Aliases for CCDC159 Gene

Aliases for CCDC159 Gene

  • Coiled-Coil Domain Containing 159 2 3 5
  • Coiled-Coil Domain-Containing Protein 159 3 4
  • CCDC159 5

External Ids for CCDC159 Gene

Previous GeneCards Identifiers for CCDC159 Gene

  • GC19P011321
  • GC19P011455
  • GC19P011033

Summaries for CCDC159 Gene

GeneCards Summary for CCDC159 Gene

CCDC159 (Coiled-Coil Domain Containing 159) is a Protein Coding gene.

Additional gene information for CCDC159 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC159 Gene

Genomics for CCDC159 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC159 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC159 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC159

Genomic Locations for CCDC159 Gene

Genomic Locations for CCDC159 Gene
chr19:11,344,684-11,354,951
(GRCh38/hg38)
Size:
10,268 bases
Orientation:
Plus strand
chr19:11,455,360-11,465,620
(GRCh37/hg19)
Size:
10,261 bases
Orientation:
Plus strand

Genomic View for CCDC159 Gene

Genes around CCDC159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC159 Gene

Proteins for CCDC159 Gene

  • Protein details for CCDC159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7I6-CC159_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 159
    Protein Accession:
    P0C7I6
    Secondary Accessions:
    • B4DEG3
    • B4DWR8
    • B4E133
    • B7ZAM4

    Protein attributes for CCDC159 Gene

    Size:
    297 amino acids
    Molecular mass:
    33695 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG63130.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BC038439; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC159 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC159 Gene

Post-translational modifications for CCDC159 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC159 Gene

Domains & Families for CCDC159 Gene

Gene Families for CCDC159 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC159 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC159 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 159 (CC159_HUMAN)
genes like me logo Genes that share domains with CCDC159: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC159 Gene

Function for CCDC159 Gene

Phenotypes From GWAS Catalog for CCDC159 Gene

Phenotypes for CCDC159 Gene

genes like me logo Genes that share phenotypes with CCDC159: view

Animal Models for CCDC159 Gene

MGI Knock Outs for CCDC159:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC159

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC159 Gene

Localization for CCDC159 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC159 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC159 Gene

Pathways & Interactions for CCDC159 Gene

PathCards logo

SuperPathways for CCDC159 Gene

No Data Available

Interacting Proteins for CCDC159 Gene

Selected Interacting proteins: P0C7I6-CC159_HUMAN for CCDC159 Gene via IID

Symbol External ID(s) Details
COIL

Gene Ontology (GO) - Biological Process for CCDC159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC159 Gene

Drugs & Compounds for CCDC159 Gene

No Compound Related Data Available

Transcripts for CCDC159 Gene

mRNA/cDNA for CCDC159 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC159

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC159 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9:

Relevant External Links for CCDC159 Gene

GeneLoc Exon Structure for
CCDC159

Expression for CCDC159 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC159

SOURCE GeneReport for Unigene cluster for CCDC159 Gene:

Hs.631636
genes like me logo Genes that share expression patterns with CCDC159: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC159 Gene

Orthologs for CCDC159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC159 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC159 30 31
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC159 30 31
  • 86.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC159 30 31
  • 83.56 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc159 30 17 31
  • 81.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc159 30
  • 80.68 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCDC159 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC159 31
  • 39 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC159 31
  • 40 (a)
OneToOne
Species where no ortholog for CCDC159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCDC159 Gene

ENSEMBL:
Gene Tree for CCDC159 (if available)
TreeFam:
Gene Tree for CCDC159 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC159: view image

Paralogs for CCDC159 Gene

No data available for Paralogs for CCDC159 Gene

Variants for CCDC159 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC159 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs6887 - p.Cys278Ser

Additional dbSNP identifiers (rs#s) for CCDC159 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC159 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv833752 CNV loss 17160897

Variation tolerance for CCDC159 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC159 Gene

Human Gene Mutation Database (HGMD)
CCDC159
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC159 Gene

Disorders for CCDC159 Gene

No disorders were found for CCDC159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC159 Gene

Publications for CCDC159 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J … Zoghbi HY (Cell 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for CCDC159 Gene

Sources for CCDC159 Gene