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Aliases for CCDC42 Gene

Aliases for CCDC42 Gene

  • Coiled-Coil Domain Containing 42 2 3 5
  • CCDC42A 3 4
  • Coiled-Coil Domain-Containing Protein 42A 3
  • Coiled-Coil Domain-Containing Protein 42 3

External Ids for CCDC42 Gene

Previous GeneCards Identifiers for CCDC42 Gene

  • GC17M008575

Summaries for CCDC42 Gene

GeneCards Summary for CCDC42 Gene

CCDC42 (Coiled-Coil Domain Containing 42) is a Protein Coding gene. An important paralog of this gene is CFAP73.

UniProtKB/Swiss-Prot for CCDC42 Gene

  • Required for sperm development.

Additional gene information for CCDC42 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC42 Gene

Genomics for CCDC42 Gene

GeneHancer (GH) Regulatory Elements for CCDC42 Gene

Promoters and enhancers for CCDC42 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I008744 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 584.2 -0.4 -376 1.9 HDGF ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF213 ZNF143 KLF13 SP3 CCDC42 LOC105371529 SPDYE4 ODF4 MFSD6L
GH17I008364 Enhancer 0.9 FANTOM5 Ensembl ENCODE 53.6 +379.2 379243 2.4 STAT1 POLR2A JUN ZNF600 ATF2 ENSG00000265749 ODF4 CCDC42 SPDYE4 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17I008695 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +47.5 47534 3.6 CTCF ZNF2 RAD21 ETS1 ZFHX2 EGR1 EZH2 EGR2 L3MBTL2 NRF1 MYH10 CCDC42 SPDYE4 LOC105371526 LOC105371525
GH17I008723 Enhancer 0.5 ENCODE 24.3 +20.5 20530 2.2 HLF CEBPA CEBPB MNT CEBPG CCDC42 MYH10 SPDYE4 RNF222 BORCS6 PIR61588 LOC105371529
GH17I008706 Enhancer 1 Ensembl ENCODE dbSUPER 10 +37.1 37050 2.6 TFAP4 FOXA2 RXRA TEAD1 THRB NR2F2 RARA TEAD3 SKI ZNF217 SPDYE4 CCDC42 LOC105371526 LOC105371525
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC42 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC42 gene promoter:

Genomic Locations for CCDC42 Gene

Genomic Locations for CCDC42 Gene
15,292 bases
Minus strand

Genomic View for CCDC42 Gene

Genes around CCDC42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC42 Gene

Proteins for CCDC42 Gene

  • Protein details for CCDC42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 42
    Protein Accession:
    Secondary Accessions:
    • Q8N6Q0

    Protein attributes for CCDC42 Gene

    316 amino acids
    Molecular mass:
    38019 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC42 Gene


neXtProt entry for CCDC42 Gene

Post-translational modifications for CCDC42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC42 Gene

No data available for DME Specific Peptides for CCDC42 Gene

Domains & Families for CCDC42 Gene

Gene Families for CCDC42 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC42 Gene


Suggested Antigen Peptide Sequences for CCDC42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CFAP73 family.
  • Belongs to the CFAP73 family.
genes like me logo Genes that share domains with CCDC42: view

Function for CCDC42 Gene

Molecular function for CCDC42 Gene

UniProtKB/Swiss-Prot Function:
Required for sperm development.

Phenotypes From GWAS Catalog for CCDC42 Gene

Gene Ontology (GO) - Molecular Function for CCDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC42: view
genes like me logo Genes that share phenotypes with CCDC42: view

Animal Models for CCDC42 Gene

MGI Knock Outs for CCDC42:

Animal Model Products

miRNA for CCDC42 Gene

miRTarBase miRNAs that target CCDC42

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC42 Gene

Localization for CCDC42 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC42 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC42 Gene

Pathways & Interactions for CCDC42 Gene

SuperPathways for CCDC42 Gene

No Data Available

Interacting Proteins for CCDC42 Gene

Gene Ontology (GO) - Biological Process for CCDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development ISS --
genes like me logo Genes that share ontologies with CCDC42: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC42 Gene

Drugs & Compounds for CCDC42 Gene

No Compound Related Data Available

Transcripts for CCDC42 Gene

mRNA/cDNA for CCDC42 Gene

Unigene Clusters for CCDC42 Gene

Coiled-coil domain containing 42:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC42 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP2: -
SP3: -

Relevant External Links for CCDC42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC42 Gene

This gene is overexpressed in Testis (x50.1).

Protein differential expression in normal tissues from HIPED for CCDC42 Gene

This gene is overexpressed in Cerebrospinal fluid (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC42 Gene

Protein tissue co-expression partners for CCDC42 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC42 Gene:


SOURCE GeneReport for Unigene cluster for CCDC42 Gene:


Evidence on tissue expression from TISSUES for CCDC42 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CCDC42: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC42 Gene

Orthologs for CCDC42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC42 33 34
  • 99.58 (n)
(Bos Taurus)
Mammalia CCDC42 33 34
  • 88.08 (n)
(Canis familiaris)
Mammalia CCDC42 33 34
  • 86.6 (n)
(Mus musculus)
Mammalia Ccdc42 33 16 34
  • 84.92 (n)
(Rattus norvegicus)
Mammalia Ccdc42 33
  • 84.07 (n)
(Monodelphis domestica)
Mammalia CCDC42 34
  • 81 (a)
(Gallus gallus)
Aves CCDC42 33 34
  • 62.87 (n)
(Anolis carolinensis)
Reptilia CCDC42 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145050 33
  • 52.93 (n)
(Danio rerio)
Actinopterygii LOC100001777 33
  • 50.59 (n)
ccdc42b 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4208 34
  • 46 (a)
Species where no ortholog for CCDC42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC42 Gene

Gene Tree for CCDC42 (if available)
Gene Tree for CCDC42 (if available)

Paralogs for CCDC42 Gene

Paralogs for CCDC42 Gene

(1) SIMAP similar genes for CCDC42 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC42: view

Variants for CCDC42 Gene

Sequence variations from dbSNP and Humsavar for CCDC42 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000518264 -- 8,731,993(-) T/C intron_variant
rs1001103404 -- 8,736,868(-) G/A intron_variant
rs1001270575 -- 8,742,260(-) G/A intron_variant
rs1001317078 -- 8,730,631(-) C/T intron_variant
rs1001516177 -- 8,734,997(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC42 Gene

Variant ID Type Subtype PubMed ID
esv2761945 CNV loss 21179565
esv3892957 CNV loss 25118596
nsv518675 CNV gain 19592680

Variation tolerance for CCDC42 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC42 Gene

Disorders for CCDC42 Gene

Additional Disease Information for CCDC42

No disorders were found for CCDC42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC42 Gene

Publications for CCDC42 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H … D'Andrea AD (Molecular cell 2014) 3 58
  5. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. (PMID: 20622878) Remmers EF … Gül A (Nature genetics 2010) 44 58

Products for CCDC42 Gene

Sources for CCDC42 Gene

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