CCDC178 Gene (Protein Coding)

Coiled-Coil Domain Containing 178

GC18M032937
GIFtS:
29
See more...

Aliases for CCDC178 Gene

Aliases for CCDC178 Gene

  • Coiled-Coil Domain Containing 178 2 3 5
  • Coiled-Coil Domain-Containing Protein 178 3 4
  • C18orf34 3 4
  • Chromosome 18 Open Reading Frame 34 2
  • FLJ44050 2
  • CCDC178 5

External Ids for CCDC178 Gene

Previous HGNC Symbols for CCDC178 Gene

  • C18orf34

Previous GeneCards Identifiers for CCDC178 Gene

  • GC18M030518

Summaries for CCDC178 Gene

GeneCards Summary for CCDC178 Gene

CCDC178 (Coiled-Coil Domain Containing 178) is a Protein Coding gene.

Additional gene information for CCDC178 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC178 Gene

Genomics for CCDC178 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CCDC178 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J033440 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 270.5 +0.4 401 1.8 CTCF KLF9 ZNF585B ZFP37 NRF1 TAF1 EGR1 FOXM1 RAD21 L3MBTL2 CCDC178 lnc-NOL4-5 KLHL14
GH18J033183 Enhancer 1 UCNEbase Ensembl ENCODE 5 +256.8 256772 2.5 CTCF SPI1 RAD21 EP300 PRDM1 CCDC178 HSALNG0120809 lnc-KLHL14-2 KLHL14
GH18J033232 Enhancer 0.8 Ensembl ENCODE 5.5 +208.9 208900 0.8 NR2C1 CTCF REST TRIM22 SMC3 RAD21 HNF4A SCRT1 FOXM1 NR2F1 CCDC178 RF00017-2653 piR-61101-313 HSALNG0120809 KLHL14
GH18J033116 Enhancer 0.6 Ensembl ENCODE 5.5 +324.5 324500 1.2 FEZF1 SPI1 TRIM28 EP300 CCDC178 piR-58537-011 piR-57133-276 KLHL14
GH18J033144 Enhancer 0.5 FANTOM5 Ensembl 5.2 +295.1 295101 3.6 NFE2 piR-46662-301 piR-31162-217 piR-45471-276 piR-53431-306 piR-54764-295 piR-55650-301 CCDC178 piR-58537-011 lnc-KLHL14-1 KLHL14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC178 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC178

Genomic Locations for CCDC178 Gene

Latest Assembly
chr18:32,937,402-33,441,101
(GRCh38/hg38)
Size:
503,700 bases
Orientation:
Minus strand

Previous Assembly
chr18:30,517,370-31,021,004
(GRCh37/hg19 by Entrez Gene)
Size:
503,635 bases
Orientation:
Minus strand

chr18:30,517,366-31,021,065
(GRCh37/hg19 by Ensembl)
Size:
503,700 bases
Orientation:
Minus strand

Genomic View for CCDC178 Gene

Genes around CCDC178 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC178 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC178 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC178 Gene

Proteins for CCDC178 Gene

Products:

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  2. Protein products for research
  3. Assay products for research

  • Protein details for CCDC178 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJE1-CC178_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 178
    Protein Accession:
    Q5BJE1
    Secondary Accessions:
    • A6NDC6
    • J3KS92
    • Q6ZP67
    • Q6ZU20

    Protein attributes for CCDC178 Gene

    Size:
    867 amino acids
    Molecular mass:
    102011 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC178 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC178 Gene

Protein Expression for CCDC178 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC178 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC178 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC178 Gene

Domains & Families for CCDC178 Gene

Gene Families for CCDC178 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC178 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC178 Gene

GenScript: Design optimal peptide antigens:
  • C18orf34 protein (A1L4G8_HUMAN)
  • C18orf34 protein (B7ZM04_HUMAN)
  • C18orf34 protein (Q6P5S0_HUMAN)
genes like me logo Genes that share domains with CCDC178: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC178 Gene

Function for CCDC178 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for CCDC178 Gene

genes like me logo Genes that share phenotypes with CCDC178: view

Animal Models for CCDC178 Gene

MGI Knock Outs for CCDC178:
  • Ccdc178 Ccdc178<tm1b(EUCOMM)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC178

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC178 Gene

Localization for CCDC178 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC178 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC178 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036064 ciliary basal body IDA 29257953
genes like me logo Genes that share ontologies with CCDC178: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CCDC178 Gene

