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Aliases for CCDC73 Gene

Aliases for CCDC73 Gene

  • Coiled-Coil Domain Containing 73 2 3 5
  • Sarcoma Antigen NY-SAR-79 3 4
  • Coiled-Coil Domain-Containing Protein 73 3
  • NY-SAR-79 3

External Ids for CCDC73 Gene

Previous GeneCards Identifiers for CCDC73 Gene

  • GC11M032582
  • GC11M032318

Summaries for CCDC73 Gene

GeneCards Summary for CCDC73 Gene

CCDC73 (Coiled-Coil Domain Containing 73) is a Protein Coding gene. Diseases associated with CCDC73 include Cryptorchidism, Unilateral Or Bilateral.

Additional gene information for CCDC73 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC73 Gene

Genomics for CCDC73 Gene

GeneHancer (GH) Regulatory Elements for CCDC73 Gene

Promoters and enhancers for CCDC73 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I032792 Enhancer 0.8 Ensembl ENCODE 550.8 +1.6 1557 0.6 CTCF ZNF654 TRIM22 REST ELF1 RAD21 IKZF1 ZNF143 SMC3 CCDC73 EIF3M HNRNPA3P9 RPL34P2
GH11I032794 Promoter 0.7 EPDnew 550.8 +0.0 13 0.1 L3MBTL2 GABPB1 CCDC73 GC11M032795 RPL34P2
GH11I032890 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -98.8 -98797 4.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B POLR2B CBX5 QSER1 HNRNPA3P9 CSTF3 CCDC73 PIR46589
GH11I032706 Enhancer 1.1 FANTOM5 ENCODE 11.6 +87.3 87316 1.3 FOXA2 BATF ZNF366 SCRT2 ATF7 RCOR1 FOS IKZF2 ZNF362 JUNB CCDC73 EIF3M HNRNPA3P9 ENSG00000244535
GH11I032333 Enhancer 0.7 Ensembl ENCODE 10 +461.0 460951 1.1 CTCF RXRA MAX HNF4A RAD21 EZH2 WT1 WT1-AS CCDC73 THEM7P PIR50067
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC73 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC73 gene promoter:

Genomic Locations for CCDC73 Gene

Genomic Locations for CCDC73 Gene
192,579 bases
Minus strand

Genomic View for CCDC73 Gene

Genes around CCDC73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC73 Gene

Proteins for CCDC73 Gene

  • Protein details for CCDC73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 73
    Protein Accession:
    Secondary Accessions:
    • Q6P5Q7
    • Q6ZMW0
    • Q86WE7

    Protein attributes for CCDC73 Gene

    1079 amino acids
    Molecular mass:
    124154 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH62749.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO65175.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAC87304.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18615.1; Type=Frameshift; Positions=448; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC73 Gene


neXtProt entry for CCDC73 Gene

Post-translational modifications for CCDC73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC73 Gene

No data available for DME Specific Peptides for CCDC73 Gene

Domains & Families for CCDC73 Gene

Gene Families for CCDC73 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC73 Gene


Suggested Antigen Peptide Sequences for CCDC73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC73: view

No data available for UniProtKB/Swiss-Prot for CCDC73 Gene

Function for CCDC73 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC73 Gene

Localization for CCDC73 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC73 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC73 Gene

Pathways & Interactions for CCDC73 Gene

SuperPathways for CCDC73 Gene

No Data Available

Interacting Proteins for CCDC73 Gene

Gene Ontology (GO) - Biological Process for CCDC73 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC73 Gene

Drugs & Compounds for CCDC73 Gene

No Compound Related Data Available

Transcripts for CCDC73 Gene

mRNA/cDNA for CCDC73 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC73 Gene

Coiled-coil domain containing 73:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC73 Gene

No ASD Table

Relevant External Links for CCDC73 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC73 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC73 Gene

This gene is overexpressed in Testis (x22.5).

Protein differential expression in normal tissues from HIPED for CCDC73 Gene

This gene is overexpressed in Liver (38.3), Bone (11.7), and Fetal ovary (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC73 Gene

Protein tissue co-expression partners for CCDC73 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC73 Gene:


SOURCE GeneReport for Unigene cluster for CCDC73 Gene:

genes like me logo Genes that share expression patterns with CCDC73: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC73 Gene

Orthologs for CCDC73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC73 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC73 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia CCDC73 33 34
  • 87.1 (n)
(Bos Taurus)
Mammalia CCDC73 33 34
  • 86.64 (n)
(Mus musculus)
Mammalia Ccdc73 33 16 34
  • 77.41 (n)
(Rattus norvegicus)
Mammalia Ccdc73 33
  • 76.65 (n)
(Ornithorhynchus anatinus)
Mammalia CCDC73 34
  • 50 (a)
(Monodelphis domestica)
Mammalia CCDC73 34
  • 47 (a)
(Gallus gallus)
Aves CCDC73 34
  • 39 (a)
(Anolis carolinensis)
Reptilia CCDC73 34
  • 64 (a)
(Danio rerio)
Actinopterygii ccdc73 34
  • 31 (a)
Species where no ortholog for CCDC73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC73 Gene

Gene Tree for CCDC73 (if available)
Gene Tree for CCDC73 (if available)

Paralogs for CCDC73 Gene

No data available for Paralogs for CCDC73 Gene

Variants for CCDC73 Gene

Sequence variations from dbSNP and Humsavar for CCDC73 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010601 -- 32,699,547(-) G/A intron_variant
rs1000016157 -- 32,754,666(-) T/A intron_variant
rs1000017024 -- 32,737,966(-) C/T intron_variant
rs1000075575 -- 32,732,667(-) T/G intron_variant
rs1000075868 -- 32,614,305(-) T/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC73 Gene

Variant ID Type Subtype PubMed ID
esv1483356 CNV deletion 17803354
esv2646311 CNV deletion 19546169
esv2744317 CNV deletion 23290073
esv2744318 CNV deletion 23290073
esv2759815 CNV gain 17122850
esv3305860 CNV mobile element insertion 20981092
esv3351163 CNV duplication 20981092
esv3414559 CNV insertion 20981092
esv34742 CNV gain 17911159
nsv1043616 CNV loss 25217958
nsv1159852 CNV deletion 26073780
nsv477740 CNV novel sequence insertion 20440878
nsv832109 CNV gain 17160897
nsv957216 CNV deletion 24416366
nsv971998 CNV duplication 23825009

Variation tolerance for CCDC73 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC73 Gene

Disorders for CCDC73 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC73 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC73

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCDC73: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC73 Gene

Publications for CCDC73 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 44 58
  3. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee SY … Scanlan MJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner BL … Wichterle H (PloS one 2015) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for CCDC73 Gene

Sources for CCDC73 Gene

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