Aliases for CCDC17 Gene

Aliases for CCDC17 Gene

  • Coiled-Coil Domain Containing 17 2 3 5
  • Coiled-Coil Domain-Containing Protein 17 3 4
  • FLJ33084 2
  • CCDC17 5

External Ids for CCDC17 Gene

Previous GeneCards Identifiers for CCDC17 Gene

  • GC01M045755
  • GC01M045858
  • GC01M046086
  • GC01M044196

Summaries for CCDC17 Gene

GeneCards Summary for CCDC17 Gene

CCDC17 (Coiled-Coil Domain Containing 17) is a Protein Coding gene.

Additional gene information for CCDC17 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC17 Gene

Genomics for CCDC17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J045623 Promoter/Enhancer 0.7 EPDnew ENCODE 600.7 +0.9 897 0.5 RBM22 POLR2A REST CCDC17 lnc-GPBP1L1-2 NASP
GH01J045628 Promoter 0.4 EPDnew 600.7 -3.5 -3493 0.1 RBM22 CCDC17 lnc-CCDC17-1 GPBP1L1
GH01J045624 Enhancer 0.4 Ensembl 600.7 +0.3 287 0.2 POLR2A RBM22 NFIC NFIB CCDC17 lnc-GPBP1L1-2 MAST2 NASP
GH01J045630 Promoter 0.3 EPDnew 600.4 -5.7 -5748 0.1 CCDC17 GPBP1L1 TMEM69 MAST2 HMGB1P48 PRDX1 lnc-CCDC17-1
GH01J045625 Enhancer 0.2 Ensembl 600.7 -0.3 -314 0.2 CCDC17 PRDX1 IPP lnc-CCDC17-1 GPBP1L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC17

Top Transcription factor binding sites by QIAGEN in the CCDC17 gene promoter:
  • FAC1
  • Nkx2-5
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4

Genomic Locations for CCDC17 Gene

Genomic Locations for CCDC17 Gene
chr1:45,620,044-45,624,787
(GRCh38/hg38)
Size:
4,744 bases
Orientation:
Minus strand
chr1:46,085,716-46,089,731
(GRCh37/hg19)
Size:
4,016 bases
Orientation:
Minus strand

Genomic View for CCDC17 Gene

Genes around CCDC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC17 Gene

Proteins for CCDC17 Gene

  • Protein details for CCDC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LX7-CCD17_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 17
    Protein Accession:
    Q96LX7
    Secondary Accessions:
    • A1A4Y7
    • B4DNX7
    • B4E1Q5
    • C9J8L2
    • Q0P683
    • Q5T629

    Protein attributes for CCDC17 Gene

    Size:
    622 amino acids
    Molecular mass:
    67721 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71539.1; Type=Miscellaneous discrepancy; Note=Incompletely spliced mRNA.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CCDC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC17 Gene

Post-translational modifications for CCDC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC17 Gene

Domains & Families for CCDC17 Gene

Gene Families for CCDC17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC17 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 17 (CCD17_HUMAN)
genes like me logo Genes that share domains with CCDC17: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC17 Gene

Function for CCDC17 Gene

Phenotypes From GWAS Catalog for CCDC17 Gene

Gene Ontology (GO) - Molecular Function for CCDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC17: view
genes like me logo Genes that share phenotypes with CCDC17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC17 Gene

Localization for CCDC17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC17 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC17 Gene

Pathways & Interactions for CCDC17 Gene

PathCards logo

SuperPathways for CCDC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC17 Gene

Drugs & Compounds for CCDC17 Gene

No Compound Related Data Available

Transcripts for CCDC17 Gene

mRNA/cDNA for CCDC17 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC17

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for CCDC17 Gene

GeneLoc Exon Structure for
CCDC17

Expression for CCDC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lung (Respiratory System)

mRNA differential expression in normal tissues according to GTEx for CCDC17 Gene

This gene is overexpressed in Fallopian Tube (x11.5), Cervix - Endocervix (x6.2), Whole Blood (x4.5), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC17 Gene

This gene is overexpressed in Nasal epithelium (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC17 Gene



Protein tissue co-expression partners for CCDC17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC17

SOURCE GeneReport for Unigene cluster for CCDC17 Gene:

Hs.18912
genes like me logo Genes that share expression patterns with CCDC17: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC17 Gene

Orthologs for CCDC17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC17 30 31
  • 99.14 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC17 30 31
  • 80.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC17 30 31
  • 78.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc17 30 17 31
  • 71.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc17 30
  • 71.51 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCDC17 31
  • 47 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC17 31
  • 42 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC17 31
  • 42 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CR854855.2 31
  • 27 (a)
OneToOne
Species where no ortholog for CCDC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC17 Gene

ENSEMBL:
Gene Tree for CCDC17 (if available)
TreeFam:
Gene Tree for CCDC17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC17: view image

Paralogs for CCDC17 Gene

No data available for Paralogs for CCDC17 Gene

Variants for CCDC17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC17 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17410855 - p.Val470Ile
rs2297654 - p.Ile557Val
rs3014242 - p.Pro353Leu
rs3014246 - p.Ser580Asn

Additional dbSNP identifiers (rs#s) for CCDC17 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC17 Gene

Variant ID Type Subtype PubMed ID
esv3585911 CNV gain 21293372
esv3893512 CNV gain 25118596
nsv822509 CNV loss 20364138
nsv829726 CNV loss 17160897

Variation tolerance for CCDC17 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC17 Gene

Disorders for CCDC17 Gene

No disorders were found for CCDC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC17 Gene

Publications for CCDC17 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3

Products for CCDC17 Gene

Sources for CCDC17 Gene