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Aliases for CCDC25 Gene

Aliases for CCDC25 Gene

  • Coiled-Coil Domain Containing 25 2 3 5
  • Coiled-Coil Domain-Containing Protein 25 3 4

External Ids for CCDC25 Gene

Previous GeneCards Identifiers for CCDC25 Gene

  • GC08M027648
  • GC08M027590
  • GC08M026136

Summaries for CCDC25 Gene

GeneCards Summary for CCDC25 Gene

CCDC25 (Coiled-Coil Domain Containing 25) is a Protein Coding gene. Diseases associated with CCDC25 include Phocomelia and Sc Phocomelia Syndrome.

Gene Wiki entry for CCDC25 Gene

Additional gene information for CCDC25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC25 Gene

Genomics for CCDC25 Gene

GeneHancer (GH) Regulatory Elements for CCDC25 Gene

Promoters and enhancers for CCDC25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J027771 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 622.4 -0.8 -846 4.6 ZNF652 ZFX SP1 ELF3 MNT SIX5 NKRF POLR2A MLLT1 GTF2F1 CCDC25 ESCO2 RNU6-1276P GC08P027774 CLU ELP3 SCARA3
GH08J027835 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 15.7 -64.7 -64722 3.2 MTA3 SP1 ZFX CC2D1A NKRF MLLT1 CEBPG RERE ZNF384 ZNF687 ENSG00000253176 PBK LOC100130612 CCDC25 ESCO2 RNU6-1276P
GH08J027729 Enhancer 1.1 Ensembl ENCODE dbSUPER 33.7 +43.1 43054 2.4 CBFA2T2 ZNF148 TRIM24 EGR1 SMARCA4 EZH2 TCF12 NCOR1 NFIC ZNF395 CCDC25 CLU RNU6-1276P ESCO2 SCARA3 ENSG00000253875 MIR3622B
GH08J027386 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +383.5 383525 6 ZNF687 MAFK RELA IKZF1 IKZF2 LARP7 SMAD5 SCRT2 RUNX3 ZNF112 CCDC25 EPHX2 PTK2B CHRNA2 ESCO2 RNU6-1276P MIR6842
GH08J027372 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +394.8 394814 9.9 SP1 NKRF ZNF687 RELA CREM MLLT1 IKZF1 CAVIN1 POLR2A IKZF2 PTK2B RNU6-1276P CCDC25 ESCO2 MIR6842
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC25 gene promoter:
  • AREB6
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • HNF-1
  • HNF-1A
  • NF-YA
  • TBP

Genomic Locations for CCDC25 Gene

Genomic Locations for CCDC25 Gene
chr8:27,733,316-27,772,655
(GRCh38/hg38)
Size:
39,340 bases
Orientation:
Minus strand
chr8:27,590,833-27,630,170
(GRCh37/hg19)
Size:
39,338 bases
Orientation:
Minus strand

Genomic View for CCDC25 Gene

Genes around CCDC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC25 Gene

Proteins for CCDC25 Gene

  • Protein details for CCDC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WR0-CCD25_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 25
    Protein Accession:
    Q86WR0
    Secondary Accessions:
    • Q0P663
    • Q96SI2
    • Q9NV98

    Protein attributes for CCDC25 Gene

    Size:
    208 amino acids
    Molecular mass:
    24479 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91857.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC25 Gene

Post-translational modifications for CCDC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC25 Gene

Domains & Families for CCDC25 Gene

Gene Families for CCDC25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC25 Gene

Suggested Antigen Peptide Sequences for CCDC25 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78914, moderately similar to Coiled-coil domain-containing protein 25 (B7Z2L8_HUMAN)
  • Coiled-coil domain-containing protein 25 (CCD25_HUMAN)
  • cDNA FLJ75148, highly similar to Homo sapiens coiled-coil domain containing 25 (CCDC25), transcript variant 2, mRNA (Q0P663_HUMAN)
  • CCDC25 protein (Q6PK69_HUMAN)
  • CCDC25 protein (Q7Z5U5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WR0

UniProtKB/Swiss-Prot:

CCD25_HUMAN :
  • Belongs to the CCDC25 family.
Family:
  • Belongs to the CCDC25 family.
genes like me logo Genes that share domains with CCDC25: view

