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CCDC60 Gene(Protein Coding)

Coiled-Coil Domain Containing 60

GCID:
GC12P119334
GIFtS:
39
Genes Participants
UDN Logo

Aliases for CCDC60 Gene

Aliases for CCDC60 Gene

  • Coiled-Coil Domain Containing 60 2 3 5

External Ids for CCDC60 Gene

Previous GeneCards Identifiers for CCDC60 Gene

  • GC12P118238
  • GC12P119772
  • GC12P116780

Summaries for CCDC60 Gene

GeneCards Summary for CCDC60 Gene

CCDC60 (Coiled-Coil Domain Containing 60) is a Protein Coding gene.

Additional gene information for CCDC60 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC60 Gene

Genomics for CCDC60 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CCDC60 Gene

Promoters and enhancers for CCDC60 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I119334 Promoter 0.8 EPDnew 550.8 0.0 -2 0.1 ZNF148 SP1 RFX1 VEZF1 NR2C1 SIN3A NR2C2 CCDC60 LINC00934
GH12I119207 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -126.0 -126027 1.6 RFX1 HLF NEUROD1 CEBPB MNT REST CEBPG BMI1 RFX5 SCRT2 CCDC60 HSPB8 SRRM4 LOC105370026 LOC100287653
GH12I119210 Enhancer 0.2 FANTOM5 2.1 -123.8 -123754 0.3 LOC105370026 CCDC60 GC12P119226 HSPB8
GH12I119413 Enhancer 0.6 ENCODE 0.2 +78.6 78639 0.2 CTCF PKNOX1 ZNF654 TRIM22 SIN3A REST RAD21 CC2D1A ZNF143 SMC3 SRRM4 CCDC60 TMEM233 LOC105370027
GH12I119308 Enhancer 0.4 ENCODE 0.3 -25.5 -25514 0.8 POLR2A PRDM1 LINC00934 CCDC60
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC60 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC60 gene promoter:

Genomic Locations for CCDC60 Gene

Genomic Locations for CCDC60 Gene
chr12:119,334,712-119,541,047
(GRCh38/hg38)
Size:
206,336 bases
Orientation:
Plus strand
chr12:119,772,517-119,978,852
(GRCh37/hg19)

Genomic View for CCDC60 Gene

Genes around CCDC60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC60 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC60 Gene

Proteins for CCDC60 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCDC60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWA6-CCD60_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 60
    Protein Accession:
    Q8IWA6

    Protein attributes for CCDC60 Gene

    Size:
    550 amino acids
    Molecular mass:
    63091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC60 Gene

Protein Expression for CCDC60 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC60 Gene

Domains & Families for CCDC60 Gene

Gene Families for CCDC60 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC60: view

No data available for UniProtKB/Swiss-Prot for CCDC60 Gene

Function for CCDC60 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for CCDC60 Gene

Gene Ontology (GO) - Molecular Function for CCDC60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC60: view
genes like me logo Genes that share phenotypes with CCDC60: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC60 Gene

Localization for CCDC60 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC60 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC60 Gene

Pathways & Interactions for CCDC60 Gene

SuperPathways for CCDC60 Gene

PathCards logo More details on SuperPathways for CCDC60
No Data Available

Interacting Proteins for CCDC60 Gene

Selected Interacting proteins: Q8IWA6-CCD60_HUMAN for CCDC60 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for CCDC60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC60 Gene

Drugs & Compounds for CCDC60 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCDC60 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCDC60 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC60 Gene

Coiled-coil domain containing 60:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC60 Gene

No ASD Table

Relevant External Links for CCDC60 Gene

GeneLoc Exon Structure for
CCDC60
ECgene alternative splicing isoforms for
CCDC60

Expression for CCDC60 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC60 Gene

mRNA expression in normal human tissues for CCDC60 Gene
mRNA expression by GTEx for CCDC60 GenemRNA expression by BioGPS for CCDC60 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC60 Gene

This gene is overexpressed in Testis (x17.6) and Bladder (x5.7).

Protein differential expression in normal tissues from HIPED for CCDC60 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC60 Gene



Protein tissue co-expression partners for CCDC60 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC60 Gene:

CCDC60

SOURCE GeneReport for Unigene cluster for CCDC60 Gene:

Hs.98188
genes like me logo Genes that share expression patterns with CCDC60: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC60 Gene

Orthologs for CCDC60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC60 33 34
  • 99.52 (n)
cow
(Bos Taurus)
 Mammalia CCDC60 33 34
  • 84.65 (n)
dog
(Canis familiaris)
 Mammalia CCDC60 33 34
  • 83.9 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc60 33
  • 78.34 (n)
mouse
(Mus musculus)
 Mammalia Ccdc60 33 16 34
  • 77.76 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCDC60 34
  • 62 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCDC60 33 34
  • 50.17 (n)
lizard
(Anolis carolinensis)
 Reptilia CCDC60 34
  • 37 (a)
 OneToOne
Species where no ortholog for CCDC60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC60 Gene

ENSEMBL:
Gene Tree for CCDC60 (if available)
TreeFam:
Gene Tree for CCDC60 (if available)

Paralogs for CCDC60 Gene

No data available for Paralogs for CCDC60 Gene

Variants for CCDC60 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CCDC60 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005053 -- 119,393,763(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000013209 -- 119,541,448(+) A/G downstream_transcript_variant
rs1000018659 -- 119,400,709(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000033404 -- 119,348,602(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000045336 -- 119,425,909(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC60 Gene

Variant ID Type Subtype PubMed ID
dgv318e199 CNV deletion 23128226
esv2127888 CNV deletion 18987734
esv2674874 CNV deletion 23128226
esv2746459 CNV deletion 23290073
esv3407653 CNV duplication 20981092
esv3549870 CNV deletion 23714750
esv3549871 CNV deletion 23714750
esv3630902 CNV loss 21293372
esv3817 CNV loss 18987735
esv7481 CNV loss 19470904
nsv1035871 CNV gain 25217958
nsv474516 CNV novel sequence insertion 20440878
nsv832528 CNV gain 17160897
nsv832529 CNV loss 17160897

Variation tolerance for CCDC60 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.15; 84.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC60 Gene

Disorders for CCDC60 Gene

Additional Disease Information for CCDC60

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC60 Gene

Publications for CCDC60 Gene

  1. A genome-wide association study in 574 schizophrenia trios using DNA pooling. (PMID: 18332876) Kirov G … O'Donovan MC (Molecular psychiatry 2009) 3 44 58
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for CCDC60 Gene

Sources for CCDC60 Gene

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