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Aliases for CCDC169 Gene

Aliases for CCDC169 Gene

  • Coiled-Coil Domain Containing 169 2 3 5
  • C13orf38 3 4
  • Coiled-Coil Domain-Containing Protein 169 3
  • Chromosome 13 Open Reading Frame 38 2
  • RP11-251J8.1 3

External Ids for CCDC169 Gene

Previous HGNC Symbols for CCDC169 Gene

  • C13orf38

Previous GeneCards Identifiers for CCDC169 Gene

  • GC13M036802

Summaries for CCDC169 Gene

GeneCards Summary for CCDC169 Gene

CCDC169 (Coiled-Coil Domain Containing 169) is a Protein Coding gene.

Additional gene information for CCDC169 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC169 Gene

Genomics for CCDC169 Gene

GeneHancer (GH) Regulatory Elements for CCDC169 Gene

Promoters and enhancers for CCDC169 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J036296 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.8 -1.2 -1185 4.2 ATF1 SIN3A FEZF1 GLI4 ZNF2 BRCA1 ETS1 POLR2B GLIS2 ZNF213 CCDC169 CCDC169-SOHLH2 SOHLH2 SPART-AS1
GH13J036343 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.3 -47.7 -47709 4.1 HDGF PKNOX1 SMAD1 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SPART SPART-AS1 SOHLH2 CCDC169 RFXAP CCDC169-SOHLH2
GH13J036130 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 12.4 +166.2 166204 2.7 ZSCAN4 SIN3A KLF14 ZNF335 ZNF121 GLIS2 ZNF366 EGR2 SP3 ZNF398 DCLK1 SOHLH2 EXOSC8 CCDC169 RFXAP SUPT20H NMTRQ-TTG10-1
GH13J036432 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 8.2 -134.4 -134446 0.6 KLF17 SIN3A BMI1 RFX5 GLIS2 EGR2 SP3 USF2 ZEB2 SREBF1 CCNA1 CCDC169 HIST1H2APS6
GH13J036154 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +142.8 142838 1.8 POLR2A SIN3A PRDM4 DCLK1 CCDC169 SOHLH2 SPART
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC169 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCDC169 Gene

Genomic Locations for CCDC169 Gene
chr13:36,222,008-36,297,855
(GRCh38/hg38)
Size:
75,848 bases
Orientation:
Minus strand
chr13:36,801,179-36,871,992
(GRCh37/hg19)
Size:
70,814 bases
Orientation:
Minus strand

Genomic View for CCDC169 Gene

Genes around CCDC169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC169 Gene

Proteins for CCDC169 Gene

  • Protein details for CCDC169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNP5-CC169_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 169
    Protein Accession:
    A6NNP5
    Secondary Accessions:
    • A6NC13
    • A6NCT2
    • B7ZW45
    • B7ZW49
    • B9EJF2
    • Q9H1T4
    • Q9H1T5

    Protein attributes for CCDC169 Gene

    Size:
    214 amino acids
    Molecular mass:
    25253 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC169 Gene

neXtProt entry for CCDC169 Gene

Post-translational modifications for CCDC169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC169 Gene

Domains & Families for CCDC169 Gene

Gene Families for CCDC169 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC169 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC169 Gene

Graphical View of Domain Structure for InterPro Entry

A6NNP5

UniProtKB/Swiss-Prot:

CC169_HUMAN :
  • Belongs to the CCDC169 family.
Family:
  • Belongs to the CCDC169 family.
genes like me logo Genes that share domains with CCDC169: view

Function for CCDC169 Gene

Phenotypes From GWAS Catalog for CCDC169 Gene

Phenotypes for CCDC169 Gene

genes like me logo Genes that share phenotypes with CCDC169: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC169 Gene

Localization for CCDC169 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC169 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC169 Gene

Pathways & Interactions for CCDC169 Gene

SuperPathways for CCDC169 Gene

No Data Available

Interacting Proteins for CCDC169 Gene

Gene Ontology (GO) - Biological Process for CCDC169 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC169 Gene

Drugs & Compounds for CCDC169 Gene

No Compound Related Data Available

Transcripts for CCDC169 Gene

mRNA/cDNA for CCDC169 Gene

(7) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC169 Gene

Coiled-coil domain containing 169:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC169 Gene

No ASD Table

Relevant External Links for CCDC169 Gene

GeneLoc Exon Structure for
CCDC169
ECgene alternative splicing isoforms for
CCDC169

Expression for CCDC169 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC169 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC169 Gene

This gene is overexpressed in Testis (x24.7).

Protein differential expression in normal tissues from HIPED for CCDC169 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC169 Gene



Protein tissue co-expression partners for CCDC169 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC169 Gene:

CCDC169

SOURCE GeneReport for Unigene cluster for CCDC169 Gene:

Hs.656745
genes like me logo Genes that share expression patterns with CCDC169: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC169 Gene

Orthologs for CCDC169 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC169 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CCDC169 34 33
  • 84.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc169 16 34 33
  • 77.26 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc169 33
  • 76.32 (n)
cow
(Bos Taurus)
Mammalia CCDC169 34
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC169 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC169 33
  • 62.12 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC169 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc169 33
  • 61.58 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc169 34 33
  • 52.02 (n)
OneToOne
Species where no ortholog for CCDC169 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC169 Gene

ENSEMBL:
Gene Tree for CCDC169 (if available)
TreeFam:
Gene Tree for CCDC169 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC169: view image

Paralogs for CCDC169 Gene

(1) SIMAP similar genes for CCDC169 Gene using alignment to 2 proteins:

  • CC169_HUMAN
  • E9PBZ7_HUMAN
genes like me logo Genes that share paralogs with CCDC169: view

No data available for Paralogs for CCDC169 Gene

Variants for CCDC169 Gene

Sequence variations from dbSNP and Humsavar for CCDC169 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000034709 -- 36,256,715(-) G/A intron_variant
rs1000039585 -- 36,298,659(-) A/C upstream_transcript_variant
rs1000066311 -- 36,294,868(-) T/C intron_variant
rs1000078128 -- 36,244,225(-) G/T intron_variant
rs1000116850 -- 36,294,639(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC169 Gene

Variant ID Type Subtype PubMed ID
dgv101e215 CNV deletion 23714750
dgv949n106 CNV deletion 24896259
esv1749604 CNV deletion 17803354
esv2095309 CNV deletion 18987734
esv2666917 CNV deletion 23128226
esv2671981 CNV deletion 23128226
esv2747263 CNV deletion 23290073
esv2747265 CNV deletion 23290073
esv2747266 CNV deletion 23290073
esv2747267 CNV deletion 23290073
esv3172209 CNV deletion 24192839
esv3550316 CNV deletion 23714750
esv3631777 CNV loss 21293372
esv3631778 CNV loss 21293372
esv3631780 CNV loss 21293372
nsv1070583 CNV deletion 25765185
nsv1138215 CNV deletion 24896259
nsv1149953 CNV deletion 26484159
nsv515635 CNV gain+loss 19592680
nsv525432 CNV loss 19592680

Variation tolerance for CCDC169 Gene

Gene Damage Index Score: 4.66; 65.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC169 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC169 Gene

Disorders for CCDC169 Gene

Additional Disease Information for CCDC169

No disorders were found for CCDC169 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC169 Gene

Publications for CCDC169 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for CCDC169 Gene

Sources for CCDC169 Gene

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