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Aliases for CCDC70 Gene

Aliases for CCDC70 Gene

  • Coiled-Coil Domain Containing 70 2 3 5

External Ids for CCDC70 Gene

Previous GeneCards Identifiers for CCDC70 Gene

  • GC13P051335
  • GC13P052436
  • GC13P033224

Summaries for CCDC70 Gene

GeneCards Summary for CCDC70 Gene

CCDC70 (Coiled-Coil Domain Containing 70) is a Protein Coding gene.

Gene Wiki entry for CCDC70 Gene

Additional gene information for CCDC70 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC70 Gene

Genomics for CCDC70 Gene

GeneHancer (GH) Regulatory Elements for CCDC70 Gene

Promoters and enhancers for CCDC70 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I051861 Promoter 0.9 EPDnew 550.8 0.0 -31 0.1 SMARCE1 JUN DPF2 ZEB2 FOSL1 SMARCA4 VEZF1 NR2C1 KDM1A FOS CCDC70 TMEM272
GH13I051820 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11 -37.6 -37574 7.4 ZFP64 MAX CEBPG POLR2A ZSCAN29 RCOR1 MAFK SRF HLF CEBPB DHRS12 ENSG00000231856 CCDC70 NEK5 WDFY2 TMEM272
GH13I051995 Enhancer 1.2 Ensembl ENCODE 10.2 +135.8 135765 5 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF48 YY1 TCF12 GLIS2 RXRA ATP7B NEK3 NEK5 TPTE2P2 UTP14C CCDC70 DHRS12 ENSG00000231856 FABP5P2
GH13I051832 Enhancer 1 Ensembl ENCODE dbSUPER 11.2 -29.4 -29367 0.4 BCOR CTCF ZNF654 TRIM22 ZMYM3 EBF1 RAD21 ZFHX2 POLR2A NBN ENSG00000231856 DHRS12 CCDC70 TMEM272
GH13I052186 Enhancer 1 ENCODE dbSUPER 10.5 +326.1 326056 2.3 HDAC1 PKNOX1 ARID4B BMI1 TCF12 ZNF766 ATF7 CREM USF2 REST NEK3 NEK5 CCDC70 ALG11 VPS36 ATP7B DHRS12 ENSG00000231856 ENSG00000244471 MRPS31P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC70 gene promoter:

Genomic Locations for CCDC70 Gene

Genomic Locations for CCDC70 Gene
chr13:51,861,981-51,866,236
(GRCh38/hg38)
Size:
4,256 bases
Orientation:
Plus strand
chr13:52,436,117-52,440,372
(GRCh37/hg19)

Genomic View for CCDC70 Gene

Genes around CCDC70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC70 Gene

Proteins for CCDC70 Gene

  • Protein details for CCDC70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSX1-CCD70_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 70
    Protein Accession:
    Q6NSX1
    Secondary Accessions:
    • Q8N7A8
    • Q9H097

    Protein attributes for CCDC70 Gene

    Size:
    233 amino acids
    Molecular mass:
    28767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC70 Gene

Post-translational modifications for CCDC70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC70 Gene

Domains & Families for CCDC70 Gene

Gene Families for CCDC70 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC70 Gene

Suggested Antigen Peptide Sequences for CCDC70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC70: view

No data available for UniProtKB/Swiss-Prot for CCDC70 Gene

Function for CCDC70 Gene

Gene Ontology (GO) - Molecular Function for CCDC70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC70: view

Phenotypes for CCDC70 Gene

genes like me logo Genes that share phenotypes with CCDC70: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC70 Gene

Localization for CCDC70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC70 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC70 gene
Compartment Confidence
plasma membrane 4
extracellular 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CCDC70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CCDC70: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC70 Gene

Pathways & Interactions for CCDC70 Gene

SuperPathways for CCDC70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC70 Gene

Drugs & Compounds for CCDC70 Gene

No Compound Related Data Available

Transcripts for CCDC70 Gene

mRNA/cDNA for CCDC70 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC70 Gene

Coiled-coil domain containing 70:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC70 Gene

No ASD Table

Relevant External Links for CCDC70 Gene

GeneLoc Exon Structure for
CCDC70
ECgene alternative splicing isoforms for
CCDC70

Expression for CCDC70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC70 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC70 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for CCDC70 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC70 Gene



Protein tissue co-expression partners for CCDC70 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC70 Gene:

CCDC70

SOURCE GeneReport for Unigene cluster for CCDC70 Gene:

Hs.120573
genes like me logo Genes that share expression patterns with CCDC70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC70 Gene

Orthologs for CCDC70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC70 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia CCDC70 33 34
  • 83.78 (n)
mouse
(Mus musculus)
Mammalia Ccdc70 33 16 34
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia CCDC70 33 34
  • 82.88 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC70 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC70 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC70 34
  • 33 (a)
OneToOne
Species where no ortholog for CCDC70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC70 Gene

ENSEMBL:
Gene Tree for CCDC70 (if available)
TreeFam:
Gene Tree for CCDC70 (if available)

Paralogs for CCDC70 Gene

No data available for Paralogs for CCDC70 Gene

Variants for CCDC70 Gene

Sequence variations from dbSNP and Humsavar for CCDC70 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000003540 -- 51,863,694(+) CACACACACACACAC/ intron_variant
rs1000960919 -- 51,864,883(+) C/T intron_variant
rs1001013140 -- 51,865,159(+) A/G intron_variant
rs1001360107 -- 51,863,878(+) G/A intron_variant
rs1002069461 -- 51,860,671(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC70 Gene

Variant ID Type Subtype PubMed ID
dgv1652n100 CNV loss 25217958
esv3892343 CNV gain 25118596

Variation tolerance for CCDC70 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC70 Gene

Disorders for CCDC70 Gene

Additional Disease Information for CCDC70

No disorders were found for CCDC70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC70 Gene

Publications for CCDC70 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58

Products for CCDC70 Gene

Sources for CCDC70 Gene

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