Aliases for CCDC34 Gene
Aliases for CCDC34 Gene
External Ids for CCDC34 Gene
- HGNC: 25079
- Entrez Gene: 91057
- Ensembl: ENSG00000109881
- OMIM: 612324
- UniProtKB: Q96HJ3
Previous GeneCards Identifiers for CCDC34 Gene
- GC11M027057
Summaries for CCDC34 Gene
GeneCards Summary for CCDC34 Gene
CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene.
Additional gene information for CCDC34 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC34 Gene
Genomics for CCDC34 Gene
GeneHancer (GH) Regulatory Elements for CCDC34 Gene
Promoters and enhancers for CCDC34 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J027360 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE | 650.7 | +1.5 | 1526 | 3.6 | MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF213 E2F8 ZNF143 DEK | CCDC34 LOC105376671 GC11P027360 | |
| GH11J027211 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 6 | +148.1 | 148126 | 8 | PKNOX1 INSM2 KLF17 FEZF1 ZBTB40 RAD21 RFX5 ZNF366 FOS DEK | BBOX1-AS1 CCDC34 LIN7C LOC105376600 GC11P027127 | |
| GH11J027290 | Enhancer | 1 | Ensembl ENCODE | 4.3 | +69.5 | 69526 | 6.8 | FOXA2 ZNF133 ZNF2 ZBTB7B RAD21 RFX5 YY1 CBX5 ZNF143 ZNF654 | LOC105376601 BBOX1-AS1 CCDC34 BDNF | |
| GH11J027279 | Enhancer | 0.9 | Ensembl ENCODE | 4.4 | +82.2 | 82211 | 3.8 | MAX EBF1 BATF ZNF644 RAD21 RBPJ RARA YY1 IKZF5 FOSL2 | BBOX1-AS1 CCDC34 LOC105376601 | |
| GH11J027227 | Enhancer | 0.7 | ENCODE dbSUPER | 5.2 | +134.7 | 134658 | 3.2 | ZNF10 SCRT2 ATF2 TRIM28 | BBOX1-AS1 CCDC34 LIN7C LOC105376600 LOC105376601 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCDC34 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCDC34 gene promoter:
-
- oct-B3
- GATA-1
- GATA-2
- GATA-3
- Oct-B1
- oct-B2
- POU2F2C
- POU2F1
- POU2F1a
- POU2F2
Regulatory Element Products
Genomic Locations for CCDC34 Gene
Genomic Locations for CCDC34 Gene
- chr11:27,330,827-27,363,868
- (GRCh38/hg38)
- Size:
- 33,042 bases
- Orientation:
- Minus strand
- chr11:27,352,374-27,385,415
- (GRCh37/hg19)
- Size:
- 33,042 bases
- Orientation:
- Minus strand
Genomic View for CCDC34 Gene
Genes around CCDC34 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p14.1 by Entrez Gene
- 11p14.1 by HGNC
- 11p14.1 by Ensembl
CCDC34 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC34 Gene
Proteins for CCDC34 Gene
-
Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96HJ3-CCD34_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 34
- Protein Accession:
- Q96HJ3
- B2R8G2
- Q8IX69
- Q9H2A6
- Q9Y599
Protein attributes for CCDC34 Gene
- Size:
- 373 amino acids
- Molecular mass:
- 43225 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
- SequenceCaution:
-
- Sequence=AAD42874.1; Type=Frameshift; Positions=9, 21; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Positions=142, 243; Evidence={ECO:0000305};
Protein Expression for CCDC34 Gene
Post-translational modifications for CCDC34 Gene
Other Protein References for CCDC34 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCDC34
- Invitrogen Antibodies for CCDC34 (AFLGC-CCDC34)
- Search GeneTex for Antibodies for CCDC34
-
Boster Bio Antibodies for CCDC34
Protein Products
-
OriGene Purified Proteins for CCDC34
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC34
- Origene Custom Protein Services for CCDC34
- Search GeneTex for Proteins for CCDC34
Assay Products
No data available for DME Specific Peptides for CCDC34 Gene
Domains & Families for CCDC34 Gene
Gene Families for CCDC34 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for CCDC34 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC34 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CCDC34 Gene
Function for CCDC34 Gene
Phenotypes From GWAS Catalog for CCDC34 Gene
Phenotypes for CCDC34 Gene
- GenomeRNAi human phenotypes for CCDC34:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC34
-
CRISPR Products
-
OriGene CRISPR knockouts for CCDC34
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC34
- genomics-online: gRNA clones - Search results for available CCDC34 gene related products
- Applied Biological Materials CRISPR for CCDC34
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC34
- GenScript: Design CRISPR guide RNA sequences for CCDC34
miRNA for CCDC34 Gene
- miRTarBase miRNAs that target CCDC34
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC34
- Browse OriGene Inhibitory RNA Products For CCDC34
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34
- genomics-online: shRNA clones - Search results for available CCDC34 gene related products
Clone Products
-
OriGene ORF clones in human for CCDC34
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Custom all cDNA clones Services for CCDC34
- Sino Biological Human cDNA Clone for CCDC34
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC34
- genomics-online: cdna clones - Search results for available CCDC34 gene related products
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- Applied Biological Materials Clones for CCDC34
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCDC34
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC34 Gene
Localization for CCDC34 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
- Nuclear membrane (2)
- Nucleoli fibrillar center (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene
Pathways & Interactions for CCDC34 Gene
No Data Available
Interacting Proteins for CCDC34 Gene
