Aliases for CCDC158 Gene

Aliases for CCDC158 Gene

  • Coiled-Coil Domain Containing 158 2 3 5
  • Coiled-Coil Domain-Containing Protein 158 3 4
  • FLJ25770 2
  • CCDC158 5

External Ids for CCDC158 Gene

Previous GeneCards Identifiers for CCDC158 Gene

  • GC04M077454
  • GC04M077234
  • GC04M072986

Summaries for CCDC158 Gene

GeneCards Summary for CCDC158 Gene

CCDC158 (Coiled-Coil Domain Containing 158) is a Protein Coding gene. An important paralog of this gene is MYH7B.

Additional gene information for CCDC158 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC158 Gene

Genomics for CCDC158 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC158 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC158 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC158

Top Transcription factor binding sites by QIAGEN in the CCDC158 gene promoter:
  • Evi-1
  • HSF1 (long)
  • HSF1short
  • HSF2
  • LCR-F1
  • Nkx2-5
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-4a

Genomic Locations for CCDC158 Gene

Genomic Locations for CCDC158 Gene
108,924 bases
Minus strand
108,868 bases
Minus strand

Genomic View for CCDC158 Gene

Genes around CCDC158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC158 Gene

Proteins for CCDC158 Gene

  • Protein details for CCDC158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 158
    Protein Accession:
    Secondary Accessions:
    • Q8IYQ1
    • Q8N7D4
    • Q8N7E3

    Protein attributes for CCDC158 Gene

    1113 amino acids
    Molecular mass:
    127140 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05347.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC035224; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC158 Gene


neXtProt entry for CCDC158 Gene

Post-translational modifications for CCDC158 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC158 Gene

Domains & Families for CCDC158 Gene

Gene Families for CCDC158 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC158 Gene


Suggested Antigen Peptide Sequences for CCDC158 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 158 (CD158_HUMAN)
genes like me logo Genes that share domains with CCDC158: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC158 Gene

Function for CCDC158 Gene

Phenotypes From GWAS Catalog for CCDC158 Gene

Phenotypes for CCDC158 Gene

genes like me logo Genes that share phenotypes with CCDC158: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC158

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC158 Gene

Localization for CCDC158 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC158 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC158 Gene

Pathways & Interactions for CCDC158 Gene

PathCards logo

SuperPathways for CCDC158 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC158 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC158 Gene

Drugs & Compounds for CCDC158 Gene

No Compound Related Data Available

Transcripts for CCDC158 Gene

mRNA/cDNA for CCDC158 Gene

6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC158

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC158 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: -
SP2: - - - - - - - - - - - -

ExUns: 22 ^ 23 ^ 24 ^ 25

Relevant External Links for CCDC158 Gene

GeneLoc Exon Structure for

Expression for CCDC158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC158 Gene

This gene is overexpressed in Testis (x30.8).

Protein differential expression in normal tissues from HIPED for CCDC158 Gene

This gene is overexpressed in Cervix (27.0), Lymph node (17.7), and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC158 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC158

SOURCE GeneReport for Unigene cluster for CCDC158 Gene:

genes like me logo Genes that share expression patterns with CCDC158: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC158 Gene

Orthologs for CCDC158 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC158 30 31
  • 99.55 (n)
(Canis familiaris)
Mammalia CCDC158 30 31
  • 91.19 (n)
(Bos Taurus)
Mammalia CCDC158 30 31
  • 90.5 (n)
(Mus musculus)
Mammalia Ccdc158 30 17 31
  • 85.95 (n)
(Rattus norvegicus)
Mammalia Ccdc158 30
  • 85.81 (n)
(Monodelphis domestica)
Mammalia CCDC158 31
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC158 31
  • 52 (a)
(Anolis carolinensis)
Reptilia CCDC158 31
  • 47 (a)
Species where no ortholog for CCDC158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCDC158 Gene

Gene Tree for CCDC158 (if available)
Gene Tree for CCDC158 (if available)
Evolutionary constrained regions (ECRs) for CCDC158: view image

Paralogs for CCDC158 Gene

Variants for CCDC158 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC158 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs17001885 - p.Ile297Val
rs17001889 - p.Glu232Asp

Additional dbSNP identifiers (rs#s) for CCDC158 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC158 Gene

Variant ID Type Subtype PubMed ID
esv2759262 CNV loss 17122850
esv3601052 CNV loss 21293372
nsv10526 CNV gain 18304495
nsv1128078 CNV deletion 24896259
nsv1161115 CNV deletion 26073780
nsv441891 CNV loss 18776908
nsv7363 OTHER inversion 18451855
nsv950056 CNV duplication 24416366
nsv967765 CNV duplication 23825009
nsv967766 CNV duplication 23825009

Variation tolerance for CCDC158 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC158 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC158 Gene

Disorders for CCDC158 Gene

Additional Disease Information for CCDC158

No disorders were found for CCDC158 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC158 Gene

Publications for CCDC158 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. (PMID: 29892012) Chen S … Yu H (Nature genetics 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for CCDC158 Gene

Sources for CCDC158 Gene