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Aliases for CCDC71L Gene

Aliases for CCDC71L Gene

  • Coiled-Coil Domain Containing 71 Like 2 3 5
  • C7orf74 3 4
  • Coiled-Coil Domain-Containing Protein 71L 3
  • Chromosome 7 Open Reading Frame 74 2

External Ids for CCDC71L Gene

Previous HGNC Symbols for CCDC71L Gene

  • C7orf74

Previous GeneCards Identifiers for CCDC71L Gene

  • GC07M106298

Summaries for CCDC71L Gene

GeneCards Summary for CCDC71L Gene

CCDC71L (Coiled-Coil Domain Containing 71 Like) is a Protein Coding gene.

Additional gene information for CCDC71L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC71L Gene

Genomics for CCDC71L Gene

GeneHancer (GH) Regulatory Elements for CCDC71L Gene

Promoters and enhancers for CCDC71L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I106657 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.6 1587 5 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 ZBTB7B YY1 POLR2B ZNF766 CCDC71L ATXN7L1 LOC105375440 ENSG00000243797
GH07I106716 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14 -56.9 -56859 3.5 PKNOX1 SMAD1 ARNT IRF4 E2F8 FOS JUNB REST ZNF592 SREBF1 CCDC71L HBP1 NAMPT PIK3CG ENSG00000243797
GH07I106772 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -113.4 -113363 4.6 HDGF PKNOX1 SMAD1 ARNT YY1 POLR2B ZNF766 E2F8 FOS ZNF592 LINC02577 ATXN7L1 CBLL1 ENSG00000272072 CCDC71L ENSG00000267052 PIK3CG COG5 ENSG00000243797
GH07I106567 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +92.1 92126 2.7 HDGF FOXA2 PKNOX1 SMAD1 ARNT NEUROD1 FEZF1 ZNF2 YY1 POLR2B ENSG00000272072 ATXN7L1 CCDC71L COG5 NAMPT ENSG00000267052 ENSG00000243797 LARP1BP2
GH07I106552 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +108.5 108487 1.3 PKNOX1 RB1 BMI1 YBX1 BATF KLF5 IRF4 YY1 ZNF766 ZNF207 CCDC71L NAMPT PIK3CG ENSG00000267052 ENSG00000243797 LARP1BP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC71L on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCDC71L Gene

Genomic Locations for CCDC71L Gene
chr7:106,656,765-106,661,188
(GRCh38/hg38)
Size:
4,424 bases
Orientation:
Minus strand
chr7:106,297,211-106,301,634
(GRCh37/hg19)

Genomic View for CCDC71L Gene

Genes around CCDC71L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC71L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC71L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC71L Gene

Proteins for CCDC71L Gene

  • Protein details for CCDC71L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Z2-CC71L_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 71L
    Protein Accession:
    Q8N9Z2
    Secondary Accessions:
    • Q7Z756

    Protein attributes for CCDC71L Gene

    Size:
    235 amino acids
    Molecular mass:
    26261 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13906.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC71L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC71L Gene

Post-translational modifications for CCDC71L Gene

  • Ubiquitination at Lys54, posLast=6161, and posLast=9696
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC71L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC71L Gene

Domains & Families for CCDC71L Gene

Gene Families for CCDC71L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC71L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC71L: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC71L Gene

Function for CCDC71L Gene

Phenotypes From GWAS Catalog for CCDC71L Gene

Phenotypes for CCDC71L Gene

genes like me logo Genes that share phenotypes with CCDC71L: view

Animal Model Products

CRISPR Products

miRNA for CCDC71L Gene

miRTarBase miRNAs that target CCDC71L

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC71L Gene

Localization for CCDC71L Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC71L Gene

Pathways & Interactions for CCDC71L Gene

SuperPathways for CCDC71L Gene

No Data Available

Interacting Proteins for CCDC71L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000430897%0d%0a9606.ENSP00000336687%0d%0a
Selected Interacting proteins: ENSP00000430897 Q8N9Z2-CC71L_HUMAN for CCDC71L Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC71L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process ISS --
GO:0045600 positive regulation of fat cell differentiation ISS --
genes like me logo Genes that share ontologies with CCDC71L: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC71L Gene

Drugs & Compounds for CCDC71L Gene

No Compound Related Data Available

Transcripts for CCDC71L Gene

mRNA/cDNA for CCDC71L Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(169) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC71L Gene

Coiled-coil domain containing 71-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC71L Gene

No ASD Table

Relevant External Links for CCDC71L Gene

GeneLoc Exon Structure for
CCDC71L
ECgene alternative splicing isoforms for
CCDC71L

Expression for CCDC71L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC71L Gene

Protein differential expression in normal tissues from HIPED for CCDC71L Gene

This gene is overexpressed in Rectum (22.6), Spleen (13.3), Oral epithelium (10.8), and Stomach (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC71L Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC71L Gene:

CCDC71L

SOURCE GeneReport for Unigene cluster for CCDC71L Gene:

Hs.29692
genes like me logo Genes that share expression patterns with CCDC71L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC71L Gene

Orthologs for CCDC71L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC71L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC71L 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia CCDC71L 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc71l 33
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Ccdc71l 33 16 34
  • 80.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC71L 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC71L 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC71L 34
  • 48 (a)
OneToOne
Species where no ortholog for CCDC71L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC71L Gene

ENSEMBL:
Gene Tree for CCDC71L (if available)
TreeFam:
Gene Tree for CCDC71L (if available)

Paralogs for CCDC71L Gene

No data available for Paralogs for CCDC71L Gene

Variants for CCDC71L Gene

Sequence variations from dbSNP and Humsavar for CCDC71L Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs869025233 uncertain-significance, Ductal breast carcinoma 106,660,419(-) T/G coding_sequence_variant, missense_variant
rs1000667404 -- 106,657,230(-) T/C 3_prime_UTR_variant
rs1000674102 -- 106,656,898(-) A/C 3_prime_UTR_variant
rs1000879162 -- 106,660,411(-) C/T coding_sequence_variant, synonymous_variant
rs1001514776 -- 106,656,506(-) T/A downstream_transcript_variant

Variation tolerance for CCDC71L Gene

Gene Damage Index Score: 0.12; 2.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC71L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC71L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC71L Gene

Disorders for CCDC71L Gene

Additional Disease Information for CCDC71L

No disorders were found for CCDC71L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC71L Gene

Publications for CCDC71L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58

Products for CCDC71L Gene

Sources for CCDC71L Gene

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