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CCDC34 Gene(Protein Coding)

Coiled-Coil Domain Containing 34

GCID:
GC11M027327
GIFtS:
38
Genes Participants
UDN Logo

Aliases for CCDC34 Gene

Aliases for CCDC34 Gene

  • Coiled-Coil Domain Containing 34 2 3 5
  • Renal Carcinoma Antigen NY-REN-41 3 4
  • RAMA3 3 4
  • Coiled-Coil Domain-Containing Protein 34 3
  • NY-REN-41 Antigen 3
  • NY-REN-41 3
  • L15 3

External Ids for CCDC34 Gene

Previous GeneCards Identifiers for CCDC34 Gene

  • GC11M027057

Summaries for CCDC34 Gene

GeneCards Summary for CCDC34 Gene

CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene.

Additional gene information for CCDC34 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC34 Gene

Genomics for CCDC34 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CCDC34 Gene

Promoters and enhancers for CCDC34 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I027360 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +1.5 1526 3.6 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF213 E2F8 ZNF143 DEK CCDC34 LOC105376671 GC11P027360
GH11I027211 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6 +148.1 148126 8 PKNOX1 INSM2 KLF17 FEZF1 ZBTB40 RAD21 RFX5 ZNF366 FOS DEK BBOX1-AS1 CCDC34 LIN7C LOC105376600 GC11P027127
GH11I027290 Enhancer 1 Ensembl ENCODE 4.3 +69.5 69526 6.8 FOXA2 ZNF529 ZNF133 ZNF2 ZBTB7B RAD21 YY1 RFX5 CBX5 ZNF143 LOC105376601 LOC105376671 BBOX1-AS1 CCDC34 BDNF
GH11I027279 Enhancer 0.9 Ensembl ENCODE 4.4 +82.2 82211 3.8 MAX EBF1 BATF ZNF644 RAD21 RARA YY1 FOSL2 FOS NR2F6 BBOX1-AS1 CCDC34 LOC105376601
GH11I027227 Enhancer 0.7 ENCODE dbSUPER 5.2 +134.7 134658 3.2 ZNF10 SCRT2 ATF2 TRIM28 BBOX1-AS1 CCDC34 LIN7C LOC105376600 LOC105376601
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC34 gene promoter:

Genomic Locations for CCDC34 Gene

Genomic Locations for CCDC34 Gene
chr11:27,330,827-27,363,868
(GRCh38/hg38)
Size:
33,042 bases
Orientation:
Minus strand
chr11:27,352,374-27,385,415
(GRCh37/hg19)

Genomic View for CCDC34 Gene

Genes around CCDC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC34 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC34 Gene

Proteins for CCDC34 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HJ3-CCD34_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 34
    Protein Accession:
    Q96HJ3
    Secondary Accessions:
    • B2R8G2
    • Q8IX69
    • Q9H2A6
    • Q9Y599

    Protein attributes for CCDC34 Gene

    Size:
    373 amino acids
    Molecular mass:
    43225 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
    SequenceCaution:
    • Sequence=AAD42874.1; Type=Frameshift; Positions=9, 21; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Positions=142, 243; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC34 Gene

Protein Expression for CCDC34 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC34 Gene

Domains & Families for CCDC34 Gene

Gene Families for CCDC34 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CCDC34 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC34: view

No data available for UniProtKB/Swiss-Prot for CCDC34 Gene

Function for CCDC34 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for CCDC34 Gene

genes like me logo Genes that share phenotypes with CCDC34: view

Animal Model Products

CRISPR Products

miRNA for CCDC34 Gene

miRTarBase miRNAs that target CCDC34

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC34 Gene

Localization for CCDC34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC34 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene

Pathways & Interactions for CCDC34 Gene

SuperPathways for CCDC34 Gene

PathCards logo More details on SuperPathways for CCDC34
No Data Available

Gene Ontology (GO) - Biological Process for CCDC34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC34 Gene

Drugs & Compounds for CCDC34 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCDC34 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCDC34 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC34 Gene

Coiled-coil domain containing 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC34 Gene

No ASD Table

Relevant External Links for CCDC34 Gene

GeneLoc Exon Structure for
CCDC34
ECgene alternative splicing isoforms for
CCDC34

Expression for CCDC34 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC34 Gene

mRNA expression in normal human tissues for CCDC34 Gene
mRNA expression by BioGPS for CCDC34 GenemRNA expression by GTEx for CCDC34 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene

This gene is overexpressed in Testis (x6.8).

Protein differential expression in normal tissues from HIPED for CCDC34 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC34 Gene



Protein tissue co-expression partners for CCDC34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC34 Gene:

CCDC34

SOURCE GeneReport for Unigene cluster for CCDC34 Gene:

Hs.143733
genes like me logo Genes that share expression patterns with CCDC34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC34 Gene

Orthologs for CCDC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC34 33 34
  • 99.55 (n)
cow
(Bos Taurus)
 Mammalia CCDC34 33 34
  • 86.94 (n)
dog
(Canis familiaris)
 Mammalia CCDC34 33 34
  • 84.4 (n)
mouse
(Mus musculus)
 Mammalia Ccdc34 33 16 34
  • 80.04 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc34 33
  • 79.13 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CCDC34 34
  • 65 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CCDC34 34
  • 42 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCDC34 33 34
  • 67.19 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia ccdc34 33
  • 57.2 (n)
zebrafish
(Danio rerio)
 Actinopterygii CCDC34 34
  • 28 (a)
 OneToOne
Species where no ortholog for CCDC34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC34 Gene

ENSEMBL:
Gene Tree for CCDC34 (if available)
TreeFam:
Gene Tree for CCDC34 (if available)

Paralogs for CCDC34 Gene

Pseudogenes.org Pseudogenes for CCDC34 Gene

genes like me logo Genes that share paralogs with CCDC34: view

No data available for Paralogs for CCDC34 Gene

Variants for CCDC34 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CCDC34 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000147449 -- 27,344,176(-) AAAAAAA/AAAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000159123 -- 27,341,332(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000276507 -- 27,341,063(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000439990 -- 27,343,597(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000497902 -- 27,339,593(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC34 Gene

Variant ID Type Subtype PubMed ID
nsv467782 CNV gain 19166990
nsv553914 CNV gain 21841781

Variation tolerance for CCDC34 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC34 Gene

Disorders for CCDC34 Gene

UniProtKB/Swiss-Prot

CCD34_HUMAN
  • Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2). {ECO:0000269 PubMed:11173847}.

Additional Disease Information for CCDC34

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC34 Gene.

No data available for MalaCards and Genatlas for CCDC34 Gene

Publications for CCDC34 Gene

  1. Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K … Gal A (Cytogenetics and cell genetics 2000) 2 3 4 58
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58
  3. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CCDC34 Gene

Sources for CCDC34 Gene

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