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Aliases for CCDC173 Gene

Aliases for CCDC173 Gene

  • Coiled-Coil Domain Containing 173 2 3 5
  • C2orf77 3 4
  • Coiled-Coil Domain-Containing Protein 173 3
  • Chromosome 2 Open Reading Frame 77 2
  • Hypothetical LOC129881 2

External Ids for CCDC173 Gene

Previous HGNC Symbols for CCDC173 Gene

  • C2orf77

Previous GeneCards Identifiers for CCDC173 Gene

  • GC02M170502

Summaries for CCDC173 Gene

GeneCards Summary for CCDC173 Gene

CCDC173 (Coiled-Coil Domain Containing 173) is a Protein Coding gene.

Additional gene information for CCDC173 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC173 Gene

Genomics for CCDC173 Gene

GeneHancer (GH) Regulatory Elements for CCDC173 Gene

Promoters and enhancers for CCDC173 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J169693 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 666.8 -0.4 -380 2.7 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 PHOSPHO2 CCDC173 PHOSPHO2-KLHL23 KLHL23 FASTKD1 PPIG SSB GC02P169728
GH02J169583 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.7 +109.3 109282 2.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D FASTKD1 PPIG GC02M169582 PHOSPHO2 CCDC173 SSB GC02P169639
GH02J169507 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.4 +183.5 183451 7.9 PKNOX1 FOXA2 FEZF1 FOS JUNB TSHZ1 MEF2D ATF4 MAFF SMARCA4 KLHL41 BBS5 PPIG CCDC173 PHOSPHO2 FASTKD1 KLHL23 GC02P169518 ENSG00000251569
GH02J169732 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.6 -39.5 -39515 2.1 ATF1 FOXA2 SIN3A ZNF48 NCOA2 GLIS2 ZNF143 ATF7 RUNX3 SP5 KLHL23 SSB CYB5AP2 CCDC173 PHOSPHO2 GC02M169725 GC02P169749 PHOSPHO2-KLHL23
GH02J169715 Enhancer 1.2 Ensembl ENCODE 15.2 -22.1 -22127 2.8 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 SP5 MXD4 ZNF592 FASTKD1 PHOSPHO2 CCDC173 ENSG00000229827 GC02P169728 PHOSPHO2-KLHL23 KLHL23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC173 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCDC173 Gene

Genomic Locations for CCDC173 Gene
49,009 bases
Minus strand
49,009 bases
Minus strand

Genomic View for CCDC173 Gene

Genes around CCDC173 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC173 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC173 Gene

Proteins for CCDC173 Gene

  • Protein details for CCDC173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 173
    Protein Accession:
    Secondary Accessions:
    • Q6PJF6

    Protein attributes for CCDC173 Gene

    552 amino acids
    Molecular mass:
    66403 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI17446.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CCDC173 Gene

Post-translational modifications for CCDC173 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC173 Gene

No data available for DME Specific Peptides for CCDC173 Gene

Domains & Families for CCDC173 Gene

Gene Families for CCDC173 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC173 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC173: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC173 Gene

Function for CCDC173 Gene

Phenotypes for CCDC173 Gene

genes like me logo Genes that share phenotypes with CCDC173: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC173

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC173 Gene

Localization for CCDC173 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC173 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC173 Gene

Pathways & Interactions for CCDC173 Gene

SuperPathways for CCDC173 Gene

No Data Available

Interacting Proteins for CCDC173 Gene

Gene Ontology (GO) - Biological Process for CCDC173 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC173 Gene

Drugs & Compounds for CCDC173 Gene

No Compound Related Data Available

Transcripts for CCDC173 Gene

mRNA/cDNA for CCDC173 Gene

Unigene Clusters for CCDC173 Gene

Coiled-coil domain containing 173:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC173

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC173 Gene

No ASD Table

Relevant External Links for CCDC173 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC173 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC173 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC173 Gene

This gene is overexpressed in Testis (x31.2).

Protein differential expression in normal tissues from HIPED for CCDC173 Gene

This gene is overexpressed in Blymphocyte (35.8) and Monocytes (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC173 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC173 Gene:


SOURCE GeneReport for Unigene cluster for CCDC173 Gene:

genes like me logo Genes that share expression patterns with CCDC173: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC173 Gene

Orthologs for CCDC173 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC173 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC173 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia CCDC173 34 33
  • 90.93 (n)
(Bos Taurus)
Mammalia CCDC173 34 33
  • 90.74 (n)
(Rattus norvegicus)
Mammalia Ccdc173 33
  • 82.78 (n)
(Mus musculus)
Mammalia Ccdc173 16 34 33
  • 81.32 (n)
(Monodelphis domestica)
Mammalia CCDC173 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC173 34
  • 54 (a)
(Gallus gallus)
Aves LOC101749600 33
  • 59.82 (n)
CCDC173 34
  • 43 (a)
(Anolis carolinensis)
Reptilia CCDC173 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc173 33
  • 54.22 (n)
(Danio rerio)
Actinopterygii ccdc173 34 33
  • 50.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for CCDC173 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC173 Gene

Gene Tree for CCDC173 (if available)
Gene Tree for CCDC173 (if available)
Evolutionary constrained regions (ECRs) for CCDC173: view image

Paralogs for CCDC173 Gene

No data available for Paralogs for CCDC173 Gene

Variants for CCDC173 Gene

Sequence variations from dbSNP and Humsavar for CCDC173 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001069 -- 169,675,537(-) C/T intron_variant
rs1000017178 -- 169,658,869(-) T/C intron_variant
rs1000067943 -- 169,658,599(-) A/G intron_variant
rs1000178995 -- 169,696,172(-) C/T upstream_transcript_variant
rs1000203248 -- 169,688,186(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC173 Gene

Variant ID Type Subtype PubMed ID
esv2721118 CNV deletion 23290073
esv3593327 CNV loss 21293372
nsv1007492 CNV gain 25217958
nsv1008726 CNV loss 25217958
nsv1011368 CNV loss 25217958
nsv834454 CNV loss 17160897

Variation tolerance for CCDC173 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC173 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC173 Gene

Disorders for CCDC173 Gene

Additional Disease Information for CCDC173

No disorders were found for CCDC173 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC173 Gene

Publications for CCDC173 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CCDC173 Gene

Sources for CCDC173 Gene

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