Aliases for CCDC24 Gene

Aliases for CCDC24 Gene

  • Coiled-Coil Domain Containing 24 2 3 5
  • Coiled-Coil Domain-Containing Protein 24 3 4
  • MGC45441 2
  • CCDC24 5

External Ids for CCDC24 Gene

Previous GeneCards Identifiers for CCDC24 Gene

  • GC01P044127
  • GC01P044229
  • GC01P044457
  • GC01P042572

Summaries for CCDC24 Gene

GeneCards Summary for CCDC24 Gene

CCDC24 (Coiled-Coil Domain Containing 24) is a Protein Coding gene. Diseases associated with CCDC24 include Congenital Stationary Night Blindness.

Additional gene information for CCDC24 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC24 Gene

Genomics for CCDC24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC24

Top Transcription factor binding sites by QIAGEN in the CCDC24 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • ER-alpha
  • NF-1
  • Oct-B1

Genomic Locations for CCDC24 Gene

Genomic Locations for CCDC24 Gene
chr1:43,991,359-43,996,528
(GRCh38/hg38)
Size:
5,170 bases
Orientation:
Plus strand
chr1:44,457,031-44,462,200
(GRCh37/hg19)
Size:
5,170 bases
Orientation:
Plus strand

Genomic View for CCDC24 Gene

Genes around CCDC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC24 Gene

Proteins for CCDC24 Gene

  • Protein details for CCDC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L8-CCD24_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 24
    Protein Accession:
    Q8N4L8
    Secondary Accessions:
    • Q6RWT2

    Protein attributes for CCDC24 Gene

    Size:
    307 amino acids
    Molecular mass:
    34322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC24 Gene

Post-translational modifications for CCDC24 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCDC24 Gene

Domains & Families for CCDC24 Gene

Gene Families for CCDC24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC24 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 24 (CCD24_HUMAN)
  • Coiled-coil domain containing 24, isoform CRA_b (Q05BG8_HUMAN)
genes like me logo Genes that share domains with CCDC24: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC24 Gene

Function for CCDC24 Gene

Phenotypes From GWAS Catalog for CCDC24 Gene

Gene Ontology (GO) - Molecular Function for CCDC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC24: view
genes like me logo Genes that share phenotypes with CCDC24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC24 Gene

Localization for CCDC24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC24 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC24 Gene

Pathways & Interactions for CCDC24 Gene

PathCards logo

SuperPathways for CCDC24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001835 blastocyst hatching IEA --
genes like me logo Genes that share ontologies with CCDC24: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC24 Gene

Drugs & Compounds for CCDC24 Gene

No Compound Related Data Available

Transcripts for CCDC24 Gene

mRNA/cDNA for CCDC24 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC24

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC24 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8:
SP9:
SP10: - - -
SP11: - - - - - -
SP12: - - - - - - -

Relevant External Links for CCDC24 Gene

GeneLoc Exon Structure for
CCDC24

Expression for CCDC24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC24 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC24 Gene

This gene is overexpressed in Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC24 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC24 Gene



Protein tissue co-expression partners for CCDC24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC24

SOURCE GeneReport for Unigene cluster for CCDC24 Gene:

Hs.632394

Evidence on tissue expression from TISSUES for CCDC24 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with CCDC24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC24 Gene

Orthologs for CCDC24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC24 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC24 30 31
  • 83.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc24 30
  • 79.53 (n)
Dog
(Canis familiaris)
Mammalia CCDC24 30
  • 77.86 (n)
Mouse
(Mus musculus)
Mammalia Ccdc24 31
  • 59 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC24 31
  • 50 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC24 31
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC24 31
  • 30 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc24 30
  • 54.02 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc24 30 31
  • 47.07 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToOne
Species where no ortholog for CCDC24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC24 Gene

ENSEMBL:
Gene Tree for CCDC24 (if available)
TreeFam:
Gene Tree for CCDC24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC24: view image

Paralogs for CCDC24 Gene

No data available for Paralogs for CCDC24 Gene

Variants for CCDC24 Gene

Additional dbSNP identifiers (rs#s) for CCDC24 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC24 Gene

Variant ID Type Subtype PubMed ID
nsv546142 CNV loss 21841781
nsv732 CNV insertion 18451855

Variation tolerance for CCDC24 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC24 Gene

Disorders for CCDC24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CCDC24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC24 Gene

Publications for CCDC24 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. (PMID: 29892012) Chen S … Yu H (Nature genetics 2018) 3

Products for CCDC24 Gene

Sources for CCDC24 Gene