Aliases for CCDC77 Gene

Aliases for CCDC77 Gene

  • Coiled-Coil Domain Containing 77 2 3 5
  • Coiled-Coil Domain-Containing Protein 77 3 4
  • MGC13183 2
  • CCDC77 5

External Ids for CCDC77 Gene

Previous GeneCards Identifiers for CCDC77 Gene

  • GC12P000498

Summaries for CCDC77 Gene

GeneCards Summary for CCDC77 Gene

CCDC77 (Coiled-Coil Domain Containing 77) is a Protein Coding gene. Diseases associated with CCDC77 include Malignant Granular Cell Myoblastoma and Fundus Dystrophy.

Additional gene information for CCDC77 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC77 Gene

Genomics for CCDC77 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC77 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC77 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC77

Top Transcription factor binding sites by QIAGEN in the CCDC77 gene promoter:
  • HNF-1
  • HNF-1A
  • Pax-2
  • Pax-2a
  • Pax-2b
  • STAT5A

Genomic Locations for CCDC77 Gene

Genomic Locations for CCDC77 Gene
53,370 bases
Plus strand
53,373 bases
Plus strand

Genomic View for CCDC77 Gene

Genes around CCDC77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC77 Gene

Proteins for CCDC77 Gene

  • Protein details for CCDC77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 77
    Protein Accession:
    Secondary Accessions:
    • B4DDE8

    Protein attributes for CCDC77 Gene

    488 amino acids
    Molecular mass:
    57486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC77 Gene


neXtProt entry for CCDC77 Gene

Post-translational modifications for CCDC77 Gene

  • Ubiquitination at Lys193, Lys440, and Lys477
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC77 Gene

Domains & Families for CCDC77 Gene

Gene Families for CCDC77 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC77 Gene


Suggested Antigen Peptide Sequences for CCDC77 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78928 (B4DDE8_HUMAN)
  • Coiled-coil domain-containing protein 77 (CCD77_HUMAN)
genes like me logo Genes that share domains with CCDC77: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC77 Gene

Function for CCDC77 Gene

Phenotypes From GWAS Catalog for CCDC77 Gene

genes like me logo Genes that share phenotypes with CCDC77: view

Animal Models for CCDC77 Gene

MGI Knock Outs for CCDC77:
  • Ccdc77 Ccdc77<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CCDC77 Gene

miRTarBase miRNAs that target CCDC77

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC77

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC77 Gene

Localization for CCDC77 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC77 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IBA,IDA 21399614
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CCDC77: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC77 Gene

Pathways & Interactions for CCDC77 Gene

PathCards logo

SuperPathways for CCDC77 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC77 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC77 Gene

Drugs & Compounds for CCDC77 Gene

No Compound Related Data Available

Transcripts for CCDC77 Gene

mRNA/cDNA for CCDC77 Gene

8 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC77

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC77 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CCDC77 Gene

GeneLoc Exon Structure for

Expression for CCDC77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC77 Gene

This gene is overexpressed in Blymphocyte (37.6) and Testis (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC77 Gene

Protein tissue co-expression partners for CCDC77 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC77

SOURCE GeneReport for Unigene cluster for CCDC77 Gene:


Evidence on tissue expression from TISSUES for CCDC77 Gene

  • Skin(4.2)
  • Nervous system(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CCDC77: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC77 Gene

Orthologs for CCDC77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC77 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC77 30 31
  • 93.88 (n)
(Canis familiaris)
Mammalia CCDC77 30 31
  • 88.46 (n)
(Mus musculus)
Mammalia Ccdc77 30 17 31
  • 82.41 (n)
(Rattus norvegicus)
Mammalia Ccdc77 30
  • 82.37 (n)
(Bos Taurus)
Mammalia CCDC77 30 31
  • 81.01 (n)
(Monodelphis domestica)
Mammalia CCDC77 31
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC77 31
  • 55 (a)
(Gallus gallus)
Aves CCDC77 30 31
  • 64.75 (n)
(Anolis carolinensis)
Reptilia CCDC77 31
  • 51 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc77 30
  • 61.61 (n)
Str.11464 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7566 30
(Danio rerio)
Actinopterygii ccdc77 30 31
  • 60.89 (n)
Dr.10395 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.479 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11775 30
Species where no ortholog for CCDC77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC77 Gene

Gene Tree for CCDC77 (if available)
Gene Tree for CCDC77 (if available)
Evolutionary constrained regions (ECRs) for CCDC77: view image

Paralogs for CCDC77 Gene

No data available for Paralogs for CCDC77 Gene

Variants for CCDC77 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC77 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs4980895 - p.Ser25Arg
rs735295 - p.Met335Thr

Additional dbSNP identifiers (rs#s) for CCDC77 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC77 Gene

Variant ID Type Subtype PubMed ID
dgv2243n54 CNV loss 21841781
dgv2244n54 CNV loss 21841781
dgv2245n54 CNV loss 21841781
dgv2246n54 CNV loss 21841781
dgv738e59 CNV duplication 20981092
dgv746n106 CNV duplication 24896259
esv1001309 CNV insertion 20482838
esv1005158 CNV gain 20482838
esv1225237 CNV deletion 17803354
esv1463722 CNV deletion 17803354
esv1479845 CNV deletion 17803354
esv1623775 CNV deletion 17803354
esv2009381 CNV deletion 18987734
esv2160803 CNV deletion 18987734
esv2313112 CNV deletion 18987734
esv2403049 CNV deletion 18987734
esv2665030 CNV deletion 23128226
esv2676807 CNV deletion 23128226
esv2745349 CNV deletion 23290073
esv2745350 CNV deletion 23290073
esv2745351 CNV deletion 23290073
esv2745353 CNV deletion 23290073
esv2759875 CNV gain+loss 17122850
esv29798 CNV loss 19812545
esv3628232 CNV gain 21293372
esv3628233 CNV loss 21293372
esv3628234 CNV gain 21293372
esv3628235 CNV loss 21293372
esv3628236 CNV gain 21293372
esv3892121 CNV gain 25118596
esv988269 CNV deletion 20482838
nsv1050781 CNV loss 25217958
nsv1069630 CNV deletion 25765185
nsv442250 CNV gain 18776908
nsv509448 CNV insertion 20534489
nsv514668 CNV gain 21397061
nsv571 CNV insertion 18451855
nsv8884 CNV gain+loss 18304495
nsv975433 CNV duplication 23825009

Variation tolerance for CCDC77 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC77 Gene

Disorders for CCDC77 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCDC77 Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant granular cell myoblastoma
  • granular cell tumor, malignant
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CCDC77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC77 Gene

Publications for CCDC77 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. (PMID: 30581152) Karras P … Soengas MS (Cancer cell 2019) 3
  5. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. (PMID: 30804394) Georges A … Frappier L (Scientific reports 2019) 3

Products for CCDC77 Gene

Sources for CCDC77 Gene