Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC74A Gene

Aliases for CCDC74A Gene

  • Coiled-Coil Domain Containing 74A 2 3 5

External Ids for CCDC74A Gene

Previous GeneCards Identifiers for CCDC74A Gene

  • GC02P132001
  • GC02P132285
  • GC02P124278
  • GC02P131527
  • GC02P131530
  • GC02P131553
  • GC02P131565
  • GC02P131603
  • GC02P131641

Summaries for CCDC74A Gene

GeneCards Summary for CCDC74A Gene

CCDC74A (Coiled-Coil Domain Containing 74A) is a Protein Coding gene. An important paralog of this gene is CCDC74B.

Additional gene information for CCDC74A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC74A Gene

Genomics for CCDC74A Gene

GeneHancer (GH) Regulatory Elements for CCDC74A Gene

Promoters and enhancers for CCDC74A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I131527 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.4 +5.7 5660 1.4 HDGF HDAC1 PKNOX1 SIN3A BMI1 ZNF2 ZBTB40 ZNF335 EGR1 ATF7 PIR48903 CCDC74A LOC150776 MZT2A PIR38321 GC02P131710
GH02I132264 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +746.9 746912 9.7 HDGF PKNOX1 SMAD1 ARNT ZFP64 NEUROD1 SIN3A YBX1 ZBTB7B YY1 LOC105373622 LOC150776 ENSG00000272769 ZNF806 FAM201B ENSG00000213222 CCDC74A C2orf27A GC02P132278
GH02I130823 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.2 -698.1 -698054 1.9 HDGF BMI1 BATF IRF4 ZSCAN5C ZNF207 ZNF143 ATF7 ETV6 FOS GPR148 ARHGEF4 MZT2B CCDC74A CYCSP8 GC02P130572
GH02I131444 Enhancer 0.2 Ensembl 6.8 -77.8 -77840 0.4 PIR48715 NOC2LP2 LOC150776 MZT2A CCDC74A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC74A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC74A gene promoter:

Genomic Locations for CCDC74A Gene

Genomic Locations for CCDC74A Gene
chr2:131,522,641-131,533,670
(GRCh38/hg38)
Size:
11,030 bases
Orientation:
Plus strand
chr2:132,285,248-132,291,239
(GRCh37/hg19)

Genomic View for CCDC74A Gene

Genes around CCDC74A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC74A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC74A Gene

Proteins for CCDC74A Gene

  • Protein details for CCDC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ1-CC74A_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 74A
    Protein Accession:
    Q96AQ1
    Secondary Accessions:
    • Q6P4I5

    Protein attributes for CCDC74A Gene

    Size:
    378 amino acids
    Molecular mass:
    41605 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC74A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC74A Gene

Post-translational modifications for CCDC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC74A Gene

Domains & Families for CCDC74A Gene

Gene Families for CCDC74A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC74A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC74A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC74A: view

No data available for UniProtKB/Swiss-Prot for CCDC74A Gene

Function for CCDC74A Gene

genes like me logo Genes that share phenotypes with CCDC74A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC74A Gene

Localization for CCDC74A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC74A gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC74A Gene

Pathways & Interactions for CCDC74A Gene

SuperPathways for CCDC74A Gene

No Data Available

Interacting Proteins for CCDC74A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295171%0d%0a9606.ENSP00000355058%0d%0a9606.ENSP00000360181%0d%0a
Selected Interacting proteins: Q96AQ1-CC74A_HUMAN ENSP00000295171 for CCDC74A Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for CCDC74A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC74A Gene

Drugs & Compounds for CCDC74A Gene

No Compound Related Data Available

Transcripts for CCDC74A Gene

Unigene Clusters for CCDC74A Gene

Coiled-coil domain containing 74A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC74A Gene

No ASD Table

Relevant External Links for CCDC74A Gene

GeneLoc Exon Structure for
CCDC74A
ECgene alternative splicing isoforms for
CCDC74A

Expression for CCDC74A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC74A Gene

mRNA differential expression in normal tissues according to GTEx for CCDC74A Gene

This gene is overexpressed in Testis (x6.8) and Pituitary (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of CCDC74A Gene:

CCDC74A

SOURCE GeneReport for Unigene cluster for CCDC74A Gene:

Hs.351461
genes like me logo Genes that share expression patterns with CCDC74A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC74A Gene

Orthologs for CCDC74A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC74A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc74a 34
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 29 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CCDC74B 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for CCDC74A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC74A Gene

ENSEMBL:
Gene Tree for CCDC74A (if available)
TreeFam:
Gene Tree for CCDC74A (if available)

Paralogs for CCDC74A Gene

Paralogs for CCDC74A Gene

(4) SIMAP similar genes for CCDC74A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CCDC74A Gene

genes like me logo Genes that share paralogs with CCDC74A: view

Variants for CCDC74A Gene

Sequence variations from dbSNP and Humsavar for CCDC74A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000093579 -- 131,528,753(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000327009 -- 131,523,228(+) T/C genic_upstream_transcript_variant, intron_variant
rs1001467411 -- 131,523,834(+) A/G genic_upstream_transcript_variant, intron_variant
rs1001527348 -- 131,529,327(+) A/C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001641853 -- 131,529,136(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC74A Gene

Variant ID Type Subtype PubMed ID
dgv4077n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv4080n100 CNV gain 25217958
dgv476n27 CNV loss 19166990
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv34704 CNV gain 17911159
esv3592485 CNV gain 21293372
esv3893359 CNV gain+loss 25118596
nsv1002963 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv10185 CNV gain+loss 18304495
nsv2926 CNV insertion 18451855
nsv428404 CNV loss 18775914
nsv459396 CNV gain 19166990
nsv470486 CNV loss 18288195
nsv483103 CNV gain+loss 15286789
nsv524021 CNV loss 19592680
nsv583140 CNV gain 21841781
nsv583143 CNV gain+loss 21841781
nsv7327 OTHER inversion 18451855
nsv834376 CNV gain 17160897
nsv979124 CNV duplication 23825009
nsv997248 CNV loss 25217958

Variation tolerance for CCDC74A Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC74A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC74A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC74A Gene

Disorders for CCDC74A Gene

Additional Disease Information for CCDC74A

No disorders were found for CCDC74A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC74A Gene

Publications for CCDC74A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58

Products for CCDC74A Gene

Sources for CCDC74A Gene

Content
Loading form....