Free for academic non-profit institutions. Other users need a Commercial license
Aliases for CCDC34 Gene
Aliases for CCDC34 Gene
External Ids for CCDC34 Gene
- HGNC: 25079
- Entrez Gene: 91057
- Ensembl: ENSG00000109881
- OMIM: 612324
- UniProtKB: Q96HJ3
Previous GeneCards Identifiers for CCDC34 Gene
- GC11M027057
Summaries for CCDC34 Gene
GeneCards Summary for CCDC34 Gene
CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene. Diseases associated with CCDC34 include Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome.
Additional gene information for CCDC34 Gene
- HGNC(25079)
- Entrez Gene(91057)
- Ensembl(ENSG00000109881)
- OMIM(612324)
- UniProtKB(Q96HJ3)
- Open Targets Platform(ENSG00000109881)
- Search for CCDC34 at DataMed
- Search for CCDC34 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC34 Gene
Genomics for CCDC34 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCDC34 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCDC34 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC34
- Top Transcription factor binding sites by QIAGEN in the CCDC34 gene promoter:
-
- GATA-1
- GATA-2
- GATA-3
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2C
Genomic Locations for CCDC34 Gene
Genomic Locations for CCDC34 Gene
- chr11:27,330,827-27,363,248
- (GRCh38/hg38)
- Size:
- 32,422 bases
- Orientation:
- Minus strand
- chr11:27,352,374-27,385,415
- (GRCh37/hg19)
- Size:
- 33,042 bases
- Orientation:
- Minus strand
Genomic View for CCDC34 Gene
Genes around CCDC34 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p14.1 by HGNC
- 11p14.1 by Entrez Gene
- 11p14.1 by Ensembl
CCDC34 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC34 Gene
Proteins for CCDC34 Gene
-
Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96HJ3-CCD34_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 34
- Protein Accession:
- Q96HJ3
- B2R8G2
- Q8IX69
- Q9H2A6
- Q9Y599
Protein attributes for CCDC34 Gene
- Size:
- 373 amino acids
- Molecular mass:
- 43225 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD42874.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
Protein Expression for CCDC34 Gene
Post-translational modifications for CCDC34 Gene
Other Protein References for CCDC34 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCDC34
- Invitrogen Antibodies for CCDC34 (AFLGC-CCDC34)
- antibodies-online: Show 21 available CCDC34 Antibodies ranked by validation data
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC34
- Origene Custom Protein Services for CCDC34
No data available for DME Specific Peptides for CCDC34 Gene
Domains & Families for CCDC34 Gene
Gene Families for CCDC34 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CCDC34 Gene
- GenScript: Design optimal peptide antigens:
-
- Renal carcinoma antigen NY-REN-41 (CCD34_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC34 Gene
Function for CCDC34 Gene
Phenotypes From GWAS Catalog for CCDC34 Gene
Phenotypes for CCDC34 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCDC34 - Select products 50% OFF >
- * CCDC34 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCDC34
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC34
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC34
miRNA for CCDC34 Gene
- miRTarBase miRNAs that target CCDC34
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC34
- Browse OriGene Inhibitory RNA Products For CCDC34
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34
Clone Products
- Applied Biological Materials (abm): Clones for CCDC34 - Select products 50% OFF >
- * CCDC34 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCDC34
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC34
Cell Line Products
-
Horizon Cell Lines for CCDC34
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC34 Gene
Localization for CCDC34 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
- Nuclear membrane (2)
- Nucleoli fibrillar center (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene
Pathways & Interactions for CCDC34 Gene
Interacting Proteins for CCDC34 Gene
Selected Interacting proteins:
Q96HJ3-CCD34_HUMAN
ENSP00000330240
for CCDC34 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CCDC34
No data available for Pathways by source and SIGNOR curated interactions for CCDC34 Gene
Transcripts for CCDC34 Gene
mRNA/cDNA for CCDC34 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000529615 716 nts (view in UCSC)
- ENST00000328697 1452 nts (view in UCSC)
- ENST00000317945 2109 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCDC34 - Select products 50% OFF >
- * CCDC34 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCDC34
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC34
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC34
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC34
- Browse OriGene Inhibitory RNA Products For CCDC34
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34
Clone Products
- Applied Biological Materials (abm): Clones for CCDC34 - Select products 50% OFF >
- * CCDC34 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCDC34
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC34
Relevant External Links for CCDC34 Gene
- GeneLoc Exon Structure for
- CCDC34
Expression for CCDC34 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene
This gene is overexpressed in Testis (x6.8).
This gene is overexpressed in Plasma (67.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC34 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC34
SOURCE GeneReport for Unigene cluster for CCDC34 Gene:
Hs.143733Primer Products
-
OriGene qPCR primer pairs for CCDC34
-
OriGene qPCR primer pairs and template standards for CCDC34
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC34 Gene
Orthologs for CCDC34 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCDC34 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CCDC34 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CCDC34 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ccdc34 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ccdc34 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC34 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CCDC34 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CCDC34 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ccdc34 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CCDC34 31 |
|
OneToOne |
- Species where no ortholog for CCDC34 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CCDC34 Gene
- ENSEMBL:
- Gene Tree for CCDC34 (if available)
- TreeFam:
- Gene Tree for CCDC34 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCDC34: view image
Paralogs for CCDC34 Gene
Pseudogenes.org Pseudogenes for CCDC34 Gene
No data available for Paralogs for CCDC34 Gene
Variants for CCDC34 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC34 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11549824 | - | p.Pro53Ser | |||
| rs12364852 | - | p.His192Asn | |||
| rs16925453 | - | p.Ile319Val | |||
| rs17244028 | - | p.Glu264Ala |
Residual Variation Intolerance Score:
47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.87;
87.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCDC34 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC34
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC34 Gene
Disorders for CCDC34 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome |
|
|
Search CCDC34 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CCD34_HUMAN- Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2). {ECO:0000269 PubMed:11173847}.
Additional Disease Information for CCDC34
No data available for Genatlas for CCDC34 Gene
Publications for CCDC34 Gene
- Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K … Gal A (Cytogenetics and cell genetics 2000) 2 3 4
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4
- Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Overexpression of Coiled-Coil Domain-Containing Protein 34 (CCDC34) and its Correlation with Angiogenesis in Esophageal Squamous Cell Carcinoma. (PMID: 29397026) Hu DD … Hu B (Medical science monitor : international medical journal of experimental and clinical research 2018) 3
ExternalLinks
Products for CCDC34 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC34
- Origene Custom Protein Services for CCDC34
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC34
- Browse OriGene Inhibitory RNA Products For CCDC34
- OriGene qPCR primer pairs for CCDC34
- OriGene qPCR primer pairs and template standards for CCDC34
- OriGene CRISPR knockouts for CCDC34
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCDC34
- Sino Biological Human cDNA Clone for CCDC34
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCDC34
- Novus Biologicals proteins and lysates for CCDC34
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for CCDC34 (AFLGC-CCDC34)
- VectorBuilder Custom and pre-made DNA vectors for CCDC34 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCDC34 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCDC34 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCDC34 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCDC34
- antibodies-online: Show 21 available CCDC34 Antibodies ranked by validation data
- antibodies-online: Search results for available CCDC34 related products ranked by validation data
- antibodies-online: Search results for available CCDC34 related products ranked by validation data
- Horizon Cell Lines for CCDC34
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC34
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC34
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCDC34
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34
Sources for CCDC34 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB