Aliases for CCDC61 Gene

Aliases for CCDC61 Gene

  • Coiled-Coil Domain Containing 61 2 3 5
  • Coiled-Coil Domain-Containing Protein 61 3 4
  • CCDC61 5

External Ids for CCDC61 Gene

Previous GeneCards Identifiers for CCDC61 Gene

  • GC19P051191
  • GC19P046498
  • GC19P042926

Summaries for CCDC61 Gene

GeneCards Summary for CCDC61 Gene

CCDC61 (Coiled-Coil Domain Containing 61) is a Protein Coding gene. Diseases associated with CCDC61 include Chondromalacia. An important paralog of this gene is SPTY2D1.

Additional gene information for CCDC61 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC61 Gene

Genomics for CCDC61 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC61 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC61 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC61

Top Transcription factor binding sites by QIAGEN in the CCDC61 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2
  • p53
  • STAT1
  • STAT1alpha

Genomic Locations for CCDC61 Gene

Genomic Locations for CCDC61 Gene
chr19:45,995,457-46,021,318
(GRCh38/hg38)
Size:
25,862 bases
Orientation:
Plus strand
chr19:46,498,339-46,524,576
(GRCh37/hg19)
Size:
26,238 bases
Orientation:
Plus strand

Genomic View for CCDC61 Gene

Genes around CCDC61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC61 Gene

Proteins for CCDC61 Gene

  • Protein details for CCDC61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6R9-CCD61_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 61
    Protein Accession:
    Q9Y6R9
    Secondary Accessions:
    • C8CAP4
    • Q9HDB6

    Protein attributes for CCDC61 Gene

    Size:
    512 amino acids
    Molecular mass:
    57368 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD38244.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD38244.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAF98366.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC61 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC61 Gene

Post-translational modifications for CCDC61 Gene

  • Ubiquitination at Lys480 and Lys364
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC61 Gene

Domains & Families for CCDC61 Gene

Gene Families for CCDC61 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC61 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC61 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 61 (C8CAP4_HUMAN)
  • Coiled-coil domain-containing protein 61 (CCD61_HUMAN)
genes like me logo Genes that share domains with CCDC61: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC61 Gene

Function for CCDC61 Gene

Phenotypes From GWAS Catalog for CCDC61 Gene

genes like me logo Genes that share phenotypes with CCDC61: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC61

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC61 Gene

Localization for CCDC61 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC61 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IBA,IDA 21399614
genes like me logo Genes that share ontologies with CCDC61: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC61 Gene

Pathways & Interactions for CCDC61 Gene

PathCards logo

SuperPathways for CCDC61 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC61 Gene

Drugs & Compounds for CCDC61 Gene

No Compound Related Data Available

Transcripts for CCDC61 Gene

mRNA/cDNA for CCDC61 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC61

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC61 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: -

Relevant External Links for CCDC61 Gene

GeneLoc Exon Structure for
CCDC61

Expression for CCDC61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC61 Gene

Protein differential expression in normal tissues from HIPED for CCDC61 Gene

This gene is overexpressed in Adrenal (53.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC61 Gene



Protein tissue co-expression partners for CCDC61 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC61

SOURCE GeneReport for Unigene cluster for CCDC61 Gene:

Hs.515479

Evidence on tissue expression from TISSUES for CCDC61 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with CCDC61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC61 Gene

Orthologs for CCDC61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC61 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC61 30 31
  • 99.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC61 30 31
  • 89.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC61 30 31
  • 87.61 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc61 30 17 31
  • 84.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc61 30
  • 83.53 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCDC61 31
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC61 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 74 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486261 30
  • 51.69 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc61 30 31
  • 50.75 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 65 (a)
OneToOne
Species where no ortholog for CCDC61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC61 Gene

ENSEMBL:
Gene Tree for CCDC61 (if available)
TreeFam:
Gene Tree for CCDC61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC61: view image

Paralogs for CCDC61 Gene

Paralogs for CCDC61 Gene

genes like me logo Genes that share paralogs with CCDC61: view

Variants for CCDC61 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC61 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
781453 Likely Benign: not provided 46,016,077(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CCDC61 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC61 Gene

Variant ID Type Subtype PubMed ID
esv25420 CNV loss 19812545

Variation tolerance for CCDC61 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC61 Gene

Disorders for CCDC61 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC61 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chondromalacia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC61

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCDC61: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC61 Gene

Publications for CCDC61 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning. (PMID: 31789463) Pizon V … Azimzadeh J (Biology of the cell 2020) 3
  5. A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection. (PMID: 31594818) Yeung ATY … Dougan G (mBio 2019) 3

Products for CCDC61 Gene

Sources for CCDC61 Gene