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CCDC34 Gene(Protein Coding)

Coiled-Coil Domain Containing 34

GCID:
GC11M027327
GIFtS:
37
Genes Participants
UDN Logo

Aliases for CCDC34 Gene

Aliases for CCDC34 Gene

  • Coiled-Coil Domain Containing 34 2 3 5
  • Coiled-Coil Domain-Containing Protein 34 3 4
  • Renal Carcinoma Antigen NY-REN-41 3 4
  • RAMA3 3 4
  • NY-REN-41 Antigen 3
  • NY-REN-41 3
  • L15 3

External Ids for CCDC34 Gene

Previous GeneCards Identifiers for CCDC34 Gene

  • GC11M027057

Summaries for CCDC34 Gene

GeneCards Summary for CCDC34 Gene

CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene.

Additional gene information for CCDC34 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC34 Gene

Genomics for CCDC34 Gene

GeneHancer (GH) Regulatory Elements for CCDC34 Gene

Promoters and enhancers for CCDC34 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J027360 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.9 906 3.6 ZFX ELF3 ZKSCAN8 MNT NKRF ZNF121 GTF2F1 CSDE1 ZNF687 MAFK CCDC34 ENSG00000254862 GC11P027360
GH11J027211 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6 +147.1 147080 8.9 ZNF652 ZNF384 ZNF687 MAFK SP7 IKZF1 POLR2A PKNOX1 ZBTB8A RFX1 SLC5A12 BBOX1-AS1 CCDC34 LIN7C LOC105376600 GC11P027127
GH11J027227 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.2 +134.1 134054 3.2 SCRT2 ZBTB44 ZNF10 ATF2 BBOX1-AS1 CCDC34 LIN7C LOC105376600 LOC105376601
GH11J027290 Enhancer 1 Ensembl ENCODE 4.3 +68.9 68906 6.8 CTCF MAFK TRIM24 SP1 PRDM1 RAD21 ZNF547 ZBTB33 RXRA NFE2L2 LOC105376601 BBOX1-AS1 CCDC34 BDNF
GH11J027253 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +108.5 108458 2.4 POLR2A JUND BDNF BBOX1-AS1 CCDC34 LOC105376601
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC34 gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2C

Genomic Locations for CCDC34 Gene

Genomic Locations for CCDC34 Gene
chr11:27,330,827-27,363,248
(GRCh38/hg38)
Size:
32,422 bases
Orientation:
Minus strand
chr11:27,352,374-27,385,415
(GRCh37/hg19)
Size:
33,042 bases
Orientation:
Minus strand

Genomic View for CCDC34 Gene

Genes around CCDC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC34 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC34 Gene

Proteins for CCDC34 Gene

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  • Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HJ3-CCD34_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 34
    Protein Accession:
    Q96HJ3
    Secondary Accessions:
    • B2R8G2
    • Q8IX69
    • Q9H2A6
    • Q9Y599

    Protein attributes for CCDC34 Gene

    Size:
    373 amino acids
    Molecular mass:
    43225 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
    SequenceCaution:
    • Sequence=AAD42874.1; Type=Frameshift; Positions=9, 21; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Positions=142, 243; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC34 Gene

Protein Expression for CCDC34 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC34 Gene

Domains & Families for CCDC34 Gene

Gene Families for CCDC34 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CCDC34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC34 Gene

GenScript: Design optimal peptide antigens:
  • Renal carcinoma antigen NY-REN-41 (CCD34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC34: view

No data available for UniProtKB/Swiss-Prot for CCDC34 Gene

Function for CCDC34 Gene

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  2. CRISPR
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  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for CCDC34 Gene

genes like me logo Genes that share phenotypes with CCDC34: view

Animal Model Products

CRISPR Products

miRNA for CCDC34 Gene

miRTarBase miRNAs that target CCDC34

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC34 - Now 50% OFF >
  • * CCDC34 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC34 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC34 Gene

Localization for CCDC34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC34 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene

Pathways & Interactions for CCDC34 Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
PathCards logo

