Aliases for CCDC185 Gene
Aliases for CCDC185 Gene
External Ids for CCDC185 Gene
- HGNC: 26654
- Entrez Gene: 164127
- Ensembl: ENSG00000178395
- UniProtKB: Q8N715
Previous HGNC Symbols for CCDC185 Gene
- C1orf65
Summaries for CCDC185 Gene
GeneCards Summary for CCDC185 Gene
CCDC185 (Coiled-Coil Domain Containing 185) is a Protein Coding gene.
Additional gene information for CCDC185 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC185 Gene
Genomics for CCDC185 Gene
GeneHancer (GH) Regulatory Elements for CCDC185 Gene
Promoters and enhancers for CCDC185 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J223402 | Enhancer | 0.9 | ENCODE | 0.4 | +9.2 | 9244 | 1.1 | ATF1 KLF14 RFX5 ZNF766 ZNF366 ZNF350 FOS ATF7 CREM SMARCA5 | NVL CICP5 CICP13 CCDC185 LOC105373034 | |
| GH01J223411 | Enhancer | 0.3 | ENCODE | 0.4 | +18.2 | 18156 | 1 | FOS | SUSD4 CCDC185 LOC105373034 | |
| GH01J223401 | Enhancer | 0.2 | Ensembl | 0.4 | +7.9 | 7928 | 0.2 | SUSD4 CCDC185 LOC105373034 | ||
| GH01J223499 | Enhancer | 0.8 | Ensembl ENCODE | 0.1 | +107.3 | 107340 | 1.8 | ZNF263 RFX1 SALL2 ZNF398 MNT NFXL1 ZIC2 OSR2 ZFHX2 JUND | NVL CICP5 TAF1A ENSG00000272750 LOC100287497 HHIPL2 LOC105373034 CCDC185 | |
| GH01J223504 | Enhancer | 0.6 | ENCODE | 0.1 | +111.5 | 111538 | 1.1 | ZMYM3 ZBTB8A ZNF670 GABPA OSR2 ZFHX2 EGR1 GLIS1 ZNF629 FOS | LOC105373034 ENSG00000229399 CCDC185 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCDC185 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CCDC185 Gene
Genomic Locations for CCDC185 Gene
- chr1:223,393,373-223,395,470
- (GRCh38/hg38)
- Size:
- 2,098 bases
- Orientation:
- Plus strand
- chr1:223,566,715-223,568,812
- (GRCh37/hg19)
Genomic View for CCDC185 Gene
Genes around CCDC185 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by Entrez Gene
- 1q41 by HGNC
- 1q41 by Ensembl
CCDC185 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC185 Gene
Proteins for CCDC185 Gene
-
Protein details for CCDC185 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N715-CC185_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 185
- Protein Accession:
- Q8N715
- Q8N746
- Q8NA93
Protein attributes for CCDC185 Gene
- Size:
- 623 amino acids
- Molecular mass:
- 72349 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCDC185 Gene
Post-translational modifications for CCDC185 Gene
Other Protein References for CCDC185 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC185
- Novus Biologicals Antibodies for CCDC185
- Invitrogen Antibodies for CCDC185
- GeneTex CCDC185 Antibody for CCDC185
Protein Products
-
OriGene Purified Proteins for CCDC185
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC185
- Origene Custom Protein Services for CCDC185
- Novus Biologicals lysates for CCDC185
- Search GeneTex for Proteins for CCDC185
Assay Products
No data available for DME Specific Peptides for CCDC185 Gene
Domains & Families for CCDC185 Gene
Gene Families for CCDC185 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC185 Gene
Function for CCDC185 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for CCDC185 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC185
-
CRISPR Products
-
OriGene CRISPR knockouts for CCDC185
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC185
- genomics-online: gRNA clones - Search results for available C1orf65 gene related products
- Applied Biological Materials CRISPR for CCDC185
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC185
- GenScript: Design CRISPR guide RNA sequences for CCDC185
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC185
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC185
- genomics-online: shRNA clones - Search results for available C1orf65 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CCDC185
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC185
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC185
- genomics-online: cdna clones - Search results for available C1orf65 gene related products
- orf clones - Search results for available C1orf65 gene related products
- Applied Biological Materials Clones for CCDC185
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCDC185
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC185 Gene
Localization for CCDC185 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC185 Gene
Transcripts for CCDC185 Gene
mRNA/cDNA for CCDC185 Gene
- (11) Selected AceView cDNA sequences:
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000366875 2054 bps (uc001hoa.3)
CRISPR Products
-
OriGene CRISPR knockouts for CCDC185
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC185
- genomics-online: gRNA clones - Search results for available C1orf65 gene related products
