Aliases for CCDC157 Gene

Aliases for CCDC157 Gene

  • Coiled-Coil Domain Containing 157 2 3 5
  • Coiled-Coil Domain-Containing Protein 157 3 4
  • KIAA1656 4
  • CCDC157 5

External Ids for CCDC157 Gene

Previous GeneCards Identifiers for CCDC157 Gene

  • GC22P029082
  • GC22P030752
  • GC22P013714

Summaries for CCDC157 Gene

GeneCards Summary for CCDC157 Gene

CCDC157 (Coiled-Coil Domain Containing 157) is a Protein Coding gene. An important paralog of this gene is SMC1B.

Additional gene information for CCDC157 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC157 Gene

Genomics for CCDC157 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC157 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC157 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC157

Top Transcription factor binding sites by QIAGEN in the CCDC157 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2
  • p53
  • SRF

Genomic Locations for CCDC157 Gene

Genomic Locations for CCDC157 Gene
chr22:30,356,624-30,378,673
(GRCh38/hg38)
Size:
22,050 bases
Orientation:
Plus strand
chr22:30,752,624-30,774,647
(GRCh37/hg19)
Size:
22,024 bases
Orientation:
Plus strand

Genomic View for CCDC157 Gene

Genes around CCDC157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC157 Gene

Proteins for CCDC157 Gene

  • Protein details for CCDC157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q569K6-CC157_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 157
    Protein Accession:
    Q569K6
    Secondary Accessions:
    • Q0VD76
    • Q9BYA4

    Protein attributes for CCDC157 Gene

    Size:
    752 amino acids
    Molecular mass:
    83941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH92419.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5'- and 3'-ends and extensively differs from that shown due to multiple introns.; Evidence={ECO:0000305};

neXtProt entry for CCDC157 Gene

Post-translational modifications for CCDC157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC157 Gene

Domains & Families for CCDC157 Gene

Gene Families for CCDC157 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC157 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC157 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 157 (CC157_HUMAN)
genes like me logo Genes that share domains with CCDC157: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC157 Gene

Function for CCDC157 Gene

Phenotypes From GWAS Catalog for CCDC157 Gene

Phenotypes for CCDC157 Gene

genes like me logo Genes that share phenotypes with CCDC157: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC157

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC157 Gene

Localization for CCDC157 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC157 gene
Compartment Confidence
nucleus 2
cytosol 1
golgi apparatus 1
extracellular 0
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC157 Gene

Pathways & Interactions for CCDC157 Gene

PathCards logo

SuperPathways for CCDC157 Gene

No Data Available

Interacting Proteins for CCDC157 Gene

Gene Ontology (GO) - Biological Process for CCDC157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC157 Gene

Drugs & Compounds for CCDC157 Gene

No Compound Related Data Available

Transcripts for CCDC157 Gene

mRNA/cDNA for CCDC157 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC157

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC157 Gene

No ASD Table

Relevant External Links for CCDC157 Gene

GeneLoc Exon Structure for
CCDC157

Expression for CCDC157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC157 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC157 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for CCDC157 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC157 Gene



Protein tissue co-expression partners for CCDC157 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC157

SOURCE GeneReport for Unigene cluster for CCDC157 Gene:

Hs.505597

Evidence on tissue expression from TISSUES for CCDC157 Gene

  • Lung(4.6)
genes like me logo Genes that share expression patterns with CCDC157: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC157 Gene

Orthologs for CCDC157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC157 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC157 30 31
  • 99.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC157 30 31
  • 83.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC157 30 31
  • 83.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc157 30 17 31
  • 82.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc157 30
  • 81.85 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC157 31
  • 61 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC157 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC157 30 31
  • 60.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC157 31
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc157 30
  • 52.77 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc157 30 31
  • 51.84 (n)
OneToOne
Species where no ortholog for CCDC157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC157 Gene

ENSEMBL:
Gene Tree for CCDC157 (if available)
TreeFam:
Gene Tree for CCDC157 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC157: view image

Paralogs for CCDC157 Gene

Paralogs for CCDC157 Gene

(1) SIMAP similar genes for CCDC157 Gene using alignment to 4 proteins:

  • CC157_HUMAN
  • A8MUK5_HUMAN
  • E7ETG3_HUMAN
  • E7EWT0_HUMAN
genes like me logo Genes that share paralogs with CCDC157: view

Variants for CCDC157 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC157 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs12167903 - p.Pro191Leu
rs2015035 - p.Ser587Ala
rs740223 - p.Asp51Asn

Additional dbSNP identifiers (rs#s) for CCDC157 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC157 Gene

Variant ID Type Subtype PubMed ID
nsv1066179 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv953067 CNV deletion 24416366

Variation tolerance for CCDC157 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC157 Gene

Disorders for CCDC157 Gene

Additional Disease Information for CCDC157

No disorders were found for CCDC157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC157 Gene

Publications for CCDC157 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. (PMID: 31488582) Bassaganyas L … Villeneuve J (The Journal of cell biology 2019) 3
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon KS … Liu Q (Proceedings of the National Academy of Sciences of the United States of America 2014) 3
  4. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski MK … Reilly MP (BMC medical genetics 2013) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for CCDC157 Gene

Sources for CCDC157 Gene