Aliases for CCDC58 Gene

Aliases for CCDC58 Gene

  • Coiled-Coil Domain Containing 58 2 3 5
  • Coiled-Coil Domain-Containing Protein 58 3 4

External Ids for CCDC58 Gene

Previous GeneCards Identifiers for CCDC58 Gene

  • GC03M123562
  • GC03M122078
  • GC03M119451

Summaries for CCDC58 Gene

GeneCards Summary for CCDC58 Gene

CCDC58 (Coiled-Coil Domain Containing 58) is a Protein Coding gene.

Additional gene information for CCDC58 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC58 Gene

Genomics for CCDC58 Gene

GeneHancer (GH) Regulatory Elements for CCDC58 Gene

Promoters and enhancers for CCDC58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J122414 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.6 -32.9 -32920 2.8 ZBTB40 ZNF217 EP300 SIN3A TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 WDR5B ENSG00000272758 CCDC58 ENSG00000242531 LOC102723582 FAM162A
GH03J122381 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.5 -507 4 ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 MYC POLR2G NCOR1 FAM162A CCDC58 NONHSAG035895.2 lnc-CCDC58-1 IQCB1 WDR5B ENSG00000272758
GH03J122073 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +305.9 305851 7.1 SIN3A SP1 NCOR1 EP300 RELA MEF2C RCOR1 REST TRIM22 NFYB CD86 ILDR1 ENSG00000202388 DTX3L PARP9 CCDC58 FAM162A IQCB1 EAF2 CSTA
GH03J122482 Promoter/Enhancer 1.2 Ensembl ENCODE 10.3 -99.9 -99887 1.5 SP1 JUND FOS EP300 POLR2A RELA MEF2C TRIM22 BCL11A CBFB ENSG00000275348 lnc-FAM162A-3 WDR5B ENSG00000272758 KPNA1 CCDC58 FAM162A
GH03J122314 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +69.5 69480 4 POLR2A FOS EZH2 HLF GATA3 CTCF ZNF384 MNT STAT3 CSTA WDR5B CCDC58 FAM162A PARP14 ENSG00000272758 PARP9 DTX3L SLC49A4 CD86
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC58 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC58

Top Transcription factor binding sites by QIAGEN in the CCDC58 gene promoter:
  • Arnt
  • ARP-1
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • POU2F1
  • POU2F1a
  • STAT5A
  • USF-1

Genomic Locations for CCDC58 Gene

Genomic Locations for CCDC58 Gene
23,693 bases
Minus strand
23,643 bases
Minus strand

Genomic View for CCDC58 Gene

Genes around CCDC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC58 Gene

Proteins for CCDC58 Gene

  • Protein details for CCDC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 58
    Protein Accession:
    Secondary Accessions:
    • Q32LY6

    Protein attributes for CCDC58 Gene

    144 amino acids
    Molecular mass:
    16620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC58 Gene

Post-translational modifications for CCDC58 Gene

  • Ubiquitination at Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC58 Gene

No data available for DME Specific Peptides for CCDC58 Gene

Domains & Families for CCDC58 Gene

Gene Families for CCDC58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC58 Gene


Suggested Antigen Peptide Sequences for CCDC58 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 58 (CCD58_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC58 family.
  • Belongs to the CCDC58 family.
genes like me logo Genes that share domains with CCDC58: view

Function for CCDC58 Gene

Phenotypes From GWAS Catalog for CCDC58 Gene

genes like me logo Genes that share phenotypes with CCDC58: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC58 Gene

Localization for CCDC58 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC58 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC58 Gene

Pathways & Interactions for CCDC58 Gene

PathCards logo

SuperPathways for CCDC58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC58 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC58 Gene

Drugs & Compounds for CCDC58 Gene

No Compound Related Data Available

Transcripts for CCDC58 Gene

mRNA/cDNA for CCDC58 Gene

5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC58 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for CCDC58 Gene

GeneLoc Exon Structure for

Expression for CCDC58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC58 Gene

Protein differential expression in normal tissues from HIPED for CCDC58 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Liver (6.7), and Liver, secretome (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC58 Gene

Protein tissue co-expression partners for CCDC58 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC58

SOURCE GeneReport for Unigene cluster for CCDC58 Gene:

genes like me logo Genes that share expression patterns with CCDC58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC58 Gene

Orthologs for CCDC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC58 30
  • 99.54 (n)
(Bos Taurus)
Mammalia CCDC58 31 30
  • 96.53 (n)
(Canis familiaris)
Mammalia CCDC58 31 30
  • 96.06 (n)
(Rattus norvegicus)
Mammalia Ccdc58 30
  • 95.6 (n)
(Mus musculus)
Mammalia Ccdc58 17 31 30
  • 94.68 (n)
(Monodelphis domestica)
Mammalia CCDC58 31
  • 88 (a)
(Gallus gallus)
Aves CCDC58 31 30
  • 83.1 (n)
(Anolis carolinensis)
Reptilia CCDC58 31
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc58 30
  • 72.92 (n)
Str.6520 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7053 30
(Danio rerio)
Actinopterygii ccdc58 31 30
  • 70.56 (n)
zgc73369 30
fruit fly
(Drosophila melanogaster)
Insecta CG15881 31 30
  • 50.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005402 30
  • 50.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5031 31
  • 44 (a)
Species where no ortholog for CCDC58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC58 Gene

Gene Tree for CCDC58 (if available)
Gene Tree for CCDC58 (if available)
Evolutionary constrained regions (ECRs) for CCDC58: view image

Paralogs for CCDC58 Gene

No data available for Paralogs for CCDC58 Gene

Variants for CCDC58 Gene

Additional dbSNP identifiers (rs#s) for CCDC58 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC58 Gene

Variant ID Type Subtype PubMed ID
esv2574672 CNV deletion 19546169
esv2677337 CNV deletion 23128226
esv33139 CNV loss 17666407
esv3568993 CNV loss 25503493
esv3597607 CNV loss 21293372
nsv3973 CNV deletion 18451855

Variation tolerance for CCDC58 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC58 Gene

Disorders for CCDC58 Gene

Additional Disease Information for CCDC58

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC58 Gene

Publications for CCDC58 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 54
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 54

Products for CCDC58 Gene

  • Biorbyt antibodies for CCDC58

Sources for CCDC58 Gene