Aliases for CCDC186 Gene

Aliases for CCDC186 Gene

  • Coiled-Coil Domain Containing 186 2 3 5
  • Coiled-Coil Domain-Containing Protein 186 3 4
  • CTCL Tumor Antigen HD-CL-01/L14-2 3 4
  • C10orf118 3 4
  • Golgin104 2 3
  • CCCP-1 2 3
  • Chromosome 10 Open Reading Frame 118 2
  • CTCL Tumor Antigen L14-2 3
  • FLJ10188 2
  • FLJ35301 2
  • CCDC186 5

External Ids for CCDC186 Gene

Previous HGNC Symbols for CCDC186 Gene

  • C10orf118

Summaries for CCDC186 Gene

GeneCards Summary for CCDC186 Gene

CCDC186 (Coiled-Coil Domain Containing 186) is a Protein Coding gene.

Gene Wiki entry for CCDC186 Gene

Additional gene information for CCDC186 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC186 Gene

Genomics for CCDC186 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC186 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J114171 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 554 3.8 SP1 CREB1 PRDM10 ZNF629 ZNF692 POLR2A BACH1 TARDBP ZHX2 FOXA1 TDRD1 CCDC186 MIR2110 VWA2 ENSG00000273904 ADRB1
GH10J114645 Enhancer 1.3 Ensembl ENCODE dbSUPER 33.1 -476.1 -476067 11.4 ZNF221 GATAD2A PRDM10 REST ZNF629 ZNF692 JUND FOXA1 PRDM1 CTCF FAM160B1 CCDC186 NHLRC2 SNODB803 lnc-AFAP1L2-5 ABLIM1 AFAP1L2
GH10J113851 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.7 +320.2 320154 6.6 PRDM10 ZNF629 REST TFE3 ZNF692 POLR2A ZNF174 BACH1 ZHX2 PRDM1 DCLRE1A NHLRC2 lnc-NRAP-4 CCDC186 TCF7L2 LOC107984271 MN309123 PLEKHS1
GH10J114042 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.8 +128.7 128713 6.1 PRDM10 KDM1A ZNF692 POLR2A FOXA1 PATZ1 EZH2 ZNF600 ZNF341 EED ADRB1 lnc-CCDC186-1 lnc-ADRB1-3 CCDC186 lnc-ADRB1-1
GH10J115051 Enhancer 0.7 Ensembl ENCODE 10 -876.2 -876246 2.2 TEAD4 ZNF740 USF1 TEAD1 RAD21 ZNF354B NR4A1 NR2C1 ZNF639 CTCF CCDC186 ATRNL1 piR-49399-001 piR-50443-052 LOC107984272 TRUB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC186 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC186

Genomic Locations for CCDC186 Gene

Genomic Locations for CCDC186 Gene
chr10:114,120,862-114,174,255
(GRCh38/hg38)
Size:
53,394 bases
Orientation:
Minus strand
chr10:115,880,621-115,934,364
(GRCh37/hg19)
Size:
53,744 bases
Orientation:
Minus strand

Genomic View for CCDC186 Gene

Genes around CCDC186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC186 Gene

Proteins for CCDC186 Gene

  • Protein details for CCDC186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E2-CC186_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 186
    Protein Accession:
    Q7Z3E2
    Secondary Accessions:
    • Q2M2V6
    • Q3ZB81
    • Q6NS91
    • Q7RTP1
    • Q8N117
    • Q8N3G3
    • Q8N6C2
    • Q9NWA3

    Protein attributes for CCDC186 Gene

    Size:
    898 amino acids
    Molecular mass:
    103687 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 212.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792.; Evidence={ECO:0000305}; Sequence=BAA91480.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for CCDC186 Gene

Post-translational modifications for CCDC186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC186 Gene

Domains & Families for CCDC186 Gene

Gene Families for CCDC186 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC186 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC186 Gene

GenScript: Design optimal peptide antigens:
  • C10orf118 protein (A0PJB6_HUMAN)
  • CTCL tumor antigen HD-CL-01/L14-2 (CJ118_HUMAN)
  • C10orf118 protein (Q3B7W4_HUMAN)
  • C10orf118 protein (Q496Y1_HUMAN)
  • C10orf118 protein (Q8WW61_HUMAN)
genes like me logo Genes that share domains with CCDC186: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC186 Gene