Function for CCDC25 Gene

Phenotypes From GWAS Catalog for CCDC25 Gene

Gene Ontology (GO) - Molecular Function for CCDC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC25: view
genes like me logo Genes that share phenotypes with CCDC25: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC25 - Now 50% OFF >
  • * CCDC25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC25 Gene

Localization for CCDC25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC25 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC25 Gene

Pathways & Interactions for CCDC25 Gene

PathCards logo

SuperPathways for CCDC25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC25 Gene

Drugs & Compounds for CCDC25 Gene

No Compound Related Data Available

Transcripts for CCDC25 Gene

Unigene Clusters for CCDC25 Gene

Coiled-coil domain containing 25:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC25 - Now 50% OFF >
  • * CCDC25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC25 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13:

Relevant External Links for CCDC25 Gene

GeneLoc Exon Structure for
CCDC25
ECgene alternative splicing isoforms for
CCDC25

Expression for CCDC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC25 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.6) and Skin (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC25 Gene



Protein tissue co-expression partners for CCDC25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC25 Gene:

CCDC25

SOURCE GeneReport for Unigene cluster for CCDC25 Gene:

Hs.445512

Evidence on tissue expression from TISSUES for CCDC25 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with CCDC25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC25 Gene

Orthologs for CCDC25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC25 35 34
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC25 35 34
  • 93.27 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC25 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc25 17 35 34
  • 91.99 (n)
cow
(Bos Taurus)
Mammalia CCDC25 35 34
  • 91.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc25 34
  • 91.35 (n)
chicken
(Gallus gallus)
Aves CCDC25 35 34
  • 82.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC25 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc25 34
  • 77.99 (n)
Str.2958 34
African clawed frog
(Xenopus laevis)
Amphibia 2o545-prov 34
zebrafish
(Danio rerio)
Actinopterygii ccdc25 34 35
  • 76.33 (n)
zgc64173 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003621 34
  • 61.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4593 34 35
  • 58.94 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.2 34
  • 57 (n)
Y54G11A.2 35
  • 54 (a)
OneToMany
F43C1.7 35
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JLP2 35 37
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11500 34
  • 64.81 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6664 34
rice
(Oryza sativa)
Liliopsida Os01g0750500 34
  • 60.44 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.728 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6097 35
  • 65 (a)
OneToOne
Cin.11963 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06750 34
  • 55.44 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11963 34
Species where no ortholog for CCDC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC25 Gene

ENSEMBL:
Gene Tree for CCDC25 (if available)
TreeFam:
Gene Tree for CCDC25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC25: view image

Paralogs for CCDC25 Gene

Pseudogenes.org Pseudogenes for CCDC25 Gene

genes like me logo Genes that share paralogs with CCDC25: view

No data available for Paralogs for CCDC25 Gene

Variants for CCDC25 Gene

Sequence variations from dbSNP and Humsavar for CCDC25 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs111510470 likely-benign, Roberts-SC phocomelia syndrome 27,774,556(-) T/G upstream_transcript_variant
rs541613867 uncertain-significance, Roberts-SC phocomelia syndrome 27,774,586(-) C/G upstream_transcript_variant
rs886062855 uncertain-significance, Roberts-SC phocomelia syndrome 27,774,580(-) G/A upstream_transcript_variant
rs886062856 uncertain-significance, Roberts-SC phocomelia syndrome 27,774,591(-) C/T upstream_transcript_variant
rs886062857 uncertain-significance, Roberts-SC phocomelia syndrome 27,774,622(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC25 Gene

Variant ID Type Subtype PubMed ID
esv3616726 CNV loss 21293372
nsv1017032 CNV loss 25217958
nsv397387 CNV deletion 16902084
nsv507451 OTHER sequence alteration 20534489
nsv528584 CNV gain 19592680
nsv610867 CNV gain 21841781
nsv981922 CNV duplication 23825009

Variation tolerance for CCDC25 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC25 Gene

Disorders for CCDC25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCDC25 Gene - From: GeneCards

Disorder Aliases PubMed IDs
phocomelia
sc phocomelia syndrome
  • sc pseudothalidomide syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCDC25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC25 Gene

Publications for CCDC25 Gene

  1. High expression of CCDC25 in cholangiocarcinoma tissue samples. (PMID: 28789463) Proungvitaya S … Wongkham S (Oncology letters 2017) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CCDC25 Gene

  • Biorbyt antibodies for CCDC25

Sources for CCDC25 Gene

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