Aliases for CCDC175 Gene

Aliases for CCDC175 Gene

  • Coiled-Coil Domain Containing 175 2 3 5
  • Coiled-Coil Domain-Containing Protein 175 3 4
  • C14orf38 3 4
  • Chromosome 14 Open Reading Frame 38 2
  • C14_5395 3

External Ids for CCDC175 Gene

Previous HGNC Symbols for CCDC175 Gene

  • C14orf38

Previous GeneCards Identifiers for CCDC175 Gene

  • GC14M059971

Summaries for CCDC175 Gene

GeneCards Summary for CCDC175 Gene

CCDC175 (Coiled-Coil Domain Containing 175) is a Protein Coding gene.

Additional gene information for CCDC175 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC175 Gene

Genomics for CCDC175 Gene

GeneHancer (GH) Regulatory Elements for CCDC175 Gene

Promoters and enhancers for CCDC175 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J059582 Enhancer 0.3 ENCODE 507.3 -1.2 -1184 0.2 CTCF SPI1 CCDC175 lnc-RTN1-4
GH14J059870 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 8.4 -287.8 -287787 3 EP300 ZIC2 ZBTB26 SAP30 RFX1 CTBP1 ZNF341 EZH2 MYC ZBTB17 RTN1 PCNX4 CCDC175 lnc-LRRC9-3
GH14J059507 Enhancer 0.9 Ensembl ENCODE 13.1 +74.4 74428 1.2 CTCF REST RAD21 TRIM22 ZBTB26 SMC3 ESRRA MYNN CEBPG ZNF205 L3HYPDH CCDC175 JKAMP NONHSAG015131.2 piR-48553-110 ENSG00000258782
GH14J059575 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 7.3 +5.6 5562 1.6 ZNF217 CTCF ZIC2 ZBTB10 REST RFX1 RAD21 TRIM22 SMC3 CTBP1 KR153240-004 L3HYPDH RTN1 CCDC175 lnc-RTN1-2
GH14J059510 Enhancer 0.7 Ensembl ENCODE 13.1 +70.5 70452 2.4 CTCF ZIC2 SMC3 GATA3 ZNF654 ZNF2 RAD21 PRDM4 HLF ZNF143 piR-48553-110 L3HYPDH CCDC175 JKAMP NONHSAG015131.2 ENSG00000258782
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC175 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC175

Genomic Locations for CCDC175 Gene

Genomic Locations for CCDC175 Gene
chr14:59,504,539-59,582,114
(GRCh38/hg38)
Size:
77,576 bases
Orientation:
Minus strand
chr14:59,971,257-60,043,549
(GRCh37/hg19)
Size:
72,293 bases
Orientation:
Minus strand

Genomic View for CCDC175 Gene

Genes around CCDC175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC175 Gene

Proteins for CCDC175 Gene

  • Protein details for CCDC175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C221-CC175_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 175
    Protein Accession:
    P0C221
    Secondary Accessions:
    • G3V5J7

    Protein attributes for CCDC175 Gene

    Size:
    793 amino acids
    Molecular mass:
    93626 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC175 Gene

Post-translational modifications for CCDC175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC175 Gene

Domains & Families for CCDC175 Gene

Gene Families for CCDC175 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC175 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CCDC175: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC175 Gene

Function for CCDC175 Gene

Phenotypes From GWAS Catalog for CCDC175 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC175

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC175 Gene

Localization for CCDC175 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC175 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC175 Gene

Pathways & Interactions for CCDC175 Gene

PathCards logo

SuperPathways for CCDC175 Gene

No Data Available

Interacting Proteins for CCDC175 Gene

;

Gene Ontology (GO) - Biological Process for CCDC175 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC175 Gene

Drugs & Compounds for CCDC175 Gene

No Compound Related Data Available

Transcripts for CCDC175 Gene

mRNA/cDNA for CCDC175 Gene

1 REFSEQ mRNAs :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC175

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC175 Gene

No ASD Table

Relevant External Links for CCDC175 Gene

GeneLoc Exon Structure for
CCDC175

Expression for CCDC175 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC175 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC175 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.3) and Brain - Cerebellum (x10.8).

Protein differential expression in normal tissues from HIPED for CCDC175 Gene

This gene is overexpressed in Plasma (54.9) and CD8 Tcells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC175 Gene



Protein tissue co-expression partners for CCDC175 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC175

SOURCE GeneReport for Unigene cluster for CCDC175 Gene:

Hs.29706
genes like me logo Genes that share expression patterns with CCDC175: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC175 Gene

Orthologs for CCDC175 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC175 31 30
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC175 31 30
  • 77.9 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC175 31 30
  • 77.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc175 30
  • 68.01 (n)
mouse
(Mus musculus)
Mammalia Ccdc175 17 31 30
  • 66.97 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC175 31
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC175 31
  • 26 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC175 31
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccdc175 31
  • 20 (a)
OneToOne
Species where no ortholog for CCDC175 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC175 Gene

ENSEMBL:
Gene Tree for CCDC175 (if available)
TreeFam:
Gene Tree for CCDC175 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC175: view image

Paralogs for CCDC175 Gene

No data available for Paralogs for CCDC175 Gene

Variants for CCDC175 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC175 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs12887189 - p.Ser689Asn
rs17834244 - p.Gly164Arg
rs4261431 - p.Gly507Glu
rs4394993 - p.Ser689Arg

Additional dbSNP identifiers (rs#s) for CCDC175 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC175 Gene

Variant ID Type Subtype PubMed ID
esv2658502 CNV deletion 23128226
esv3353735 CNV insertion 20981092

Variation tolerance for CCDC175 Gene

Gene Damage Index Score: 5.07; 68.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC175 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC175

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC175 Gene

Disorders for CCDC175 Gene

Additional Disease Information for CCDC175

No disorders were found for CCDC175 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC175 Gene

Publications for CCDC175 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 54
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 54

Products for CCDC175 Gene

Sources for CCDC175 Gene