SuperPathways for CCDC34 Gene

No Data Available

Interacting Proteins for CCDC34 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 10)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330240%0d9606.ENSP00000376872%0d9606.ENSP00000360922%0d9606.ENSP00000360525%0d9606.ENSP00000302886%0d9606.ENSP00000355741%0d
Selected Interacting proteins: ENSP00000330240 Q96HJ3-CCD34_HUMAN for CCDC34 Gene via STRING IID

GPS-Prot Interaction Network for CCDC34

Gene Ontology (GO) - Biological Process for CCDC34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC34 Gene

Drugs & Compounds for CCDC34 Gene

Products:

  1. Drug
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
No Compound Related Data Available

Transcripts for CCDC34 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCDC34 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CCDC34 Gene

Coiled-coil domain containing 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC34 - Now 50% OFF >
  • * CCDC34 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC34 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC34 Gene

No ASD Table

Relevant External Links for CCDC34 Gene

GeneLoc Exon Structure for
CCDC34
ECgene alternative splicing isoforms for
CCDC34

Expression for CCDC34 Gene

Products:

  1. Primer
  2. Gene Expression Assay
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC34 Gene

mRNA expression in normal human tissues for CCDC34 Gene
mRNA expression by GTEx for CCDC34 GenemRNA expression by BioGPS for CCDC34 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene

This gene is overexpressed in Testis (x6.8).

Protein differential expression in normal tissues from HIPED for CCDC34 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC34 Gene



Protein tissue co-expression partners for CCDC34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC34 Gene:

CCDC34

SOURCE GeneReport for Unigene cluster for CCDC34 Gene:

Hs.143733
genes like me logo Genes that share expression patterns with CCDC34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC34 Gene

Orthologs for CCDC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC34 35 34
  • 99.55 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CCDC34 35 34
  • 86.94 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CCDC34 35 34
  • 84.4 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ccdc34 17 35 34
  • 80.04 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc34 34
  • 79.13 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CCDC34 35
  • 65 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CCDC34 35
  • 42 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCDC34 35 34
  • 67.19 (n)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ccdc34 34
  • 57.2 (n)
zebrafish
(Danio rerio)
 Actinopterygii CCDC34 35
  • 28 (a)
 OneToOne
Species where no ortholog for CCDC34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC34 Gene

ENSEMBL:
Gene Tree for CCDC34 (if available)
TreeFam:
Gene Tree for CCDC34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC34: view image

Paralogs for CCDC34 Gene

Pseudogenes.org Pseudogenes for CCDC34 Gene

genes like me logo Genes that share paralogs with CCDC34: view

No data available for Paralogs for CCDC34 Gene

Variants for CCDC34 Gene

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  1. SNP Genotyping and Copy Number Assay
VarElect - NGS phenotyper. Rapid prioritization of variants from NGS data powered by 100+ GeneCards sources

Sequence variations from dbSNP and Humsavar for CCDC34 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000147449 -- 27,344,176(-) AAAAAAA/AAAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000159123 -- 27,341,332(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000276507 -- 27,341,063(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000439990 -- 27,343,597(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000497902 -- 27,339,593(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC34 Gene

Variant ID Type Subtype PubMed ID
nsv467782 CNV gain 19166990
nsv553914 CNV gain 21841781

Variation tolerance for CCDC34 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC34 Gene

Disorders for CCDC34 Gene

UniProtKB/Swiss-Prot

CCD34_HUMAN
  • Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2). {ECO:0000269 PubMed:11173847}.

Additional Disease Information for CCDC34

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC34 Gene.

No data available for MalaCards and Genatlas for CCDC34 Gene

Publications for CCDC34 Gene

  1. Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K … Gal A (Cytogenetics and cell genetics 2000) 2 3 4 58
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58
  3. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4 58
  4. High Expression of CCDC34 Is Associated with Poor Survival in Cervical Cancer Patients. (PMID: 30458457) Liu LB … Li SJ (Medical science monitor : international medical journal of experimental and clinical research 2018) 3 58
  5. Overexpression of CCDC34 in colorectal cancer and its involvement in tumor growth, apoptosis and invasion. (PMID: 29115580) Geng W … Zhang L (Molecular medicine reports 2018) 3 58

ExternalLinks

View latest publications for CCDC34 gene in Mastermind

Products for CCDC34 Gene

Sources for CCDC34 Gene

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