Function for CCDC186 Gene

Phenotypes From GWAS Catalog for CCDC186 Gene

genes like me logo Genes that share phenotypes with CCDC186: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC186

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC186 Gene

Localization for CCDC186 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC186 gene
Compartment Confidence
golgi apparatus 4
nucleus 3
cytoskeleton 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CCDC186: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC186 Gene

Pathways & Interactions for CCDC186 Gene

PathCards logo

SuperPathways for CCDC186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009617 response to bacterium IEA --
GO:0035773 insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0042593 glucose homeostasis IEA --
GO:0099518 vesicle cytoskeletal trafficking IEA --
genes like me logo Genes that share ontologies with CCDC186: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC186 Gene

Drugs & Compounds for CCDC186 Gene

No Compound Related Data Available

Transcripts for CCDC186 Gene

mRNA/cDNA for CCDC186 Gene

3 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC186

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC186 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 17c · 17d ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CCDC186 Gene

GeneLoc Exon Structure for
CCDC186

Expression for CCDC186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC186 Gene

Protein differential expression in normal tissues from HIPED for CCDC186 Gene

This gene is overexpressed in Frontal cortex (25.4), Plasma (15.0), and Bone (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC186 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC186

Evidence on tissue expression from TISSUES for CCDC186 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with CCDC186: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC186 Gene

Orthologs for CCDC186 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC186 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C10H10orf118 30
  • 99.7 (n)
C10orf118 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C10orf118 31
  • 95 (a)
OneToOne
C28H10orf118 30
  • 91.82 (n)
Cow
(Bos Taurus)
Mammalia C26H10orf118 30
  • 92.09 (n)
C10orf118 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia A630007B06Rik 30 31
  • 83.89 (n)
OneToOne
Ccdc186 17
Oppossum
(Monodelphis domestica)
Mammalia C10orf118 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C10orf118 31
  • 81 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1307158 30
  • 80.47 (n)
Chicken
(Gallus gallus)
Aves C6H10ORF118 30
  • 73.86 (n)
C10orf118 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C10orf118 31
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c10orf118 30
  • 68.16 (n)
Str.10253 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16139 30
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-225b10.4 30
  • 66.98 (n)
C12H10orf118 31
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG4925 30 31
  • 45.05 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cccp-1 30 31
  • 45.38 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12155 30
Species where no ortholog for CCDC186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCDC186 Gene

ENSEMBL:
Gene Tree for CCDC186 (if available)
TreeFam:
Gene Tree for CCDC186 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC186: view image

Paralogs for CCDC186 Gene

No data available for Paralogs for CCDC186 Gene

Variants for CCDC186 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC186 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
715023 Benign: not provided 114,135,957(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
732655 Benign: not provided 114,144,515(-) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1061159 - p.Thr85Ile
rs12782946 - p.Arg179Gln
rs7095762 - p.Gln271Lys

Additional dbSNP identifiers (rs#s) for CCDC186 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC186 Gene

Variant ID Type Subtype PubMed ID
dgv287e212 CNV loss 25503493
dgv288e212 CNV loss 25503493
esv2560217 CNV deletion 19546169
esv2741151 CNV deletion 23290073
nsv1045020 CNV loss 25217958
nsv1052267 CNV loss 25217958
nsv7211 OTHER inversion 18451855

Variation tolerance for CCDC186 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.26; 81.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC186 Gene

Human Gene Mutation Database (HGMD)
CCDC186
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC186 Gene

Disorders for CCDC186 Gene

No disorders were found for CCDC186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC186 Gene

Publications for CCDC186 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S … Williams SC (BMC genomics 2003) 2 3 4
  2. Toward a comprehensive map of the effectors of rab GTPases. (PMID: 25453831) Gillingham AK … Munro S (Developmental cell 2014) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PMID: 14996095) Hartmann TB … Eichmüller S (The British journal of dermatology 2004) 3 4

Products for CCDC186 Gene

Sources for CCDC186 Gene