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Aliases for CCDC33 Gene

Aliases for CCDC33 Gene

  • Coiled-Coil Domain Containing 33 2 3 5
  • Cancer/Testis Antigen 61 2 3 4
  • CT61 3 4
  • Coiled-Coil Domain-Containing Protein 33 3
  • Hypothetical Protein HP11097 3
  • HP11097 3

External Ids for CCDC33 Gene

Previous GeneCards Identifiers for CCDC33 Gene

  • GC15P072347
  • GC15P072316
  • GC15P074509
  • GC15P051324

Summaries for CCDC33 Gene

GeneCards Summary for CCDC33 Gene

CCDC33 (Coiled-Coil Domain Containing 33) is a Protein Coding gene.

Additional gene information for CCDC33 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC33 Gene

Genomics for CCDC33 Gene

GeneHancer (GH) Regulatory Elements for CCDC33 Gene

Promoters and enhancers for CCDC33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074199 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552.2 -0.7 -662 5.3 SIN3A FEZF1 ZNF2 GLIS2 ZNF143 ZNF548 FOS DEK SP3 JUNB CCDC33 STRA6 PML ISLR2 ISLR ENSG00000261543
GH15I074316 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 560.9 +115.8 115839 4.3 HDGF GLIS2 ZNF143 KLF7 RUNX3 YY2 NFYC REST ZSCAN16 GLIS1 CCDC33 ENSG00000277749 PML ISLR LOC101929333 CLK3 UBL7-AS1 STRA6 SCAMP2 CSK
GH15I074236 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 550.3 +33.5 33533 0.2 RFX1 MAX MYC LOC105370893 CCDC33 STRA6 ISLR PIR42753
GH15I074168 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -30.9 -30947 7.3 ZNF473 ZSCAN4 GLI4 ZNF48 ZNF2 SCRT2 EGR2 ZIK1 ZNF398 ZNF645 ISLR EDC3 FAM219B STRA6 ENSG00000261543 CCDC33 ISLR2 SCAMP5 UBL7 CD276
GH15I074239 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 +37.4 37405 1.9 HDGF YY1 GLIS2 ZNF143 FOS SP3 RXRA REST SREBF1 ZNF610 ISLR CCDC33 STRA6 LOC283731 ISLR2 RPP25 LOC105370893 PIR42753
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC33 gene promoter:

Genomic Locations for CCDC33 Gene

Genomic Locations for CCDC33 Gene
133,768 bases
Plus strand

Genomic View for CCDC33 Gene

Genes around CCDC33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC33 Gene

Proteins for CCDC33 Gene

  • Protein details for CCDC33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 33
    Protein Accession:
    Secondary Accessions:
    • A8K3U4
    • A8MPQ6
    • A8MV61
    • A8MVU9
    • B3KQ49
    • Q8TAX6
    • Q9H5Q6

    Protein attributes for CCDC33 Gene

    958 amino acids
    Molecular mass:
    107216 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC33 Gene


neXtProt entry for CCDC33 Gene

Post-translational modifications for CCDC33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC33 Gene

Domains & Families for CCDC33 Gene

Gene Families for CCDC33 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CCDC33 Gene


Suggested Antigen Peptide Sequences for CCDC33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC33: view

No data available for UniProtKB/Swiss-Prot for CCDC33 Gene

Function for CCDC33 Gene

Phenotypes From GWAS Catalog for CCDC33 Gene

Gene Ontology (GO) - Molecular Function for CCDC33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC33: view
genes like me logo Genes that share phenotypes with CCDC33: view

Animal Models for CCDC33 Gene

MGI Knock Outs for CCDC33:

Animal Model Products

miRNA for CCDC33 Gene

miRTarBase miRNAs that target CCDC33

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC33 Gene

Localization for CCDC33 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC33 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC33 Gene

Pathways & Interactions for CCDC33 Gene

SuperPathways for CCDC33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC33 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC33 Gene

Drugs & Compounds for CCDC33 Gene

No Compound Related Data Available

Transcripts for CCDC33 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC33 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19
SP1: - - - - -
SP3: -
SP4: -

Relevant External Links for CCDC33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC33 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC33 Gene

This gene is overexpressed in Testis (x25.8), Fallopian Tube (x6.7), and Cervix - Endocervix (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC33 Gene

This gene is overexpressed in Lymph node (18.1), Spleen (7.9), and Colon (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC33 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC33 Gene:


SOURCE GeneReport for Unigene cluster for CCDC33 Gene:

genes like me logo Genes that share expression patterns with CCDC33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC33 Gene

Orthologs for CCDC33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608474 33
  • 95.34 (n)
CCDC33 34
  • 64 (a)
(Bos Taurus)
Mammalia CCDC33 33 34
  • 84.22 (n)
(Canis familiaris)
Mammalia CCDC33 33 34
  • 84.07 (n)
(Rattus norvegicus)
Mammalia Ccdc33 33
  • 78.96 (n)
(Mus musculus)
Mammalia Ccdc33 33 16 34
  • 78.55 (n)
(Ornithorhynchus anatinus)
Mammalia CCDC33 34
  • 45 (a)
(Monodelphis domestica)
Mammalia CCDC33 34
  • 40 (a)
(Gallus gallus)
Aves CCDC33 34
  • 23 (a)
(Danio rerio)
Actinopterygii ccdc33 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for CCDC33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC33 Gene

Gene Tree for CCDC33 (if available)
Gene Tree for CCDC33 (if available)

Paralogs for CCDC33 Gene

No data available for Paralogs for CCDC33 Gene

Variants for CCDC33 Gene

Sequence variations from dbSNP and Humsavar for CCDC33 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs111489755 uncertain-significance, Syndromic Microphthalmia, Recessive 74,202,177(+) C/G/T upstream_transcript_variant
rs267607096 pathogenic, Microphthalmia syndromic 9 74,202,199(+) C/T upstream_transcript_variant
rs606231126 pathogenic, Microphthalmia syndromic 9 74,202,216(+) AGT/GG upstream_transcript_variant
rs763026708 uncertain-significance, Syndromic Microphthalmia, Recessive 74,202,264(+) A/G upstream_transcript_variant
rs773460079 uncertain-significance, Syndromic Microphthalmia, Recessive 74,202,797(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC33 Gene

Variant ID Type Subtype PubMed ID
esv2666153 CNV deletion 23128226
esv2674756 CNV deletion 23128226
esv275019 CNV loss 21479260
esv3636902 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv1608 CNV insertion 18451855
nsv1609 CNV insertion 18451855
nsv471253 CNV loss 18288195
nsv473435 CNV novel sequence insertion 20440878
nsv510938 OTHER complex 20534489
nsv833053 CNV loss 17160897
nsv833054 CNV loss 17160897

Variation tolerance for CCDC33 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.38; 95.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC33 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC33 Gene

Disorders for CCDC33 Gene

Additional Disease Information for CCDC33

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC33 Gene

Publications for CCDC33 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CCDC33 Gene

Sources for CCDC33 Gene

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