Free for academic non-profit institutions. Other users need a Commercial license

CCDC159 Gene(Protein Coding)

Coiled-Coil Domain Containing 159

GCID:
GC19P011344
GIFtS:
32
Genes Participants
UDN Logo

Aliases for CCDC159 Gene

Aliases for CCDC159 Gene

  • Coiled-Coil Domain Containing 159 2 3 5
  • Coiled-Coil Domain-Containing Protein 159 3 4

External Ids for CCDC159 Gene

Previous GeneCards Identifiers for CCDC159 Gene

  • GC19P011321
  • GC19P011455
  • GC19P011033

Summaries for CCDC159 Gene

GeneCards Summary for CCDC159 Gene

CCDC159 (Coiled-Coil Domain Containing 159) is a Protein Coding gene.

Additional gene information for CCDC159 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC159 Gene

Genomics for CCDC159 Gene

GeneHancer (GH) Regulatory Elements for CCDC159 Gene

Promoters and enhancers for CCDC159 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J011343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +1.1 1062 5 MTA3 CC2D1A SP1 ELF3 CBFA2T2 NKRF ZNF121 CEBPG ZNF687 NFIB CCDC159 PIR44072 TMEM205 PIR37751 RAB3D ILF3 KRI1 ZNF136 ZNF627 ZNF44
GH19J011373 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 +31.6 31636 6.2 CC2D1A SP1 ZFX CTCF CBFA2T2 NKRF POLR2A ZNF121 CEBPG GTF2F1 TMEM205 ENSG00000267277 SWSAP1 PIR61774 ILF3 ZNF136 KRI1 ZNF627 ZNF442 ZNF625
GH19J011379 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.2 +37.7 37682 5.1 HDGF CC2D1A ZFX SP1 ELF3 CTCF CBFA2T2 ZNF148 NKRF ZNF121 EPOR KRI1 ILF3 TIMM29 ZNF433 ZNF136 ZNF44 ZNF563 ZNF844 ZNF441
GH19J011086 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -252.3 -252314 11 SP1 ZFX ZNF652 ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 ZNF121 LDLR ILF3 ZNF491 ZNF844 ZNF441 ZNF627 ZNF823 KRI1 ZNF788P C19orf38
GH19J011567 Enhancer 1.2 FANTOM5 ENCODE 11.3 +223.6 223608 2.1 SP1 CBFA2T2 MLLT1 ZNF687 TRIM24 CREM ZNF639 SMARCA4 IKZF1 BACH1 CCDC159 ACP5 ELOF1 GC19M011558 ZNF627
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC159 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCDC159 Gene

Genomic Locations for CCDC159 Gene
chr19:11,344,684-11,354,944
(GRCh38/hg38)
Size:
10,261 bases
Orientation:
Plus strand
chr19:11,455,360-11,465,620
(GRCh37/hg19)
Size:
10,261 bases
Orientation:
Plus strand

Genomic View for CCDC159 Gene

Genes around CCDC159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC159 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC159 Gene

Proteins for CCDC159 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCDC159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7I6-CC159_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 159
    Protein Accession:
    P0C7I6
    Secondary Accessions:
    • B4DEG3
    • B4DWR8
    • B4E133
    • B7ZAM4

    Protein attributes for CCDC159 Gene

    Size:
    297 amino acids
    Molecular mass:
    33695 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG63130.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BC038439; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC159 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC159 Gene

Post-translational modifications for CCDC159 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC159 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC159 Gene

Domains & Families for CCDC159 Gene

Gene Families for CCDC159 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC159 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC159 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 159 (CC159_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC159: view

No data available for UniProtKB/Swiss-Prot for CCDC159 Gene

Function for CCDC159 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for CCDC159 Gene

genes like me logo Genes that share phenotypes with CCDC159: view

Animal Models for CCDC159 Gene

MGI Knock Outs for CCDC159:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC159 - Now 50% OFF >
  • * CCDC159 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC159 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC159 Gene

Localization for CCDC159 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC159 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC159 Gene

Pathways & Interactions for CCDC159 Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
PathCards logo

SuperPathways for CCDC159 Gene

No Data Available

Interacting Proteins for CCDC159 Gene

Selected Interacting proteins: P0C7I6-CC159_HUMAN for CCDC159 Gene via IID

Symbol External ID(s) Details
COIL
GPS-Prot Interaction Network for CCDC159

Gene Ontology (GO) - Biological Process for CCDC159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC159 Gene

Drugs & Compounds for CCDC159 Gene

Products:

  1. Drug
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
No Compound Related Data Available

Transcripts for CCDC159 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCDC159 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(142) Selected AceView cDNA sequences:
(20) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CCDC159 Gene

Coiled-coil domain containing 159:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC159 - Now 50% OFF >
  • * CCDC159 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC159 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC159 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9:

Relevant External Links for CCDC159 Gene

GeneLoc Exon Structure for
CCDC159
ECgene alternative splicing isoforms for
CCDC159

Expression for CCDC159 Gene

Products:

  1. Primer
  2. Gene Expression Assay
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC159 Gene

mRNA expression in normal human tissues for CCDC159 Gene
mRNA expression by GTEx for CCDC159 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC159 Gene:

CCDC159

SOURCE GeneReport for Unigene cluster for CCDC159 Gene:

Hs.631636
genes like me logo Genes that share expression patterns with CCDC159: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC159 Gene

Orthologs for CCDC159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC159 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC159 35 34
  • 99.1 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CCDC159 35 34
  • 86.89 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CCDC159 35 34
  • 83.56 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ccdc159 17 35 34
  • 81.48 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc159 34
  • 80.68 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCDC159 35
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CCDC159 35
  • 39 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CCDC159 35
  • 40 (a)
 OneToOne
Species where no ortholog for CCDC159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC159 Gene

ENSEMBL:
Gene Tree for CCDC159 (if available)
TreeFam:
Gene Tree for CCDC159 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC159: view image

Paralogs for CCDC159 Gene

No data available for Paralogs for CCDC159 Gene

Variants for CCDC159 Gene

Products:

  1. SNP Genotyping and Copy Number Assay
VarElect - NGS phenotyper. Rapid prioritization of variants from NGS data powered by 100+ GeneCards sources

Sequence variations from dbSNP and Humsavar for CCDC159 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000172972 -- 11,354,992(+) C/A downstream_transcript_variant
rs1000212178 -- 11,351,302(+) C/A/T intron_variant
rs1000270331 -- 11,344,732(+) G/C upstream_transcript_variant
rs1000949909 -- 11,349,770(+) C/T intron_variant
rs1001168866 -- 11,352,817(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC159 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv833752 CNV loss 17160897

Variation tolerance for CCDC159 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC159
Human Gene Mutation Database (HGMD)
CCDC159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC159 Gene

Disorders for CCDC159 Gene

Additional Disease Information for CCDC159

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC159 Gene

Publications for CCDC159 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J … Zoghbi HY (Cell 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

ExternalLinks

View latest publications for CCDC159 gene in Mastermind

Products for CCDC159 Gene

Sources for CCDC159 Gene

Content
Loading form....