Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC17 Gene

Aliases for CCDC17 Gene

  • Coiled-Coil Domain Containing 17 2 3 5
  • Coiled-Coil Domain-Containing Protein 17 3

External Ids for CCDC17 Gene

Previous GeneCards Identifiers for CCDC17 Gene

  • GC01M045755
  • GC01M045858
  • GC01M046086
  • GC01M044196

Summaries for CCDC17 Gene

GeneCards Summary for CCDC17 Gene

CCDC17 (Coiled-Coil Domain Containing 17) is a Protein Coding gene.

Additional gene information for CCDC17 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC17 Gene

Genomics for CCDC17 Gene

GeneHancer (GH) Regulatory Elements for CCDC17 Gene

Promoters and enhancers for CCDC17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J045623 Promoter/Enhancer 0.9 EPDnew ENCODE 650.7 +0.9 897 0.5 POLR2A REST CCDC17 ENSG00000281825
GH01J045628 Promoter 0.5 EPDnew 650.7 -3.5 -3493 0.1 CCDC17 GC01M045637 GPBP1L1
GH01J045622 Enhancer 0.5 ENCODE 650.7 +1.9 1863 0.2 SSRP1 RBM22 HNF4A ZBTB33 CCDC17 ENSG00000281825
GH01J045630 Promoter 0.5 EPDnew 650.4 -5.7 -5748 0.1 CCDC17 GPBP1L1 TMEM69 MAST2 HMGB1P48 PRDX1 GC01M045637
GH01J045801 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.6 -179.0 -178977 3.6 HDGF CLOCK ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 MAST2 GPBP1L1 CCDC163 EFCAB14-AS1 RPL7AP16 TOE1 LRRC41 MOB3C IPP CCDC17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC17 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • FAC1
  • Nkx2-5
  • STAT3
  • STAT2
  • STAT1beta
  • STAT1alpha
  • POU3F2
  • STAT4

Genomic Locations for CCDC17 Gene

Genomic Locations for CCDC17 Gene
chr1:45,620,044-45,624,787
(GRCh38/hg38)
Size:
4,744 bases
Orientation:
Minus strand
chr1:46,085,716-46,089,731
(GRCh37/hg19)
Size:
4,016 bases
Orientation:
Minus strand

Genomic View for CCDC17 Gene

Genes around CCDC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC17 Gene

Proteins for CCDC17 Gene

  • Protein details for CCDC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LX7-CCD17_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 17
    Protein Accession:
    Q96LX7
    Secondary Accessions:
    • A1A4Y7
    • B4DNX7
    • B4E1Q5
    • C9J8L2
    • Q0P683
    • Q5T629

    Protein attributes for CCDC17 Gene

    Size:
    622 amino acids
    Molecular mass:
    67721 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71539.1; Type=Miscellaneous discrepancy; Note=Incompletely spliced mRNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC17 Gene

Post-translational modifications for CCDC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC17 Gene

Domains & Families for CCDC17 Gene

Gene Families for CCDC17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC17: view

No data available for UniProtKB/Swiss-Prot for CCDC17 Gene

Function for CCDC17 Gene

Phenotypes From GWAS Catalog for CCDC17 Gene

Gene Ontology (GO) - Molecular Function for CCDC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC17: view
genes like me logo Genes that share phenotypes with CCDC17: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC17 Gene

Localization for CCDC17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC17 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC17 Gene

Pathways & Interactions for CCDC17 Gene

SuperPathways for CCDC17 Gene

No Data Available

Interacting Proteins for CCDC17 Gene

Gene Ontology (GO) - Biological Process for CCDC17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC17 Gene

Drugs & Compounds for CCDC17 Gene

No Compound Related Data Available

Transcripts for CCDC17 Gene

Unigene Clusters for CCDC17 Gene

Coiled-coil domain containing 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for CCDC17 Gene

GeneLoc Exon Structure for
CCDC17
ECgene alternative splicing isoforms for
CCDC17

Expression for CCDC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC17 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC17 Gene

This gene is overexpressed in Fallopian Tube (x11.5), Cervix - Endocervix (x6.2), Whole Blood (x4.5), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC17 Gene

This gene is overexpressed in Nasal epithelium (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC17 Gene



Protein tissue co-expression partners for CCDC17 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC17 Gene:

CCDC17

SOURCE GeneReport for Unigene cluster for CCDC17 Gene:

Hs.18912
genes like me logo Genes that share expression patterns with CCDC17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC17 Gene

Orthologs for CCDC17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC17 34 33
  • 99.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC17 34 33
  • 80.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC17 34 33
  • 78.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc17 16 34 33
  • 71.62 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc17 33
  • 71.51 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC17 34
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC17 34
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC17 34
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR854855.2 34
  • 27 (a)
OneToOne
Species where no ortholog for CCDC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC17 Gene

ENSEMBL:
Gene Tree for CCDC17 (if available)
TreeFam:
Gene Tree for CCDC17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC17: view image

Paralogs for CCDC17 Gene

No data available for Paralogs for CCDC17 Gene

Variants for CCDC17 Gene

Sequence variations from dbSNP and Humsavar for CCDC17 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000179916 -- 45,626,680(-) C/T upstream_transcript_variant
rs1001030214 -- 45,624,752(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1001558243 -- 45,622,527(-) G/C intron_variant
rs1001630531 -- 45,622,300(-) T/A coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1002172613 -- 45,624,973(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC17 Gene

Variant ID Type Subtype PubMed ID
esv3585911 CNV gain 21293372
esv3893512 CNV gain 25118596
nsv822509 CNV loss 20364138
nsv829726 CNV loss 17160897

Variation tolerance for CCDC17 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC17 Gene

Disorders for CCDC17 Gene

Additional Disease Information for CCDC17

No disorders were found for CCDC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC17 Gene

Publications for CCDC17 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CCDC17 Gene

Sources for CCDC17 Gene

Content
Loading form....