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Aliases for CCDC71 Gene

Aliases for CCDC71 Gene

  • Coiled-Coil Domain Containing 71 2 3 5
  • Coiled-Coil Domain-Containing Protein 71 3
  • 2600016J21Rik 3

External Ids for CCDC71 Gene

Previous GeneCards Identifiers for CCDC71 Gene

  • GC03M049174

Summaries for CCDC71 Gene

GeneCards Summary for CCDC71 Gene

CCDC71 (Coiled-Coil Domain Containing 71) is a Protein Coding gene.

Additional gene information for CCDC71 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC71 Gene

Genomics for CCDC71 Gene

GeneHancer (GH) Regulatory Elements for CCDC71 Gene

Promoters and enhancers for CCDC71 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049164 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.8 +0.3 318 2.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 E2F8 CCDC71 PIR60212 WDR6 QRICH1 USP19 ZNF589 NME6 MRPS18AP1 QARS ATRIP
GH03J049409 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 22.2 -247.5 -247455 8.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 AMT TCTA RHOA CCDC71 WDR6 SEMA3F-AS1 QRICH1 INKA1 RBM5 RNA5SP130
GH03J049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.5 +146.1 146091 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 GC03M049024 MIR191 NDUFAF3 MIR425 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1
GH03J048239 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.2 +925.4 925428 2.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF589 GC03M048234 QRICH1 PTPN23 NME6 ATRIP IP6K2 CCDC71 USP19 MRPS18AP1
GH03J048186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.2 +978.4 978437 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 FOS CDC25A ZNF589 QRICH1 ATRIP USP19 TMEM89 CCDC71 PTPN23 NME6 MRPS18AP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC71 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC71 gene promoter:

Genomic Locations for CCDC71 Gene

Genomic Locations for CCDC71 Gene
chr3:49,162,535-49,166,352
(GRCh38/hg38)
Size:
3,818 bases
Orientation:
Minus strand
chr3:49,199,968-49,203,785
(GRCh37/hg19)

Genomic View for CCDC71 Gene

Genes around CCDC71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC71 Gene

Proteins for CCDC71 Gene

  • Protein details for CCDC71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV32-CCD71_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 71
    Protein Accession:
    Q8IV32
    Secondary Accessions:
    • Q6IPE2
    • Q9H8H4
    • Q9H9F1

    Protein attributes for CCDC71 Gene

    Size:
    467 amino acids
    Molecular mass:
    49648 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14642.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CCDC71 Gene

Post-translational modifications for CCDC71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC71 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC71 Gene

Domains & Families for CCDC71 Gene

Gene Families for CCDC71 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC71: view

No data available for UniProtKB/Swiss-Prot for CCDC71 Gene

Function for CCDC71 Gene

Phenotypes From GWAS Catalog for CCDC71 Gene

genes like me logo Genes that share phenotypes with CCDC71: view

Animal Model Products

miRNA for CCDC71 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC71 Gene

Localization for CCDC71 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC71 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC71 Gene

Pathways & Interactions for CCDC71 Gene

SuperPathways for CCDC71 Gene

No Data Available

Interacting Proteins for CCDC71 Gene

Gene Ontology (GO) - Biological Process for CCDC71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC71 Gene

Drugs & Compounds for CCDC71 Gene

No Compound Related Data Available

Transcripts for CCDC71 Gene

mRNA/cDNA for CCDC71 Gene

(46) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC71 Gene

Coiled-coil domain containing 71:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC71 Gene

No ASD Table

Relevant External Links for CCDC71 Gene

GeneLoc Exon Structure for
CCDC71
ECgene alternative splicing isoforms for
CCDC71

Expression for CCDC71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC71 Gene

Protein differential expression in normal tissues from HIPED for CCDC71 Gene

This gene is overexpressed in Saliva (27.1), Placenta (15.7), Esophagus (11.3), and Frontal cortex (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC71 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC71 Gene:

CCDC71

SOURCE GeneReport for Unigene cluster for CCDC71 Gene:

Hs.211472

Evidence on tissue expression from TISSUES for CCDC71 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCDC71: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC71 Gene

Orthologs for CCDC71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC71 34 33
  • 96.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC71 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC71 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc71 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC71 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC71 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC71 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC71 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCDC71 34
  • 28 (a)
OneToOne
Species where no ortholog for CCDC71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC71 Gene

ENSEMBL:
Gene Tree for CCDC71 (if available)
TreeFam:
Gene Tree for CCDC71 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC71: view image

Paralogs for CCDC71 Gene

No data available for Paralogs for CCDC71 Gene

Variants for CCDC71 Gene

Sequence variations from dbSNP and Humsavar for CCDC71 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000452748 -- 49,162,436(-) G/A downstream_transcript_variant
rs1001717629 -- 49,164,507(-) C/T intron_variant
rs1002388302 -- 49,163,572(-) G/A coding_sequence_variant, missense_variant
rs1002399046 -- 49,164,797(-) A/G intron_variant
rs1003061879 -- 49,166,463(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC71 Gene

Variant ID Type Subtype PubMed ID
nsv834686 CNV loss 17160897

Variation tolerance for CCDC71 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC71 Gene

Disorders for CCDC71 Gene

Additional Disease Information for CCDC71

No disorders were found for CCDC71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC71 Gene

Publications for CCDC71 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CCDC71 Gene

Sources for CCDC71 Gene

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