Aliases for CCDC59 Gene

Aliases for CCDC59 Gene

  • Coiled-Coil Domain Containing 59 2 3 5
  • TAP26 2 3 4
  • BR22 2 3 4
  • Thyroid Transcription Factor 1-Associated Protein 26 3 4
  • Coiled-Coil Domain-Containing Protein 59 3 4
  • TTF-1-Associated Protein BR2 3 4
  • TTF-1-Associated Protein 26 3 4
  • HSPC128 2 3
  • CCDC59 5

External Ids for CCDC59 Gene

Previous GeneCards Identifiers for CCDC59 Gene

  • GC12M081250
  • GC12M081270
  • GC12M082746
  • GC12M079803
  • GC12M082617

Summaries for CCDC59 Gene

GeneCards Summary for CCDC59 Gene

CCDC59 (Coiled-Coil Domain Containing 59) is a Protein Coding gene. Diseases associated with CCDC59 include Intracystic Papillary Adenoma and Otosclerosis. Among its related pathways are HIV Life Cycle and Metabolism of proteins.

UniProtKB/Swiss-Prot Summary for CCDC59 Gene

  • Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC59 Gene

Genomics for CCDC59 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC59 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J082357 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 309 +0.4 404 3.6 TBP ZBTB10 SP1 MXD4 FEZF1 SIX5 NR2C1 MNT DEK IKZF1 METTL25 CCDC59 lnc-PPFIA2-5 piR-58846 ENSG00000257431 HSALNG0092739 PPFIA2
GH12J082861 Enhancer 1 Ensembl dbSUPER 12 -504.0 -503995 1.2 ZSCAN16 FEZF1 ZIC2 ZNF610 ZNF513 KLF7 ZNF843 PRDM6 KLF16 ZNF2 METTL25 CCDC59 RF00017-1195 piR-30876-029 TMTC2
GH12J081942 Enhancer 0.9 FANTOM5 ENCODE 1.6 +416.2 416211 0.8 NR2C1 TRIM22 SPI1 POLR2A ELF1 IKZF1 BMI1 ATF7 TARDBP IKZF2 piR-31292-033 PPFIA2 CCDC59 lnc-METTL25-5 LINC02426 HSALNG0092723 METTL25
GH12J081955 Enhancer 0.9 FANTOM5 Ensembl 1.3 +401.7 401704 4.2 TRIM22 RFX5 ELF1 IKZF1 ATF7 TARDBP IKZF2 ZNF687 ZBTB33 MTA2 HSALNG0092727 PPFIA2 CCDC59 piR-31937-045 LINC02426 HSALNG0092723 METTL25
GH12J081949 Enhancer 0.3 FANTOM5 1.9 +408.8 408806 0.4 RAD51 lnc-METTL25-5 PPFIA2 CCDC59 piR-31292-033 LINC02426 HSALNG0092723 METTL25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC59 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC59

Top Transcription factor binding sites by QIAGEN in the CCDC59 gene promoter:
  • E47
  • Egr-2
  • FOXJ2 (long isoform)
  • HTF
  • IRF-1
  • Lmo2
  • p53
  • POU3F1
  • STAT5B
  • Tal-1

Genomic Locations for CCDC59 Gene

Latest Assembly
chr12:82,223,681-82,358,805
(GRCh38/hg38)
Size:
135,125 bases
Orientation:
Minus strand

Previous Assembly
chr12:82,746,082-82,752,584
(GRCh37/hg19 by Entrez Gene)
Size:
6,503 bases
Orientation:
Minus strand

chr12:82,617,460-82,752,584
(GRCh37/hg19 by Ensembl)
Size:
135,125 bases
Orientation:
Minus strand

Genomic View for CCDC59 Gene

Genes around CCDC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC59 Gene

Proteins for CCDC59 Gene

  • Protein details for CCDC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P031-TAP26_HUMAN
    Recommended name:
    Thyroid transcription factor 1-associated protein 26
    Protein Accession:
    Q9P031
    Secondary Accessions:
    • Q9H2V5
    • Q9NW62

    Protein attributes for CCDC59 Gene

    Size:
    241 amino acids
    Molecular mass:
    28670 Da
    Quaternary structure:
    • Interacts with NKX2-1.