GPS-Prot Interaction Network for CCDC34
No data available for Pathways by source and SIGNOR curated interactions for CCDC34 Gene
Transcripts for CCDC34 Gene
mRNA/cDNA for CCDC34 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (152) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000529615 716 bps (uc057zya.1)
- ENST00000328697 2103 bps (uc001mrh.2)
- ENST00000317945 2109 bps (uc001mri.2)
Unigene Clusters for CCDC34 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC34
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC34
- genomics-online: gRNA clones - Search results for available CCDC34 gene related products
- Applied Biological Materials CRISPR for CCDC34
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC34
- GenScript: Design CRISPR guide RNA sequences for CCDC34
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC34
- Browse OriGene Inhibitory RNA Products For CCDC34
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC34
- genomics-online: shRNA clones - Search results for available CCDC34 gene related products
Clone Products
-
OriGene ORF clones in human for CCDC34
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Custom all cDNA clones Services for CCDC34
- Sino Biological Human cDNA Clone for CCDC34
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC34
- genomics-online: cdna clones - Search results for available CCDC34 gene related products
- orf clones - Search results for available CCDC34 gene related products
- Applied Biological Materials Clones for CCDC34
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CCDC34 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene
This gene is overexpressed in Testis (x6.8).
This gene is overexpressed in Plasma (67.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC34 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCDC34 Gene:
CCDC34SOURCE GeneReport for Unigene cluster for CCDC34 Gene:
Hs.143733Primer Products
-
OriGene qPCR primer pairs for CCDC34
-
OriGene qPCR primer pairs and template standards for CCDC34
- genomics-online: primer clones - Search results for available CCDC34 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC34 Gene
Orthologs for CCDC34 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC34 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCDC34 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCDC34 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ccdc34 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccdc34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC34 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CCDC34 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCDC34 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc34 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CCDC34 34 |
|
OneToOne |
- Species where no ortholog for CCDC34 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CCDC34 Gene
- ENSEMBL:
- Gene Tree for CCDC34 (if available)
- TreeFam:
- Gene Tree for CCDC34 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCDC34: view image
Paralogs for CCDC34 Gene
Pseudogenes.org Pseudogenes for CCDC34 Gene
No data available for Paralogs for CCDC34 Gene
Variants for CCDC34 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000147449 | -- | 27,344,176(-) | AAAAAAA/AAAAAAAA | genic_downstream_transcript_variant, intron_variant | |
| rs1000159123 | -- | 27,341,332(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000276507 | -- | 27,341,063(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000439990 | -- | 27,343,597(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000497902 | -- | 27,339,593(-) | T/C | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.87;
87.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCDC34 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC34
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC34 Gene
Disorders for CCDC34 Gene
UniProtKB/Swiss-Prot
CCD34_HUMAN- Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2). {ECO:0000269 PubMed:11173847}.
Additional Disease Information for CCDC34
No disorders were found for CCDC34 Gene.
No data available for MalaCards and Genatlas for CCDC34 Gene
Publications for CCDC34 Gene
- Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K … Gal A (Cytogenetics and cell genetics 2000) 2 3 4 58
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58
- Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
Products for CCDC34 Gene
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- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for CCDC34
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- OriGene qPCR primer pairs for CCDC34
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- Browse Antibodies
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- Invitrogen Antibodies for CCDC34 (AFLGC-CCDC34)
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- antibodies-online: Search results for available CCDC34 related products ranked by validation data
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- genomics-online: shRNA clones - Search results for available CCDC34 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC34
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- Boster Bio Antibodies for CCDC34
- Browse Boster Bio ELISA Kits
Sources for CCDC34 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt