Gene:

Hs.144913

Evidence on tissue expression from TISSUES for CCDC81 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with CCDC81: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC81 Gene

Orthologs for CCDC81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC81 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC81 30 31
  • 98.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC81 30 31
  • 87.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC81 30 31
  • 85.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc81 30
  • 83.13 (n)
Mouse
(Mus musculus)
Mammalia Ccdc81 30 17 31
  • 83 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC81 31
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC81 31
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 38 (a)
OneToMany
-- 31
  • 28 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
-- 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia CCDC81 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc81 30
  • 58.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToOne
Species where no ortholog for CCDC81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCDC81 Gene

ENSEMBL:
Gene Tree for CCDC81 (if available)
TreeFam:
Gene Tree for CCDC81 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC81: view image

Paralogs for CCDC81 Gene

No data available for Paralogs for CCDC81 Gene

Variants for CCDC81 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC81 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs3741005 - p.Tyr449Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC81 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC81 Gene

Variant ID Type Subtype PubMed ID
esv3627087 CNV loss 21293372

Variation tolerance for CCDC81 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC81

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC81 Gene

Disorders for CCDC81 Gene

Additional Disease Information for CCDC81

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CCDC81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC81 Gene

Publications for CCDC81 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4
  2. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan LC … Rothenberg ME (Nature genetics 2014) 3
  3. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P … Brdicka T (Molecular and cellular biology 2011) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 41

Products for CCDC81 Gene

Sources for CCDC81 Gene