- Applied Biological Materials CRISPR for CCDC185
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC185
- GenScript: Design CRISPR guide RNA sequences for CCDC185
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC185
- Browse OriGene Inhibitory RNA Products For CCDC185
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC185
- genomics-online: shRNA clones - Search results for available C1orf65 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CCDC185
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC185
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC185
- genomics-online: cdna clones - Search results for available C1orf65 gene related products
- orf clones - Search results for available C1orf65 gene related products
- Applied Biological Materials Clones for CCDC185
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CCDC185 Gene
This gene is overexpressed in Frontal cortex (29.7), Fetal gut (15.9), and Tlymphocyte (11.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC185 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC185 Gene:
CCDC185Primer Products
-
OriGene qPCR primer pairs for CCDC185
- genomics-online: primer clones - Search results for available C1orf65 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC185 Gene
Orthologs for CCDC185 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C1H1orf65 33 |
|
||
| C1orf65 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C16H1orf65 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC289334 33 |
|
||
| mouse (Mus musculus) |
Mammalia | 4922505E12Rik 34 33 |
|
OneToOne | |
| Ccdc185 16 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | C1orf65 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | C1orf65 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C1orf65 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C1orf65 34 |
|
OneToOne |
- Species where no ortholog for CCDC185 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CCDC185 Gene
- ENSEMBL:
- Gene Tree for CCDC185 (if available)
- TreeFam:
- Gene Tree for CCDC185 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCDC185: view image
Paralogs for CCDC185 Gene
No data available for Paralogs for CCDC185 Gene
Variants for CCDC185 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000906000 | -- | 223,392,969(+) | G/A/T | upstream_transcript_variant | |
| rs1001191183 | -- | 223,393,151(+) | C/G | upstream_transcript_variant | |
| rs1001205476 | -- | 223,393,372(+) | C/A/G | upstream_transcript_variant | |
| rs1001276943 | -- | 223,395,741(+) | T/C | downstream_transcript_variant | |
| rs1002063153 | -- | 223,392,198(+) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.64;
72.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCDC185 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC185
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC185 Gene
Disorders for CCDC185 Gene
Additional Disease Information for CCDC185
No disorders were found for CCDC185 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC185 Gene
Publications for CCDC185 Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for CCDC185 Gene
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- Custom Antibody ServicesOriGene Antibodies for CCDC185
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- Custom Assay Services
- OriGene Purified Proteins for CCDC185
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- OriGene qPCR primer pairs for CCDC185
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- Novus Biologicals Antibodies for CCDC185
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- Browse Antibodies
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- VectorBuilder custom plasmid, inducible vectors for CCDC185
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC185
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- GeneTex CCDC185 Antibody for CCDC185
- Search GeneTex for Proteins for CCDC185
- Horizon Cell Lines for CCDC185
- genomics-online: cdna clones - Search results for available C1orf65 gene related products
- orf clones - Search results for available C1orf65 gene related products
- genomics-online: gRNA clones - Search results for available C1orf65 gene related products
- genomics-online: primer clones - Search results for available C1orf65 gene related products
- genomics-online: shRNA clones - Search results for available C1orf65 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC185
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC185
- GeneCopoeia miRNA 3'UTR Target clone products for CCDC185
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC185
Sources for CCDC185 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio