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Aliases for CCDC18 Gene

Aliases for CCDC18 Gene

  • Coiled-Coil Domain Containing 18 2 3 5
  • Sarcoma Antigen NY-SAR-24 3 4
  • Coiled-Coil Domain-Containing Protein 18 3
  • Sarcoma Antigen NY-SAR-41 3
  • NY-SAR-41 3

External Ids for CCDC18 Gene

Previous GeneCards Identifiers for CCDC18 Gene

  • GC01P093359
  • GC01P093418
  • GC01P093645
  • GC01P091767

Summaries for CCDC18 Gene

GeneCards Summary for CCDC18 Gene

CCDC18 (Coiled-Coil Domain Containing 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleotide binding.

Additional gene information for CCDC18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC18 Gene

Genomics for CCDC18 Gene

GeneHancer (GH) Regulatory Elements for CCDC18 Gene

Promoters and enhancers for CCDC18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J093177 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.5 +0.1 56 4.8 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 ZNF263 SP3 CCDC18 GC01M093180 TMED5 CCDC18-AS1 SNORA66 SNORD21 RPL5 DNTTIP2 ENSG00000230439 MTF2
GH01J092482 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -695.0 -695034 5.3 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF213 ZNF207 ZNF143 KLF13 SP3 GFI1 FAM69A CCDC18-AS1 SNORA66 MTF2 SNORD21 EVI5 GLMN RPL5 CCDC18
GH01J093078 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 10.9 -99.5 -99484 4.5 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 MTF2 CCDC18-AS1 SNORA66 SNORD21 RPL5 TRR-TCT1-1 GLMN DR1 RPAP2 DNTTIP2
GH01J093344 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +167.6 167624 5.9 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CCDC18-AS1 DR1 TMED5 SNORD21 SNORA66 MTF2 RPL5 DNTTIP2 CCDC18 EVI5
GH01J093446 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 9.3 +268.9 268901 4.4 SMAD1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF213 ZNF143 ZNF263 SP3 FNBP1L CCDC18-AS1 MTF2 SNORA66 CCDC18 RNA5SP53 GC01M093489
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC18 gene promoter:
  • RFX1
  • HSF2
  • deltaCREB
  • CREB
  • IRF-1
  • STAT1
  • MEF-2A
  • aMEF-2
  • Zic3
  • c-Myb

Genomic Locations for CCDC18 Gene

Genomic Locations for CCDC18 Gene
chr1:93,179,919-93,279,037
(GRCh38/hg38)
Size:
99,119 bases
Orientation:
Plus strand
chr1:93,645,476-93,744,287
(GRCh37/hg19)
Size:
98,812 bases
Orientation:
Plus strand

Genomic View for CCDC18 Gene

Genes around CCDC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC18 Gene

Proteins for CCDC18 Gene

  • Protein details for CCDC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9S5-CCD18_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 18
    Protein Accession:
    Q5T9S5
    Secondary Accessions:
    • Q6ZU17

    Protein attributes for CCDC18 Gene

    Size:
    1454 amino acids
    Molecular mass:
    168962 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86410.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC18 Gene

Post-translational modifications for CCDC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC18 Gene

Domains & Families for CCDC18 Gene

Gene Families for CCDC18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC18 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC18: view

No data available for UniProtKB/Swiss-Prot for CCDC18 Gene

Function for CCDC18 Gene

Phenotypes From GWAS Catalog for CCDC18 Gene

genes like me logo Genes that share phenotypes with CCDC18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC18

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC18 Gene

Localization for CCDC18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC18 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC18 Gene

Pathways & Interactions for CCDC18 Gene

SuperPathways for CCDC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC18 Gene

Drugs & Compounds for CCDC18 Gene

No Compound Related Data Available

Transcripts for CCDC18 Gene

Unigene Clusters for CCDC18 Gene

Coiled-coil domain containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC18

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC18 Gene

No ASD Table

Relevant External Links for CCDC18 Gene

GeneLoc Exon Structure for
CCDC18
ECgene alternative splicing isoforms for
CCDC18

Expression for CCDC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC18 Gene

This gene is overexpressed in Testis (x4.5).

Protein differential expression in normal tissues from HIPED for CCDC18 Gene

This gene is overexpressed in Brain (20.8), Plasma (20.4), and Bone marrow mesenchymal stem cell (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC18 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC18 Gene:

CCDC18

SOURCE GeneReport for Unigene cluster for CCDC18 Gene:

Hs.745125
genes like me logo Genes that share expression patterns with CCDC18: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC18 Gene

Orthologs for CCDC18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC18 34 33
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC18 34 33
  • 91.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC540863 33
  • 91.6 (n)
CCDC18 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc18 33
  • 87.13 (n)
mouse
(Mus musculus)
Mammalia Ccdc18 16 34 33
  • 86.73 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC18 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC18 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC18 34 33
  • 65.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC18 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc18 33
  • 56.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia sojo-A 33
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-1a11.3 33
  • 48.19 (n)
CCDC18 34
  • 33 (a)
OneToOne
Species where no ortholog for CCDC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC18 Gene

ENSEMBL:
Gene Tree for CCDC18 (if available)
TreeFam:
Gene Tree for CCDC18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC18: view image

Paralogs for CCDC18 Gene

(1) SIMAP similar genes for CCDC18 Gene using alignment to 11 proteins:

  • CCD18_HUMAN
  • E9PDA0_HUMAN
  • E9PFB9_HUMAN
  • F5H8K2_HUMAN
  • G3V388_HUMAN
  • H0YCD6_HUMAN
  • H0YDP2_HUMAN
  • H7C0C9_HUMAN
  • J3KP97_HUMAN
  • Q5T9S2_HUMAN
  • Q6PH87_HUMAN
genes like me logo Genes that share paralogs with CCDC18: view

No data available for Paralogs for CCDC18 Gene

Variants for CCDC18 Gene

Sequence variations from dbSNP and Humsavar for CCDC18 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000006426 -- 93,224,022(+) C/A intron_variant
rs1000027098 -- 93,212,537(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000038747 -- 93,212,873(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000054194 -- 93,262,740(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000210042 -- 93,228,044(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC18 Gene

Variant ID Type Subtype PubMed ID
esv3586825 CNV loss 21293372
esv3586826 CNV loss 21293372
nsv830614 CNV loss 17160897
nsv830625 CNV loss 17160897
nsv946080 CNV duplication 23825009
nsv946082 CNV duplication 23825009

Additional Variant Information for CCDC18 Gene

Human Gene Mutation Database (HGMD)
CCDC18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CCDC18 Gene

Disorders for CCDC18 Gene

Additional Disease Information for CCDC18

No disorders were found for CCDC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC18 Gene

Publications for CCDC18 Gene

  1. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee SY … Scanlan MJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CCDC18 Gene

  • Biorbyt antibodies for CCDC18

Sources for CCDC18 Gene

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