Aliases for CCDC74A Gene

Aliases for CCDC74A Gene

  • Coiled-Coil Domain Containing 74A 2 3 5
  • Coiled-Coil Domain-Containing Protein 74A 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • FLJ40345 2
  • CCDC74A 5

External Ids for CCDC74A Gene

Previous GeneCards Identifiers for CCDC74A Gene

  • GC02P132001
  • GC02P132285
  • GC02P124278
  • GC02P131527
  • GC02P131818
  • GC02P131894
  • GC02P131838
  • GC02P132468
  • GC02P131530
  • GC02P131553
  • GC02P131565
  • GC02P131603
  • GC02P131641
  • GC02P131672
  • GC02P131721
  • GC02P131767
  • GC02P132754
  • GC02P133058

Summaries for CCDC74A Gene

GeneCards Summary for CCDC74A Gene

CCDC74A (Coiled-Coil Domain Containing 74A) is a Protein Coding gene. An important paralog of this gene is CCDC74B.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC74A Gene

Genomics for CCDC74A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC74A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC74A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC74A

Top Transcription factor binding sites by QIAGEN in the CCDC74A gene promoter:
  • AML1a
  • CUTL1
  • E47
  • GATA-2
  • HEN1
  • HSF1 (long)
  • HSF1short
  • MRF-2
  • NRSF form 1
  • Tal-1

Genomic Locations for CCDC74A Gene

Latest Assembly
11,046 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
5,779 bases
Plus strand

(GRCh37/hg19 by Ensembl)
5,992 bases
Plus strand

Genomic View for CCDC74A Gene

Genes around CCDC74A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC74A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC74A Gene

Proteins for CCDC74A Gene

  • Protein details for CCDC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 74A
    Protein Accession:
    Secondary Accessions:
    • Q6P4I5

    Protein attributes for CCDC74A Gene

    378 amino acids
    Molecular mass:
    41605 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC74A Gene


neXtProt entry for CCDC74A Gene

Post-translational modifications for CCDC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC74A Gene

Domains & Families for CCDC74A Gene

Gene Families for CCDC74A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC74A Gene

Suggested Antigen Peptide Sequences for CCDC74A Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 74A (CC74A_HUMAN)
  • CCDC74A protein (Q4G142_HUMAN)
genes like me logo Genes that share domains with CCDC74A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC74A Gene

Function for CCDC74A Gene

Phenotypes From GWAS Catalog for CCDC74A Gene

Gene Ontology (GO) - Molecular Function for CCDC74A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with CCDC74A: view
genes like me logo Genes that share phenotypes with CCDC74A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC74A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC74A Gene

Localization for CCDC74A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC74A gene
Compartment Confidence
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC74A Gene

Pathways & Interactions for CCDC74A Gene

PathCards logo

SuperPathways for CCDC74A Gene

No Data Available

Interacting Proteins for CCDC74A Gene

Gene Ontology (GO) - Biological Process for CCDC74A Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC74A Gene

Drugs & Compounds for CCDC74A Gene

No Compound Related Data Available

Transcripts for CCDC74A Gene

mRNA/cDNA for CCDC74A Gene

10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC74A

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC74A Gene

No ASD Table

Relevant External Links for CCDC74A Gene

GeneLoc Exon Structure for

Expression for CCDC74A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC74A Gene

mRNA differential expression in normal tissues according to GTEx for CCDC74A Gene

This gene is overexpressed in Testis (x6.8) and Pituitary (x5.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC74A

SOURCE GeneReport for Unigene cluster for CCDC74A Gene:

genes like me logo Genes that share expression patterns with CCDC74A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC74A Gene

Orthologs for CCDC74A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC74A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 30
  • 97 (a)
(Bos Taurus)
Mammalia -- 30
  • 59 (a)
(Mus musculus)
Mammalia Ccdc74a 30
  • 58 (a)
(Canis familiaris)
Mammalia -- 30
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 43 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 29 (a)
(Danio rerio)
Actinopterygii CCDC74B 30
  • 31 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 23 (a)
Species where no ortholog for CCDC74A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC74A Gene

Gene Tree for CCDC74A (if available)
Gene Tree for CCDC74A (if available)
Evolutionary constrained regions (ECRs) for CCDC74A: view image
Alliance of Genome Resources:
Additional Orthologs for CCDC74A

Paralogs for CCDC74A Gene

Paralogs for CCDC74A Gene

(4) SIMAP similar genes for CCDC74A Gene using alignment to 5 proteins:

  • Q4G142_HUMAN Pseudogenes for CCDC74A Gene

genes like me logo Genes that share paralogs with CCDC74A: view

Variants for CCDC74A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC74A Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs13660 -- p.Gly302Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC74A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC74A Gene

Variant ID Type Subtype PubMed ID
dgv4077n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv4080n100 CNV gain 25217958
dgv476n27 CNV loss 19166990
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv34704 CNV gain 17911159
esv3592485 CNV gain 21293372
esv3893359 CNV gain+loss 25118596
nsv1002963 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv10185 CNV gain+loss 18304495
nsv2926 CNV insertion 18451855
nsv428404 CNV loss 18775914
nsv459396 CNV gain 19166990
nsv470486 CNV loss 18288195
nsv483103 CNV gain+loss 15286789
nsv524021 CNV loss 19592680
nsv583140 CNV gain 21841781
nsv583143 CNV gain+loss 21841781
nsv7327 OTHER inversion 18451855
nsv834376 CNV gain 17160897
nsv979124 CNV duplication 23825009
nsv997248 CNV loss 25217958

Variation tolerance for CCDC74A Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC74A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC74A Gene

Disorders for CCDC74A Gene

Additional Disease Information for CCDC74A

No disorders were found for CCDC74A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC74A Gene

Publications for CCDC74A Gene

  1. CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment. (PMID: 31521166) Zhou H … Teng J (BMC biology 2019) 2 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3

Products for CCDC74A Gene

Sources for CCDC74A Gene