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Aliases for CCDC157 Gene

Aliases for CCDC157 Gene

  • Coiled-Coil Domain Containing 157 2 3 5
  • Coiled-Coil Domain-Containing Protein 157 3
  • KIAA1656 4

External Ids for CCDC157 Gene

Previous GeneCards Identifiers for CCDC157 Gene

  • GC22P029082
  • GC22P030752
  • GC22P013714

Summaries for CCDC157 Gene

GeneCards Summary for CCDC157 Gene

CCDC157 (Coiled-Coil Domain Containing 157) is a Protein Coding gene.

Additional gene information for CCDC157 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC157 Gene

Genomics for CCDC157 Gene

GeneHancer (GH) Regulatory Elements for CCDC157 Gene

Promoters and enhancers for CCDC157 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J030355 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.3 -0.1 -124 2.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 CCDC157 SF3A1 RNF215 CASTOR1 SEC14L6 TBC1D10A
GH22J030322 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.7 -29.7 -29715 8 HDGF PKNOX1 ARID4B SIN3A YY1 GLIS2 ZNF213 ATF7 RUNX3 SP3 TBC1D10A RNF215 CCDC157 CASTOR1 SEC14L3 TUG1 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590
GH22J030287 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.7 -66.5 -66477 5 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF213 ZNF207 ZNF143 CASTOR1 RNF215 CCDC157 DUSP18 ENSG00000248751 TBC1D10A
GH22J030415 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +64.8 64804 11.6 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 RNF215 ENSG00000273350 MTFP1 RNU6-564P ENSG00000272689 TUG1 SF3A1 TBC1D10A SEC14L3 PES1
GH22J030300 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14 -45.7 -45650 20.9 HDGF PKNOX1 FOXA2 ARNT ZBTB7B IRF4 YY1 FOS JUNB REST RNF215 PES1 MORC2 TUG1 CASTOR1 SF3A1 CCDC157 SEC14L3 SEC14L2 MTMR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC157 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC157 gene promoter:

Genomic Locations for CCDC157 Gene

Genomic Locations for CCDC157 Gene
chr22:30,356,635-30,378,658
(GRCh38/hg38)
Size:
22,024 bases
Orientation:
Plus strand
chr22:30,752,624-30,774,647
(GRCh37/hg19)

Genomic View for CCDC157 Gene

Genes around CCDC157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC157 Gene

Proteins for CCDC157 Gene

  • Protein details for CCDC157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q569K6-CC157_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 157
    Protein Accession:
    Q569K6
    Secondary Accessions:
    • Q0VD76
    • Q9BYA4

    Protein attributes for CCDC157 Gene

    Size:
    752 amino acids
    Molecular mass:
    83941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH92419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5- and 3-ends and extensively differs from that shown due to multiple introns.; Evidence={ECO:0000305};

neXtProt entry for CCDC157 Gene

Post-translational modifications for CCDC157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC157 Gene

Domains & Families for CCDC157 Gene

Gene Families for CCDC157 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC157 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC157: view

No data available for UniProtKB/Swiss-Prot for CCDC157 Gene

Function for CCDC157 Gene

Phenotypes From GWAS Catalog for CCDC157 Gene

Phenotypes for CCDC157 Gene

genes like me logo Genes that share phenotypes with CCDC157: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC157 Gene

Localization for CCDC157 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC157 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC157 Gene

Pathways & Interactions for CCDC157 Gene

SuperPathways for CCDC157 Gene

No Data Available

Interacting Proteins for CCDC157 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343087%0d%0a9606.ENSP00000249079%0d%0a
Selected Interacting proteins: ENSP00000343087 Q569K6-CC157_HUMAN for CCDC157 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC157 Gene

Drugs & Compounds for CCDC157 Gene

No Compound Related Data Available

Transcripts for CCDC157 Gene

mRNA/cDNA for CCDC157 Gene

(5) Additional mRNA sequences :
(14) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC157 Gene

Coiled-coil domain containing 157:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC157 Gene

No ASD Table

Relevant External Links for CCDC157 Gene

GeneLoc Exon Structure for
CCDC157
ECgene alternative splicing isoforms for
CCDC157

Expression for CCDC157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC157 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC157 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for CCDC157 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC157 Gene



Protein tissue co-expression partners for CCDC157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC157 Gene:

CCDC157

SOURCE GeneReport for Unigene cluster for CCDC157 Gene:

Hs.505597

Evidence on tissue expression from TISSUES for CCDC157 Gene

  • Lung(4.6)
genes like me logo Genes that share expression patterns with CCDC157: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC157 Gene

Orthologs for CCDC157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC157 34 33
  • 99.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC157 34 33
  • 83.97 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC157 34 33
  • 83.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc157 16 34 33
  • 82.41 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc157 33
  • 81.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC157 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC157 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC157 34 33
  • 60.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC157 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc157 33
  • 52.77 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc157 34 33
  • 51.84 (n)
OneToOne
Species where no ortholog for CCDC157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC157 Gene

ENSEMBL:
Gene Tree for CCDC157 (if available)
TreeFam:
Gene Tree for CCDC157 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC157: view image

Paralogs for CCDC157 Gene

(1) SIMAP similar genes for CCDC157 Gene using alignment to 4 proteins:

  • CC157_HUMAN
  • A8MUK5_HUMAN
  • E7ETG3_HUMAN
  • E7EWT0_HUMAN
genes like me logo Genes that share paralogs with CCDC157: view

No data available for Paralogs for CCDC157 Gene

Variants for CCDC157 Gene

Sequence variations from dbSNP and Humsavar for CCDC157 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000078259 -- 30,363,797(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000471745 -- 30,368,341(+) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000545210 -- 30,368,511(+) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000598881 -- 30,362,518(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000937942 -- 30,356,181(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC157 Gene

Variant ID Type Subtype PubMed ID
nsv1066179 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv953067 CNV deletion 24416366

Variation tolerance for CCDC157 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC157 Gene

Disorders for CCDC157 Gene

Additional Disease Information for CCDC157

No disorders were found for CCDC157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC157 Gene

Publications for CCDC157 Gene

  1. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon KS … Liu Q (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58
  2. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski MK … Reilly MP (BMC medical genetics 2013) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CCDC157 Gene

Sources for CCDC157 Gene

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