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Aliases for CCDC38 Gene

Aliases for CCDC38 Gene

  • Coiled-Coil Domain Containing 38 2 3 5

External Ids for CCDC38 Gene

Previous GeneCards Identifiers for CCDC38 Gene

  • GC12M094764
  • GC12M096260
  • GC12M093325

Summaries for CCDC38 Gene

GeneCards Summary for CCDC38 Gene

CCDC38 (Coiled-Coil Domain Containing 38) is a Protein Coding gene. An important paralog of this gene is CFAP100.

Additional gene information for CCDC38 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC38 Gene

Genomics for CCDC38 Gene

GeneHancer (GH) Regulatory Elements for CCDC38 Gene

Promoters and enhancers for CCDC38 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I095941 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 88 2.4 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 SP3 SP5 AMDHD1 CCDC38 NR2C1 USP44 ELK3 METAP2 SNRPF VEZT LTA4H HAL
GH12I095858 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +83.9 83910 2.3 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 LOC105369921 SNRPF PIR48032 CCDC38 AMDHD1
GH12I095994 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.5 -52.7 -52747 2.4 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 ELK1 ATF7 RXRA HAL LOC102723340 AMDHD1 CCDC38 GC12M095983
GH12I095965 Enhancer 0.9 ENCODE 12.6 -23.3 -23321 1.9 FOXA2 MLX ARID4B ZNF48 ZSCAN9 RAD21 RARA ETS1 YY1 THAP11 AMDHD1 HAL CCDC38 GC12M095961 GC12M095983
GH12I095972 Enhancer 0.9 ENCODE 10.8 -30.2 -30234 2.8 FOXA2 MLX ARID4B SLC30A9 SP5 MXD4 PPARG KAT8 NFIL3 MAFF HAL CCDC38 AMDHD1 LOC102723340 GC12M095983 GC12M095961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC38 gene promoter:

Genomic Locations for CCDC38 Gene

Genomic Locations for CCDC38 Gene
76,207 bases
Minus strand

Genomic View for CCDC38 Gene

Genes around CCDC38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC38 Gene

Proteins for CCDC38 Gene

  • Protein details for CCDC38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 38
    Protein Accession:
    Secondary Accessions:
    • Q8N835

    Protein attributes for CCDC38 Gene

    563 amino acids
    Molecular mass:
    65315 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC38 Gene

Post-translational modifications for CCDC38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC38 Gene

Domains & Families for CCDC38 Gene

Gene Families for CCDC38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC38 Gene


Suggested Antigen Peptide Sequences for CCDC38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC38: view

No data available for UniProtKB/Swiss-Prot for CCDC38 Gene

Function for CCDC38 Gene

Phenotypes From GWAS Catalog for CCDC38 Gene

genes like me logo Genes that share phenotypes with CCDC38: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC38 Gene

Localization for CCDC38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC38 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC38 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC38: view

Pathways & Interactions for CCDC38 Gene

SuperPathways for CCDC38 Gene

No Data Available

Interacting Proteins for CCDC38 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000345470 for CCDC38 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CCDC38 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC38 Gene

Drugs & Compounds for CCDC38 Gene

No Compound Related Data Available

Transcripts for CCDC38 Gene

mRNA/cDNA for CCDC38 Gene

Unigene Clusters for CCDC38 Gene

Coiled-coil domain containing 38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC38 Gene

No ASD Table

Relevant External Links for CCDC38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC38 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC38 Gene

This gene is overexpressed in Testis (x35.5) and Liver (x6.7).

Protein differential expression in normal tissues from HIPED for CCDC38 Gene

This gene is overexpressed in Stomach (25.7), Serum (24.0), Heart (10.5), and Bone marrow mesenchymal stem cell (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC38 Gene

Protein tissue co-expression partners for CCDC38 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC38 Gene:


SOURCE GeneReport for Unigene cluster for CCDC38 Gene:

genes like me logo Genes that share expression patterns with CCDC38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC38 Gene

Orthologs for CCDC38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC38 33 34
  • 98.99 (n)
(Canis familiaris)
Mammalia CCDC38 33 34
  • 83.18 (n)
(Bos Taurus)
Mammalia CCDC38 33 34
  • 81.84 (n)
(Rattus norvegicus)
Mammalia Ccdc38 33
  • 76.74 (n)
(Mus musculus)
Mammalia Ccdc38 33 16 34
  • 75.91 (n)
(Monodelphis domestica)
Mammalia CCDC38 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
-- 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for CCDC38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC38 Gene

Gene Tree for CCDC38 (if available)
Gene Tree for CCDC38 (if available)

Paralogs for CCDC38 Gene

Paralogs for CCDC38 Gene

(1) SIMAP similar genes for CCDC38 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CCDC38: view

Variants for CCDC38 Gene

Sequence variations from dbSNP and Humsavar for CCDC38 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005429 -- 95,877,887(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000022635 -- 95,906,749(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000034142 -- 95,868,257(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000086146 -- 95,925,480(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000098398 -- 95,880,733(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC38 Gene

Variant ID Type Subtype PubMed ID
dgv295e214 CNV loss 21293372
esv3580384 CNV loss 25503493
esv3630439 CNV gain 21293372
esv3630440 CNV gain 21293372
esv3630443 CNV gain 21293372
nsv455693 CNV loss 19166990
nsv455694 CNV loss 19166990
nsv559834 CNV loss 21841781
nsv559835 CNV loss 21841781
nsv559836 CNV loss 21841781
nsv7234 OTHER inversion 18451855
nsv834 CNV deletion 18451855

Variation tolerance for CCDC38 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC38 Gene

Disorders for CCDC38 Gene

Additional Disease Information for CCDC38

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC38 Gene

Publications for CCDC38 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 58
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CCDC38 Gene

Sources for CCDC38 Gene

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