Aliases for CCDC34 Gene

Aliases for CCDC34 Gene

  • Coiled-Coil Domain Containing 34 2 3 5
  • RAMA3 2 3 4
  • Coiled-Coil Domain-Containing Protein 34 3 4
  • Renal Carcinoma Antigen NY-REN-41 3 4
  • NY-REN-41 2 3
  • L15 2 3
  • NY-REN-41 Antigen 3
  • CCDC34 5

External Ids for CCDC34 Gene

Previous GeneCards Identifiers for CCDC34 Gene

  • GC11M027057

Summaries for CCDC34 Gene

GeneCards Summary for CCDC34 Gene

CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene. Diseases associated with CCDC34 include Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome.

Additional gene information for CCDC34 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC34 Gene

Genomics for CCDC34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC34 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC34

Top Transcription factor binding sites by QIAGEN in the CCDC34 gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2C

Genomic Locations for CCDC34 Gene

Genomic Locations for CCDC34 Gene
chr11:27,330,827-27,363,248
(GRCh38/hg38)
Size:
32,422 bases
Orientation:
Minus strand
chr11:27,352,374-27,385,415
(GRCh37/hg19)
Size:
33,042 bases
Orientation:
Minus strand

Genomic View for CCDC34 Gene

Genes around CCDC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC34 Gene

Proteins for CCDC34 Gene

  • Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HJ3-CCD34_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 34
    Protein Accession:
    Q96HJ3
    Secondary Accessions:
    • B2R8G2
    • Q8IX69
    • Q9H2A6
    • Q9Y599

    Protein attributes for CCDC34 Gene

    Size:
    373 amino acids
    Molecular mass:
    43225 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD42874.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

    Alternative splice isoforms for CCDC34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC34 Gene

Post-translational modifications for CCDC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC34 Gene

Domains & Families for CCDC34 Gene

Gene Families for CCDC34 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CCDC34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC34 Gene

GenScript: Design optimal peptide antigens:
  • Renal carcinoma antigen NY-REN-41 (CCD34_HUMAN)
genes like me logo Genes that share domains with CCDC34: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC34 Gene

Function for CCDC34 Gene

Phenotypes From GWAS Catalog for CCDC34 Gene

genes like me logo Genes that share phenotypes with CCDC34: view

Animal Model Products

CRISPR Products

miRNA for CCDC34 Gene

miRTarBase miRNAs that target CCDC34

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC34 Gene

Localization for CCDC34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC34 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene

Pathways & Interactions for CCDC34 Gene

PathCards logo

SuperPathways for CCDC34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC34 Gene

Drugs & Compounds for CCDC34 Gene

No Compound Related Data Available

Transcripts for CCDC34 Gene

mRNA/cDNA for CCDC34 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC34 Gene

No ASD Table

Relevant External Links for CCDC34 Gene

GeneLoc Exon Structure for
CCDC34

Expression for CCDC34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC34 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene

This gene is overexpressed in Testis (x6.8).

Protein differential expression in normal tissues from HIPED for CCDC34 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC34 Gene



Protein tissue co-expression partners for CCDC34 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC34

SOURCE GeneReport for Unigene cluster for CCDC34 Gene:

Hs.143733
genes like me logo Genes that share expression patterns with CCDC34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC34 Gene

Orthologs for CCDC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC34 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC34 30 31
  • 99.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC34 30 31
  • 86.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC34 30 31
  • 84.4 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc34 30 17 31
  • 80.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc34 30
  • 79.13 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC34 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC34 31
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC34 30 31
  • 67.19 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc34 30
  • 57.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii CCDC34 31
  • 28 (a)
OneToOne
Species where no ortholog for CCDC34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC34 Gene

ENSEMBL:
Gene Tree for CCDC34 (if available)
TreeFam:
Gene Tree for CCDC34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC34: view image

Paralogs for CCDC34 Gene

Pseudogenes.org Pseudogenes for CCDC34 Gene

genes like me logo Genes that share paralogs with CCDC34: view

No data available for Paralogs for CCDC34 Gene

Variants for CCDC34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC34 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11549824 - p.Pro53Ser
rs12364852 - p.His192Asn
rs16925453 - p.Ile319Val
rs17244028 - p.Glu264Ala

Additional dbSNP identifiers (rs#s) for CCDC34 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC34 Gene

Variant ID Type Subtype PubMed ID
nsv467782 CNV gain 19166990
nsv553914 CNV gain 21841781

Variation tolerance for CCDC34 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC34 Gene

Disorders for CCDC34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC34 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CCD34_HUMAN
  • Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2). {ECO:0000269 PubMed:11173847}.
genes like me logo Genes that share disorders with CCDC34: view

No data available for Genatlas for CCDC34 Gene

Publications for CCDC34 Gene

  1. Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K … Gal A (Cytogenetics and cell genetics 2000) 2 3 4
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4
  3. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Overexpression of Coiled-Coil Domain-Containing Protein 34 (CCDC34) and its Correlation with Angiogenesis in Esophageal Squamous Cell Carcinoma. (PMID: 29397026) Hu DD … Hu B (Medical science monitor : international medical journal of experimental and clinical research 2018) 3

Products for CCDC34 Gene

Sources for CCDC34 Gene