Pathways & Interactions for CCDC178 Gene

PathCards logo

SuperPathways for CCDC178 Gene

No Data Available

Interacting Proteins for CCDC178 Gene

Gene Ontology (GO) - Biological Process for CCDC178 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC178 Gene

Drugs & Compounds for CCDC178 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for CCDC178 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for CCDC178 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC178

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC178 Gene

No ASD Table

Relevant External Links for CCDC178 Gene

GeneLoc Exon Structure for
CCDC178

Expression for CCDC178 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC178 Gene

mRNA expression in normal human tissues for CCDC178 Gene
mRNA expression by BioGPS for CCDC178 GenemRNA expression by GTEx for CCDC178 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for CCDC178 Gene

This gene is overexpressed in Testis (x11.4) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC178 Gene

This gene is overexpressed in Heart (40.0) and Adipocyte (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC178 Gene



Protein tissue co-expression partners for CCDC178 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC178

SOURCE GeneReport for Unigene cluster for CCDC178 Gene:

Hs.115461

Evidence on tissue expression from TISSUES for CCDC178 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with CCDC178: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC178 Gene

Orthologs for CCDC178 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC178 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CCDC178 30 31
  • 99.12 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CCDC178 30 31
  • 82.05 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CCDC178 30 31
  • 77.6 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ccdc178 30 17 31
  • 66.05 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ccdc178 30
  • 65.19 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia CCDC178 31
  • 33 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CCDC178 31
  • 28 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CCDC178 31
  • 38 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CCDC178 31
  • 27 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii CCDC178 31
  • 19 (a)
 OneToOne
Species where no ortholog for CCDC178 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC178 Gene

ENSEMBL:
Gene Tree for CCDC178 (if available)
TreeFam:
Gene Tree for CCDC178 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC178: view image

Paralogs for CCDC178 Gene

(1) SIMAP similar genes for CCDC178 Gene using alignment to 6 proteins:

  • CC178_HUMAN
  • F8W7A7_HUMAN
  • J3KRT5_HUMAN
  • J3KSU3_HUMAN
  • J3QKU2_HUMAN
  • J3QRM8_HUMAN
genes like me logo Genes that share paralogs with CCDC178: view

No data available for Paralogs for CCDC178 Gene

Variants for CCDC178 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC178 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs12606658 - p.Ala42Thr
rs457896 - p.Leu600Arg
rs466113 - p.Asp601Asn
rs58448816 - p.Asp420Asn
rs9965081 - p.Val465Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC178 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC178 Gene

Variant ID Type Subtype PubMed ID
dgv3333n100 CNV loss 25217958
dgv5883n54 CNV loss 21841781
esv2453134 CNV deletion 19546169
esv2541909 CNV deletion 19546169
esv2593101 CNV deletion 19546169
esv2634635 CNV deletion 19546169
esv2660234 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2676754 CNV deletion 23128226
esv2678538 CNV deletion 23128226
esv2758720 CNV loss 17122850
esv2762000 CNV loss 21179565
esv3583002 CNV loss 25503493
esv3642162 CNV gain 21293372
esv3642164 CNV loss 21293372
esv3642165 CNV loss 21293372
esv3642166 CNV loss 21293372
esv3642167 CNV loss 21293372
esv3642169 CNV loss 21293372
esv3642170 CNV loss 21293372
esv3893088 CNV loss 25118596
nsv1063958 CNV loss 25217958
nsv1066607 CNV loss 25217958
nsv1127625 CNV deletion 24896259
nsv130684 CNV deletion 16902084
nsv131084 CNV deletion 16902084
nsv438279 CNV loss 16468122
nsv475651 CNV novel sequence insertion 20440878
nsv478874 CNV novel sequence insertion 20440878
nsv520131 CNV loss 19592680
nsv528397 CNV loss 19592680
nsv833617 CNV gain 17160897
nsv833618 CNV gain 17160897

Variation tolerance for CCDC178 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC178 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC178

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC178 Gene

Disorders for CCDC178 Gene

Additional Disease Information for CCDC178

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CCDC178 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC178 Gene

Publications for CCDC178 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. (PMID: 29257953) Sigg MA … Reiter JF (Developmental cell 2017) 3

ExternalLinks

View latest publications for CCDC178 gene in Mastermind

Products for CCDC178 Gene

Sources for CCDC178 Gene