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Aliases for CCDC167 Gene

Aliases for CCDC167 Gene

  • Coiled-Coil Domain Containing 167 2 3 5
  • C6orf129 3 4
  • Transmembrane And Coiled-Coil Domain-Containing Protein C6orf129 3
  • Coiled-Coil Domain-Containing Protein 167 3
  • Chromosome 6 Open Reading Frame 129 2
  • HSPC265 3

External Ids for CCDC167 Gene

Previous HGNC Symbols for CCDC167 Gene

  • C6orf129

Previous GeneCards Identifiers for CCDC167 Gene

  • GC06M037450

Summaries for CCDC167 Gene

GeneCards Summary for CCDC167 Gene

CCDC167 (Coiled-Coil Domain Containing 167) is a Protein Coding gene.

Additional gene information for CCDC167 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC167 Gene

Genomics for CCDC167 Gene

GeneHancer (GH) Regulatory Elements for CCDC167 Gene

Promoters and enhancers for CCDC167 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I037498 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -2.7 -2692 7.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CCDC167 ENSG00000227920 SRSF3 STK38 CMTR1 LINC02520
GH06I037559 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -63.0 -63038 7.9 HDGF SMAD1 SIN3A ZNF2 IRF4 ZNF121 ARID2 ZNF143 ATF7 RUNX3 CCDC167 CMTR1 LINC02520 MDGA1 TBC1D22B SRSF3 TMEM217 ENSG00000279942 MIR4462
GH06I037547 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -51.7 -51738 9.3 HDGF PKNOX1 SMAD1 SIN3A IRF4 ZNF207 ZNF143 ATF7 FOS RUNX3 LINC02520 CCDC167 CMTR1 MIR4462 ENSG00000229559 ENSG00000227920
GH06I037556 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.1 -57.2 -57201 1 HDGF RB1 BACH1 EBF1 BATF IRF4 RELA POLR2A IKZF2 RUNX3 MIR4462 LINC02520 CCDC167 ENSG00000279942
GH06I037535 Enhancer 1 Ensembl dbSUPER 12 -36.2 -36177 1 HDAC1 KLF17 RAD21 ZNF335 TCF12 GLIS2 GATA2 EGR2 ZNF654 ZEB2 LINC02520 CCDC167 GC06M038608 ENSG00000227920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC167 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCDC167 Gene

Genomic Locations for CCDC167 Gene
chr6:37,482,920-37,499,924
(GRCh38/hg38)
Size:
17,005 bases
Orientation:
Minus strand
chr6:37,450,696-37,467,700
(GRCh37/hg19)

Genomic View for CCDC167 Gene

Genes around CCDC167 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC167 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC167 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC167 Gene

Proteins for CCDC167 Gene

  • Protein details for CCDC167 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0B6-CC167_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 167
    Protein Accession:
    Q9P0B6
    Secondary Accessions:
    • Q5T7F7
    • Q9BTQ9

    Protein attributes for CCDC167 Gene

    Size:
    97 amino acids
    Molecular mass:
    11459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH03515.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CCDC167 Gene

Post-translational modifications for CCDC167 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC167 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC167 Gene

Domains & Families for CCDC167 Gene

Gene Families for CCDC167 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CCDC167 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC167 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC167: view

No data available for UniProtKB/Swiss-Prot for CCDC167 Gene

Function for CCDC167 Gene

Phenotypes From GWAS Catalog for CCDC167 Gene

Phenotypes for CCDC167 Gene

GenomeRNAi human phenotypes for CCDC167:
genes like me logo Genes that share phenotypes with CCDC167: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC167 Gene

Localization for CCDC167 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC167 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC167 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCDC167: view

Pathways & Interactions for CCDC167 Gene

SuperPathways for CCDC167 Gene

No Data Available

Interacting Proteins for CCDC167 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362507%0d%0a9606.ENSP00000257262%0d%0a
Selected Interacting proteins: ENSP00000362507 Q9P0B6-CC167_HUMAN for CCDC167 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for CCDC167 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC167 Gene

Drugs & Compounds for CCDC167 Gene

No Compound Related Data Available

Transcripts for CCDC167 Gene

mRNA/cDNA for CCDC167 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(94) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC167 Gene

Coiled-coil domain containing 167:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC167 Gene

No ASD Table

Relevant External Links for CCDC167 Gene

GeneLoc Exon Structure for
CCDC167
ECgene alternative splicing isoforms for
CCDC167

Expression for CCDC167 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC167 Gene

Protein differential expression in normal tissues from HIPED for CCDC167 Gene

This gene is overexpressed in Bone (45.7) and Breast (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC167 Gene



Protein tissue co-expression partners for CCDC167 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC167 Gene:

CCDC167

SOURCE GeneReport for Unigene cluster for CCDC167 Gene:

Hs.284207

Evidence on tissue expression from TISSUES for CCDC167 Gene

  • Nervous system(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with CCDC167: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC167 Gene

Orthologs for CCDC167 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC167 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC167 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia CCDC167 33 34
  • 88.32 (n)
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCDC167 33 34
  • 87.97 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc167 33
  • 83.16 (n)
mouse
(Mus musculus)
Mammalia Ccdc167 33 16 34
  • 81.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC167 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC167 33 34
  • 65.25 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC167 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc167 33
  • 65.98 (n)
zebrafish
(Danio rerio)
Actinopterygii CCDC167 34
  • 38 (a)
OneToOne
Species where no ortholog for CCDC167 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC167 Gene

ENSEMBL:
Gene Tree for CCDC167 (if available)
TreeFam:
Gene Tree for CCDC167 (if available)

Paralogs for CCDC167 Gene

No data available for Paralogs for CCDC167 Gene

Variants for CCDC167 Gene

Sequence variations from dbSNP and Humsavar for CCDC167 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000146614 -- 37,493,636(-) C/A/T intron_variant
rs1000156841 -- 37,483,137(-) A/T 3_prime_UTR_variant
rs1000217259 -- 37,495,084(-) G/A intron_variant
rs1000310618 -- 37,493,158(-) GAAAGGCGAGGGAA/GAA intron_variant
rs1000379198 -- 37,496,647(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC167 Gene

Variant ID Type Subtype PubMed ID
esv2752124 CNV gain 17911159
esv3413317 CNV duplication 20981092
nsv1015689 CNV gain 25217958

Variation tolerance for CCDC167 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC167 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC167

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC167 Gene

Disorders for CCDC167 Gene

Additional Disease Information for CCDC167

No disorders were found for CCDC167 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC167 Gene

Publications for CCDC167 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai FF … Wheeler MB (The Journal of biological chemistry 2015) 3 58
  3. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 58
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A … Müller CR (Thrombosis and haemostasis 2011) 3 58

Products for CCDC167 Gene

Sources for CCDC167 Gene

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