Aliases for CCDC198 Gene

Aliases for CCDC198 Gene

  • Coiled-Coil Domain Containing 198 2 3 5
  • Uncharacterized Protein CCDC198 3 4
  • C14orf105 3 4
  • Chromosome 14 Open Reading Frame 105 2
  • Uncharacterized Protein C14orf105 3
  • FLJ10650 2
  • CCDC198 5

External Ids for CCDC198 Gene

Previous HGNC Symbols for CCDC198 Gene

  • C14orf105

Summaries for CCDC198 Gene

GeneCards Summary for CCDC198 Gene

CCDC198 (Coiled-Coil Domain Containing 198) is a Protein Coding gene.

Additional gene information for CCDC198 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC198 Gene

Genomics for CCDC198 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC198 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J057491 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +0.3 297 4.3 REST ZNF629 SP1 ZNF501 CEBPA POLR2A SCRT2 ZBTB44 SP2 ZNF639 CCDC198 LOC112268129 NAA30
GH14J057461 Enhancer 0.6 Ensembl ENCODE 11.3 +31.8 31795 1.4 CEBPB FOS JUND RF00017-1567 CCDC198 lnc-SLC35F4-1 NAA30
GH14J057463 Enhancer 0.4 Ensembl ENCODE 11.1 +29.9 29853 0.9 HNF1A CCDC198 RF00017-1567 lnc-SLC35F4-1 NAA30
GH14J057412 Enhancer 0.5 Ensembl 10.2 +81.6 81580 0.4 ZNF629 ATF7 ATF2 PRDM6 PKNOX1 NAA30 CCDC198 lnc-NAA30-3
GH14J057486 Enhancer 0.5 FANTOM5 5.8 +7.0 7027 0.4 CTCF RAD21 TRIM22 SCRT2 SMC3 ZNF654 ZNF660 ZNF24 NAA30 CCDC198 LOC112268129 lnc-SLC35F4-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC198 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC198

Genomic Locations for CCDC198 Gene

Genomic Locations for CCDC198 Gene
chr14:57,469,300-57,493,981
(GRCh38/hg38)
Size:
24,682 bases
Orientation:
Minus strand
chr14:57,936,019-57,960,585
(GRCh37/hg19)
Size:
24,567 bases
Orientation:
Minus strand

Genomic View for CCDC198 Gene

Genes around CCDC198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC198 Gene

Proteins for CCDC198 Gene

  • Protein details for CCDC198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVL8-CC198_HUMAN
    Recommended name:
    Uncharacterized protein CCDC198
    Protein Accession:
    Q9NVL8
    Secondary Accessions:
    • Q17R99
    • Q53G04

    Protein attributes for CCDC198 Gene

    Size:
    296 amino acids
    Molecular mass:
    34690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC198 Gene

Post-translational modifications for CCDC198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC198 Gene

Domains & Families for CCDC198 Gene

Gene Families for CCDC198 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC198 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC198 Gene

GenScript: Design optimal peptide antigens:
  • C14orf105 protein (B7ZL43_HUMAN)
  • Chromosome 14 open reading frame 105, isoform CRA_b (Q17R99_HUMAN)
genes like me logo Genes that share domains with CCDC198: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC198 Gene

Function for CCDC198 Gene

Gene Ontology (GO) - Molecular Function for CCDC198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC198: view
genes like me logo Genes that share phenotypes with CCDC198: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC198

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC198 Gene

Localization for CCDC198 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC198 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC198 Gene

Pathways & Interactions for CCDC198 Gene

PathCards logo

SuperPathways for CCDC198 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC198 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC198 Gene

Drugs & Compounds for CCDC198 Gene

No Compound Related Data Available

Transcripts for CCDC198 Gene

mRNA/cDNA for CCDC198 Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC198

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC198 Gene

No ASD Table

Relevant External Links for CCDC198 Gene

GeneLoc Exon Structure for
CCDC198

Expression for CCDC198 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC198

Evidence on tissue expression from TISSUES for CCDC198 Gene

  • Liver(5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CCDC198: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC198 Gene

Orthologs for CCDC198 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC198 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C14H14orf105 30
  • 99.32 (n)
C14orf105 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C8H14orf105 30
  • 86.23 (n)
C14orf105 31
  • 69 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C10H14orf105 30
  • 85.94 (n)
C14orf105 31
  • 67 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 1700011H14Rik 30 31
  • 78.31 (n)
OneToOne
ccdc198 17
Rat
(Rattus norvegicus)
Mammalia LOC102556129 30
  • 78.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia C14orf105 31
  • 45 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C14orf105 31
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C5H14ORF105 30
  • 53.91 (n)
C14orf105 31
  • 32 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496610 30
  • 53.66 (n)
Species where no ortholog for CCDC198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCDC198 Gene

ENSEMBL:
Gene Tree for CCDC198 (if available)
TreeFam:
Gene Tree for CCDC198 (if available)

Paralogs for CCDC198 Gene

No data available for Paralogs for CCDC198 Gene

Variants for CCDC198 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC198 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs34960436 Benign: not specified 57,480,703(-) G/A NONSENSE
rs1152530 - p.Tyr235Cys

Additional dbSNP identifiers (rs#s) for CCDC198 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC198 Gene

Variant ID Type Subtype PubMed ID
nsv1046422 CNV gain 25217958
nsv1053638 CNV loss 25217958
nsv832806 CNV loss 17160897

Variation tolerance for CCDC198 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC198 Gene

Human Gene Mutation Database (HGMD)
CCDC198
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC198

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC198 Gene

Disorders for CCDC198 Gene

No disorders were found for CCDC198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC198 Gene

Publications for CCDC198 Gene

  1. Human sperm proteins identified by 2-dimensional electrophoresis and mass spectrometry and their relevance to a transcriptomic analysis. (PMID: 29526398) Nowicka-Bauer K … Kurpisz M (Reproductive biology 2018) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. (PMID: 29348145) Fung E … D'Angiolella V (EMBO reports 2018) 3
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for CCDC198 Gene

Sources for CCDC198 Gene