Aliases for CCDC74B Gene

Aliases for CCDC74B Gene

  • Coiled-Coil Domain Containing 74B 2 3 5
  • Coiled-Coil Domain-Containing Protein 74B 3 4
  • DKFZp434E2321 2
  • CCDC74B 5

External Ids for CCDC74B Gene

Previous GeneCards Identifiers for CCDC74B Gene

  • GC02M130614
  • GC02M130896
  • GC02M123192

Summaries for CCDC74B Gene

GeneCards Summary for CCDC74B Gene

CCDC74B (Coiled-Coil Domain Containing 74B) is a Protein Coding gene. An important paralog of this gene is CCDC74A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC74B Gene

Genomics for CCDC74B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC74B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J130144 Promoter 1.5 EPDnew Ensembl CraniofacialAtlas 250.7 +0.5 533 2 ZNF341 ELF1 KLF9 SP2 SAP130 GABPB1 SIN3A ZNF146 ZBTB48 PKNOX1 CCDC74B lnc-CCDC74B-1 piR-54904-001 TUBA3E POTEF
GH02J130130 Promoter 1.1 EPDnew Ensembl 4.6 +15.4 15433 4.2 IKZF1 SAP130 THRB MLLT1 NFYC CTCF ARID4B ZNF512 MNT RNF2 POTEF MED15P9 lnc-MZT2B-1 MZT2B RAB6C-AS1 CCDC74B lnc-CCDC74B-1
GH02J130262 Enhancer 0.3 Ensembl 5.5 -117.3 -117267 1.2 ZIC2 ZNF189 CCDC74B MTND1P29 lnc-MZT2B-4 HSALNG0018784 TUBA3E IMP4
GH02J130157 Enhancer 0.9 Ensembl ENCODE 0.4 -13.0 -13046 1.6 SP1 ZNF600 ZIC2 TRIM22 EBF1 SMARCA5 PRDM10 BHLHE40 SUPT5H POLR2A HSALNG0018779 TUBA3E piR-43666 CCDC74B lnc-TUBA3E-1 MZT2B SMPD4
GH02J130160 Enhancer 0.7 Ensembl 0.4 -16.2 -16167 1 NCOR1 MNT ARNT NBN NKRF ELF1 PRDM10 HLTF MLLT1 SUPT5H TUBA3E HSALNG0018779 piR-43666 CCDC74B lnc-TUBA3E-1 MZT2B SMPD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC74B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC74B

Top Transcription factor binding sites by QIAGEN in the CCDC74B gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • E47
  • HSF1 (long)
  • NF-Y
  • NF-YA
  • NF-YB
  • Tal-1

Genomic Locations for CCDC74B Gene

Latest Assembly
5,852 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
5,826 bases
Minus strand

(GRCh37/hg19 by Ensembl)
5,848 bases
Minus strand

Genomic View for CCDC74B Gene

Genes around CCDC74B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC74B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC74B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC74B Gene

Proteins for CCDC74B Gene

  • Protein details for CCDC74B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 74B
    Protein Accession:
    Secondary Accessions:
    • Q6NW18

    Protein attributes for CCDC74B Gene

    380 amino acids
    Molecular mass:
    41826 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC74B Gene


neXtProt entry for CCDC74B Gene

Post-translational modifications for CCDC74B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC74B Gene

Domains & Families for CCDC74B Gene

Gene Families for CCDC74B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC74B Gene

Suggested Antigen Peptide Sequences for CCDC74B Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 74B (CC74B_HUMAN)
genes like me logo Genes that share domains with CCDC74B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC74B Gene

Function for CCDC74B Gene

Gene Ontology (GO) - Molecular Function for CCDC74B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with CCDC74B: view
genes like me logo Genes that share phenotypes with CCDC74B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC74B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC74B Gene

Localization for CCDC74B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC74B gene
Compartment Confidence
nucleus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC74B Gene

Pathways & Interactions for CCDC74B Gene

PathCards logo

SuperPathways for CCDC74B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC74B Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC74B Gene

Drugs & Compounds for CCDC74B Gene

No Compound Related Data Available

Transcripts for CCDC74B Gene

mRNA/cDNA for CCDC74B Gene

7 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC74B

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC74B Gene

No ASD Table

Relevant External Links for CCDC74B Gene

GeneLoc Exon Structure for

Expression for CCDC74B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC74B Gene

mRNA differential expression in normal tissues according to GTEx for CCDC74B Gene

This gene is overexpressed in Testis (x10.5) and Pituitary (x6.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC74B

SOURCE GeneReport for Unigene cluster for CCDC74B Gene:

genes like me logo Genes that share expression patterns with CCDC74B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC74B Gene

Orthologs for CCDC74B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC74B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 30
  • 98 (a)
(Bos Taurus)
Mammalia -- 30
  • 59 (a)
(Mus musculus)
Mammalia Ccdc74a 30
  • 58 (a)
(Canis familiaris)
Mammalia -- 30
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 43 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 29 (a)
(Danio rerio)
Actinopterygii CCDC74B 30
  • 31 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 23 (a)
Species where no ortholog for CCDC74B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC74B Gene

Gene Tree for CCDC74B (if available)
Gene Tree for CCDC74B (if available)
Alliance of Genome Resources:
Additional Orthologs for CCDC74B

Paralogs for CCDC74B Gene

Paralogs for CCDC74B Gene

(4) SIMAP similar genes for CCDC74B Gene using alignment to 8 proteins:

  • C9JC78_HUMAN
  • E9PG54_HUMAN
  • F8WB40_HUMAN
  • H7C1C8_HUMAN Pseudogenes for CCDC74B Gene

genes like me logo Genes that share paralogs with CCDC74B: view

Variants for CCDC74B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC74B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs184349150 -- p.Thr169Met
rs3177472 -- p.Arg346His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC74B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC74B Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4072n100 CNV loss 25217958
dgv4073n100 CNV gain 25217958
esv2751826 CNV gain 17911159
esv2759092 CNV gain+loss 17122850
esv2760631 CNV gain+loss 21179565
esv2763387 CNV loss 21179565
esv3584065 CNV loss 25503493
esv3584069 CNV loss 25503493
esv3893326 CNV gain 25118596
nsv1001337 CNV loss 25217958
nsv1004301 CNV loss 25217958
nsv1008911 CNV gain 25217958
nsv1011360 CNV loss 25217958
nsv428403 CNV loss 18775914
nsv459274 CNV loss 19166990
nsv520559 CNV gain+loss 19592680
nsv583046 CNV loss 21841781
nsv583113 CNV gain 21841781
nsv7327 OTHER inversion 18451855
nsv821629 CNV loss 15273396
nsv834375 CNV loss 17160897
nsv953162 CNV deletion 24416366
nsv961882 CNV duplication 23825009
nsv998333 CNV gain+loss 25217958

Variation tolerance for CCDC74B Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC74B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC74B Gene

Disorders for CCDC74B Gene

Additional Disease Information for CCDC74B

No disorders were found for CCDC74B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC74B Gene

Publications for CCDC74B Gene

  1. CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment. (PMID: 31521166) Zhou H … Teng J (BMC biology 2019) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for CCDC74B Gene

Sources for CCDC74B Gene