Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC68 Gene

Aliases for CCDC68 Gene

  • Coiled-Coil Domain Containing 68 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se57-1 3 4
  • Cutaneous T-Cell Lymphoma Associated Antigen 2 3
  • CTCL-Associated Antigen Se57-1 3 4
  • Coiled-Coil Domain-Containing Protein 68 3
  • CTCL Tumor Antigen Se57-1 3
  • SE57-1 3

External Ids for CCDC68 Gene

Previous GeneCards Identifiers for CCDC68 Gene

  • GC18M050720
  • GC18M052568
  • GC18M049277

Summaries for CCDC68 Gene

GeneCards Summary for CCDC68 Gene

CCDC68 (Coiled-Coil Domain Containing 68) is a Protein Coding gene. Diseases associated with CCDC68 include Cutaneous T Cell Lymphoma.

UniProtKB/Swiss-Prot for CCDC68 Gene

  • Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).

Additional gene information for CCDC68 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC68 Gene

Genomics for CCDC68 Gene

GeneHancer (GH) Regulatory Elements for CCDC68 Gene

Promoters and enhancers for CCDC68 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I054957 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.5 -0.2 -169 5 ATF1 FOXA2 SIN3A FEZF1 BRCA1 ZNF48 ZNF335 GLIS2 EGR1 ATF7 CCDC68 POLI ENSG00000267311 LOC105372124
GH18I054945 Enhancer 1.2 Ensembl ENCODE 14.3 +12.3 12263 3.9 FOXA2 MLX ARID4B DMAP1 YY1 CBX5 ZNF548 SP5 JUNB ZHX2 CCDC68 STARD6 MAP1LC3P ENSG00000267112
GH18I054827 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.8 +130.0 130026 3.5 PKNOX1 ZSCAN4 SIN3A ZNF76 FEZF1 ZNF2 ZNF48 RAD21 ZNF335 ZNF766 RAB27B CCDC68 POLI ENSG00000267311 GC18P054745
GH18I054717 Enhancer 0.9 Ensembl ENCODE dbSUPER 11 +241.4 241407 1 MXI1 POLR2A ZNF143 RUNX3 RAB27B CCDC68 GC18P054727
GH18I054967 Enhancer 0.6 ENCODE 14.1 -9.0 -9022 1.8 GTF3C2 JUND JUN CEBPB RCOR1 EP300 SPI1 TCF7L2 CHD2 CCDC68 ENSG00000267311 LOC105372124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC68 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC68 gene promoter:

Genomic Locations for CCDC68 Gene

Genomic Locations for CCDC68 Gene
chr18:54,901,509-54,959,508
(GRCh38/hg38)
Size:
58,000 bases
Orientation:
Minus strand
chr18:52,568,740-52,626,739
(GRCh37/hg19)

Genomic View for CCDC68 Gene

Genes around CCDC68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC68 Gene

Proteins for CCDC68 Gene

  • Protein details for CCDC68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2F9-CCD68_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 68
    Protein Accession:
    Q9H2F9
    Secondary Accessions:
    • B2R9I3

    Protein attributes for CCDC68 Gene

    Size:
    335 amino acids
    Molecular mass:
    38869 Da
    Quaternary structure:
    • Interacts with CEP170 (PubMed:28422092).

neXtProt entry for CCDC68 Gene

Post-translational modifications for CCDC68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC68 Gene

Domains & Families for CCDC68 Gene

Gene Families for CCDC68 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC68 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC68: view

No data available for UniProtKB/Swiss-Prot for CCDC68 Gene

Function for CCDC68 Gene

Molecular function for CCDC68 Gene

UniProtKB/Swiss-Prot Function:
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).

Phenotypes From GWAS Catalog for CCDC68 Gene

Gene Ontology (GO) - Molecular Function for CCDC68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC68: view
genes like me logo Genes that share phenotypes with CCDC68: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC68 Gene

Localization for CCDC68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC68 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the subdistal appendages of centrioles (PubMed:28422092). {ECO:0000269 PubMed:28422092}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC68 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
golgi apparatus 3
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 28422092
GO:0120103 centriolar subdistal appendage IDA 28422092
genes like me logo Genes that share ontologies with CCDC68: view

Pathways & Interactions for CCDC68 Gene

SuperPathways for CCDC68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IMP 28422092
GO:0034454 microtubule anchoring at centrosome IMP 28422092
genes like me logo Genes that share ontologies with CCDC68: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC68 Gene

Drugs & Compounds for CCDC68 Gene

No Compound Related Data Available

Transcripts for CCDC68 Gene

Unigene Clusters for CCDC68 Gene

Coiled-coil domain containing 68:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC68 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:
SP3:

Relevant External Links for CCDC68 Gene

GeneLoc Exon Structure for
CCDC68
ECgene alternative splicing isoforms for
CCDC68

Expression for CCDC68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC68 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC68 Gene

This gene is overexpressed in Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for CCDC68 Gene

This gene is overexpressed in Adipocyte (45.0) and Platelet (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC68 Gene



Protein tissue co-expression partners for CCDC68 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC68 Gene:

CCDC68

SOURCE GeneReport for Unigene cluster for CCDC68 Gene:

Hs.120790

mRNA Expression by UniProt/SwissProt for CCDC68 Gene:

Q9H2F9-CCD68_HUMAN
Tissue specificity: Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL).
genes like me logo Genes that share expression patterns with CCDC68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC68 Gene

Orthologs for CCDC68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC68 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CCDC68 33 34
  • 87.36 (n)
cow
(Bos Taurus)
Mammalia CCDC68 33 34
  • 86.17 (n)
mouse
(Mus musculus)
Mammalia Ccdc68 33 16 34
  • 78.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCDC68 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC68 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc68 33
  • 57.17 (n)
Species where no ortholog for CCDC68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC68 Gene

ENSEMBL:
Gene Tree for CCDC68 (if available)
TreeFam:
Gene Tree for CCDC68 (if available)

Paralogs for CCDC68 Gene

(1) SIMAP similar genes for CCDC68 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCDC68 Gene

genes like me logo Genes that share paralogs with CCDC68: view

No data available for Paralogs for CCDC68 Gene

Variants for CCDC68 Gene

Sequence variations from dbSNP and Humsavar for CCDC68 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000083187 -- 54,961,314(-) C/T upstream_transcript_variant
rs1000138302 -- 54,939,179(-) C/G intron_variant
rs1000197292 -- 54,951,934(-) G/A intron_variant
rs1000207365 -- 54,925,816(-) C/T 3_prime_UTR_variant, intron_variant
rs1000262488 -- 54,929,012(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC68 Gene

Variant ID Type Subtype PubMed ID
nsv953549 CNV duplication 24416366

Variation tolerance for CCDC68 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC68 Gene

Disorders for CCDC68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC68 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC68

genes like me logo Genes that share disorders with CCDC68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC68 Gene

Publications for CCDC68 Gene

  1. Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer. (PMID: 15142679) Gerhardt A … Eichmüller S (Cancer letters 2004) 2 3 4 58
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmuller S … Schadendorf D (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
  3. Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. (PMID: 28422092) Huang N … Chen J (Nature communications 2017) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CCDC68 Gene

Sources for CCDC68 Gene

Content
Loading form....