neXtProt entry for CCDC59 Gene

Post-translational modifications for CCDC59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC59 Gene

Domains & Families for CCDC59 Gene

Gene Families for CCDC59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC59 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC59 Gene

GenScript: Design optimal peptide antigens:
  • TTF-1-associated protein BR2 (TAP26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P031

UniProtKB/Swiss-Prot:

TAP26_HUMAN :
  • Belongs to the TAP26 family.
Family:
  • Belongs to the TAP26 family.
genes like me logo Genes that share domains with CCDC59: view

Function for CCDC59 Gene

Molecular function for CCDC59 Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.

Phenotypes From GWAS Catalog for CCDC59 Gene

Gene Ontology (GO) - Molecular Function for CCDC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 11152647
genes like me logo Genes that share ontologies with CCDC59: view
genes like me logo Genes that share phenotypes with CCDC59: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC59

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC59 Gene

Localization for CCDC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC59 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC59 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
plasma membrane 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoli rim (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCDC59: view

Pathways & Interactions for CCDC59 Gene

genes like me logo Genes that share pathways with CCDC59: view

Gene Ontology (GO) - Biological Process for CCDC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with CCDC59: view

No data available for SIGNOR curated interactions for CCDC59 Gene

Drugs & Compounds for CCDC59 Gene

No Compound Related Data Available

Transcripts for CCDC59 Gene

mRNA/cDNA for CCDC59 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC59

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC59 Gene

No ASD Table

Relevant External Links for CCDC59 Gene

GeneLoc Exon Structure for
CCDC59

Expression for CCDC59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC59 Gene

This gene is overexpressed in Lung (46.6), Pancreas (10.1), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC59 Gene



Protein tissue co-expression partners for CCDC59 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC59

SOURCE GeneReport for Unigene cluster for CCDC59 Gene:

Hs.582627

mRNA Expression by UniProt/SwissProt for CCDC59 Gene:

Q9P031-TAP26_HUMAN
Tissue specificity: Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells.

Evidence on tissue expression from TISSUES for CCDC59 Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with CCDC59: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC59 Gene

Orthologs for CCDC59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC59 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC59 30 31
  • 98.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC59 30 31
  • 85.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC59 30 31
  • 80.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc59 30
  • 78.38 (n)
Mouse
(Mus musculus)
Mammalia Ccdc59 30 17 31
  • 77.68 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CCDC59 30 31
  • 65.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC59 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc59 30
  • 58.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3654 30
Zebrafish
(Danio rerio)
Actinopterygii ccdc59 30 31
  • 51.74 (n)
OneToOne
Species where no ortholog for CCDC59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC59 Gene

ENSEMBL:
Gene Tree for CCDC59 (if available)
TreeFam:
Gene Tree for CCDC59 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC59: view image

Paralogs for CCDC59 Gene

Pseudogenes.org Pseudogenes for CCDC59 Gene

genes like me logo Genes that share paralogs with CCDC59: view

No data available for Paralogs for CCDC59 Gene

Variants for CCDC59 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC59 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs386352284 Uncertain Significance: not provided 82,358,773(-) G/A
NM_032230.3(METTL25):c.208G>A (p.Glu70Lys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC59 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC59 Gene

Variant ID Type Subtype PubMed ID
nsv559539 CNV gain 21841781
nsv559541 CNV gain 21841781
nsv832471 CNV loss 17160897

Variation tolerance for CCDC59 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC59

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC59 Gene

Disorders for CCDC59 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCDC59 Gene - From: COP

Disorder Aliases PubMed IDs
intracystic papillary adenoma
  • intracystic papilloma
otosclerosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC59

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCDC59: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC59 Gene

Publications for CCDC59 Gene

  1. The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells. (PMID: 16630564) Yang MC … Yang YS (Biochemical and biophysical research communications 2006) 2 3 4
  2. BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells. (PMID: 12882447) Yang MC … Yang YS (The European respiratory journal 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter. (PMID: 11152647) Yang YS … Weissler JC (American journal of respiratory cell and molecular biology 2001) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4

Products for CCDC59 Gene

Sources for CCDC59 Gene