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Aliases for CCDC177 Gene

Aliases for CCDC177 Gene

  • Coiled-Coil Domain Containing 177 2 3 5
  • Myelin Proteolipid Protein-Like Protein 2 3 4
  • C14orf162 3 4
  • PLPL 3 4
  • Coiled-Coil Domain-Containing Protein 177 3
  • Chromosome 14 Open Reading Frame 162 2

External Ids for CCDC177 Gene

Previous HGNC Symbols for CCDC177 Gene

  • C14orf162

Previous GeneCards Identifiers for CCDC177 Gene

  • GC14M070037

Summaries for CCDC177 Gene

GeneCards Summary for CCDC177 Gene

CCDC177 (Coiled-Coil Domain Containing 177) is a Protein Coding gene.

Additional gene information for CCDC177 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC177 Gene

Genomics for CCDC177 Gene

GeneHancer (GH) Regulatory Elements for CCDC177 Gene

Promoters and enhancers for CCDC177 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I069571 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +1.6 1634 3.6 NFIB ZNF2 ZNF48 RAD21 ZNF335 GLIS2 ZNF366 ZNF143 RUNX3 ZNF654 CCDC177 SRSF5 SUSD6 ERH SLC10A1 GC14M069570
GH14I069579 Enhancer 1.2 Ensembl ENCODE 0.4 -5.2 -5226 1.3 PKNOX1 ATF1 FOXA2 ARID4B ZNF2 ETS1 YY1 TCF12 ZNF766 ZNF143 SUSD6 SRSF5 SLC10A1 CCDC177 GC14P069585
GH14I069585 Enhancer 0.7 ENCODE 0.4 -10.3 -10296 0.2 CTCF KLF1 ZNF654 RB1 TRIM22 NCOA1 REST ZNF2 RAD21 TEAD3 GC14P069585 SRSF5 SUSD6 SLC10A1 CCDC177
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC177 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCDC177 Gene

Genomic Locations for CCDC177 Gene
chr14:69,569,814-69,574,883
(GRCh38/hg38)
Size:
5,070 bases
Orientation:
Minus strand
chr14:70,036,531-70,038,032
(GRCh37/hg19)

Genomic View for CCDC177 Gene

Genes around CCDC177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC177 Gene

Proteins for CCDC177 Gene

  • Protein details for CCDC177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQR7-CC177_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 177
    Protein Accession:
    Q9NQR7
    Secondary Accessions:
    • B2R5G1
    • Q2M359

    Protein attributes for CCDC177 Gene

    Size:
    707 amino acids
    Molecular mass:
    79739 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF86288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG35108.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CCDC177 Gene

Post-translational modifications for CCDC177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC177 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC177 Gene

Domains & Families for CCDC177 Gene

Gene Families for CCDC177 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC177 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC177: view

No data available for UniProtKB/Swiss-Prot for CCDC177 Gene

Function for CCDC177 Gene

Phenotypes for CCDC177 Gene

genes like me logo Genes that share phenotypes with CCDC177: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC177 Gene

Localization for CCDC177 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC177 Gene

Pathways & Interactions for CCDC177 Gene

SuperPathways for CCDC177 Gene

No Data Available

Interacting Proteins for CCDC177 Gene

Gene Ontology (GO) - Biological Process for CCDC177 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC177 Gene

Drugs & Compounds for CCDC177 Gene

No Compound Related Data Available

Transcripts for CCDC177 Gene

mRNA/cDNA for CCDC177 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC177 Gene

Coiled-coil domain containing 177:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC177 Gene

No ASD Table

Relevant External Links for CCDC177 Gene

GeneLoc Exon Structure for
CCDC177
ECgene alternative splicing isoforms for
CCDC177

Expression for CCDC177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC177 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC177 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.1), Brain - Cerebellum (x9.2), Brain - Cortex (x6.1), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of CCDC177 Gene:

CCDC177

SOURCE GeneReport for Unigene cluster for CCDC177 Gene:

Hs.458319
genes like me logo Genes that share expression patterns with CCDC177: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC177 Gene

Orthologs for CCDC177 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC177 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101057527 33
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToOne
CCDC177 33
  • 88.83 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
OneToOne
CCDC177 33
  • 88.02 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc177 33
  • 85 (n)
mouse
(Mus musculus)
Mammalia Ccdc177 33 16 34
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC177 33
  • 61.72 (n)
-- 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccdc177 33 34
  • 54.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3120 34
  • 17 (a)
OneToOne
Species where no ortholog for CCDC177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC177 Gene

ENSEMBL:
Gene Tree for CCDC177 (if available)
TreeFam:
Gene Tree for CCDC177 (if available)

Paralogs for CCDC177 Gene

No data available for Paralogs for CCDC177 Gene

Variants for CCDC177 Gene

Sequence variations from dbSNP and Humsavar for CCDC177 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000167449 -- 69,576,158(-) G/A upstream_transcript_variant
rs1000253961 -- 69,572,577(-) T/C coding_sequence_variant, missense_variant
rs1000285120 -- 69,572,419(-) G/A coding_sequence_variant, missense_variant
rs1000347949 -- 69,570,478(-) A/C 3_prime_UTR_variant
rs1000805579 -- 69,570,184(-) CCCCC/CCCCCC 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC177 Gene

Variant ID Type Subtype PubMed ID
dgv3743n54 CNV loss 21841781
dgv3744n54 CNV loss 21841781
esv25683 CNV loss 19812545
nsv1335 CNV deletion 18451855
nsv564970 CNV loss 21841781

Variation tolerance for CCDC177 Gene

Gene Damage Index Score: 2.65; 45.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC177

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC177 Gene

Disorders for CCDC177 Gene

Additional Disease Information for CCDC177

No disorders were found for CCDC177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC177 Gene

Publications for CCDC177 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. 2',3'-cyclic nucleotide 3'-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases. (PMID: 9143234) Rösener M … Martin R (Journal of neuroimmunology 1997) 22 58

Products for CCDC177 Gene

Sources for CCDC177 Gene

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