Aliases for CCDC69 Gene

Aliases for CCDC69 Gene

  • Coiled-Coil Domain Containing 69 2 3 5
  • Coiled-Coil Domain-Containing Protein 69 3 4
  • DKFZP434C171 2
  • FLJ13705 2
  • CCDC69 5

External Ids for CCDC69 Gene

Previous GeneCards Identifiers for CCDC69 Gene

  • GC05M150541
  • GC05M145706
  • GC05M150560

Summaries for CCDC69 Gene

GeneCards Summary for CCDC69 Gene

CCDC69 (Coiled-Coil Domain Containing 69) is a Protein Coding gene. An important paralog of this gene is MTUS2.

UniProtKB/Swiss-Prot Summary for CCDC69 Gene

  • May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC69 Gene

Genomics for CCDC69 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC69 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC69 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC69

Top Transcription factor binding sites by QIAGEN in the CCDC69 gene promoter:
  • ITF-2
  • MRF-2
  • NRSF form 1
  • NRSF form 2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for CCDC69 Gene

Latest Assembly
chr5:151,181,052-151,224,093
(GRCh38/hg38)
Size:
43,042 bases
Orientation:
Minus strand

Previous Assembly
chr5:150,560,613-150,603,653
(GRCh37/hg19 by Entrez Gene)
Size:
43,041 bases
Orientation:
Minus strand

chr5:150,560,613-150,603,706
(GRCh37/hg19 by Ensembl)
Size:
43,094 bases
Orientation:
Minus strand

Genomic View for CCDC69 Gene

Genes around CCDC69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC69 Gene

Proteins for CCDC69 Gene

  • Protein details for CCDC69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI79-CCD69_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 69
    Protein Accession:
    A6NI79
    Secondary Accessions:
    • A8K9X6

    Protein attributes for CCDC69 Gene

    Size:
    296 amino acids
    Molecular mass:
    34796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC69 Gene

Post-translational modifications for CCDC69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC69 Gene

No data available for DME Specific Peptides for CCDC69 Gene

Domains & Families for CCDC69 Gene

Gene Families for CCDC69 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC69 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC69 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 69 (CCD69_HUMAN)
  • Coiled-coil domain containing 69, isoform CRA_a (D3DQH5_HUMAN)
  • CCDC69 protein (Q7L2X4_HUMAN)
  • cDNA FLJ13705 fis, clone PLACE2000302 (Q9H8E5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NI79

UniProtKB/Swiss-Prot:

CCD69_HUMAN :
  • Belongs to the CCDC69 family.
Family:
  • Belongs to the CCDC69 family.
genes like me logo Genes that share domains with CCDC69: view

Function for CCDC69 Gene

Molecular function for CCDC69 Gene

UniProtKB/Swiss-Prot Function:
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.

Phenotypes From GWAS Catalog for CCDC69 Gene

Gene Ontology (GO) - Molecular Function for CCDC69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with CCDC69: view
genes like me logo Genes that share phenotypes with CCDC69: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC69

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC69 Gene

Localization for CCDC69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC69 Gene

Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase. {ECO:0000269 PubMed:20962590}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC69 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 colocalizes_with cytoplasm IBA 21873635
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with CCDC69: view

Pathways & Interactions for CCDC69 Gene

PathCards logo

SuperPathways for CCDC69 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051255 spindle midzone assembly IMP 20962590
genes like me logo Genes that share ontologies with CCDC69: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC69 Gene

Drugs & Compounds for CCDC69 Gene

No Compound Related Data Available

Transcripts for CCDC69 Gene

mRNA/cDNA for CCDC69 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC69

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC69 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11
SP1: - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CCDC69 Gene

GeneLoc Exon Structure for
CCDC69

Expression for CCDC69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC69 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC69 Gene

This gene is overexpressed in Plasma (28.9), Serum (17.0), and Monocytes (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC69 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC69

SOURCE GeneReport for Unigene cluster for CCDC69 Gene:

Hs.655336

mRNA Expression by UniProt/SwissProt for CCDC69 Gene:

A6NI79-CCD69_HUMAN
Tissue specificity: Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder.

Evidence on tissue expression from TISSUES for CCDC69 Gene

  • Liver(4.3)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with CCDC69: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC69 Gene

Orthologs for CCDC69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC69 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC69 30 31
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC69 30 31
  • 86.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC69 30 31
  • 85.49 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC69 31
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC69 31
  • 50 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc69 31
  • 48 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC69 30 31
  • 66.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC69 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc69 30
  • 55.76 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc69 30
  • 54.48 (n)
CABZ01005777.1 31
  • 27 (a)
OneToOne
Species where no ortholog for CCDC69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC69 Gene

ENSEMBL:
Gene Tree for CCDC69 (if available)
TreeFam:
Gene Tree for CCDC69 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC69: view image

Paralogs for CCDC69 Gene

Paralogs for CCDC69 Gene

(1) SIMAP similar genes for CCDC69 Gene using alignment to 6 proteins:

  • CCD69_HUMAN
  • D3DQH5_HUMAN
  • E5RK59_HUMAN
  • H0YB32_HUMAN
  • H0YBY5_HUMAN
  • Q7L2X4_HUMAN
genes like me logo Genes that share paralogs with CCDC69: view

Variants for CCDC69 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC69 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs248427 - p.Arg197Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC69 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC69 Gene

Variant ID Type Subtype PubMed ID
nsv1133364 CNV tandem duplication 24896259

Variation tolerance for CCDC69 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.19; 92.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC69

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC69 Gene

Disorders for CCDC69 Gene

Additional Disease Information for CCDC69

No disorders were found for CCDC69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC69 Gene

Publications for CCDC69 Gene

  1. Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly. (PMID: 20962590) Pal D … Wei Q (Cell cycle (Georgetown, Tex.) 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Overexpression of CCDC69 activates p14ARF/MDM2/p53 pathway and confers cisplatin sensitivity. (PMID: 30651135) Cui L … Wang CC (Journal of ovarian research 2019) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4

Products for CCDC69 Gene

Sources for CCDC69 Gene