Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC155 Gene

Aliases for CCDC155 Gene

  • Coiled-Coil Domain Containing 155 2 3 5
  • KASH Domain-Containing Protein 5 3 4
  • Protein KASH5 3 4
  • KASH5 3 4
  • Coiled-Coil Domain-Containing Protein 155 4

External Ids for CCDC155 Gene

Previous GeneCards Identifiers for CCDC155 Gene

  • GC19P054584
  • GC19P049891
  • GC19P046269

Summaries for CCDC155 Gene

GeneCards Summary for CCDC155 Gene

CCDC155 (Coiled-Coil Domain Containing 155) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and dynein complex binding. An important paralog of this gene is SSH2.

UniProtKB/Swiss-Prot for CCDC155 Gene

  • As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.

Additional gene information for CCDC155 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC155 Gene

Genomics for CCDC155 Gene

GeneHancer (GH) Regulatory Elements for CCDC155 Gene

Promoters and enhancers for CCDC155 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049387 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 635.7 -0.1 -117 1 ZNF148 TRIM24 SP1 GMEB1 POLR2A NRF1 MGA EGR1 ZBTB2 NFRKB CCDC155 LOC101928295 DKKL1
GH19J049359 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 32.6 -25.9 -25887 4.8 HDGF ZFX SP1 MNT ZNF148 MLLT1 GTF2F1 ZNF384 TFE3 SP7 DKKL1 TEAD2 CCDC155 ENSG00000204666
GH19J049332 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.9 -52.9 -52859 5 SP1 GTF2F1 ZNF687 RELA CREM MLLT1 SMARCA4 ZBED1 MTA1 IKZF1 CD37 SLC6A16 DKKL1 CCDC155 ALDH16A1 BCL2L12 FLT3LG IRF3 SNRNP70 ENSG00000197813
GH19J049326 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 31.2 -59.2 -59180 6.4 SP1 CTCF SIX5 CBFA2T2 ZNF121 CEBPG ZNF384 ZNF687 HNF1A CREM CCDC155 PTOV1-AS2 CYTH2 PRR12 SNRNP70 TMEM143 PTH2 SLC6A16 ENSG00000197813 MIR4324
GH19J049390 Enhancer 1.1 Ensembl ENCODE 35.4 +2.8 2783 2.8 ELF3 CC2D1A CTCF MLLT1 NFIB ZSCAN21 MCM2 TRIM24 PRDM1 EGR1 CCDC155 DKKL1 NUP62 GRWD1 BCL2L12 POLD1 AKT1S1 PRR12 MED25 CYTH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC155 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC155 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Egr-1
  • Egr-4
  • MyoD
  • Pax-5
  • TBP

Genomic Locations for CCDC155 Gene

Genomic Locations for CCDC155 Gene
chr19:49,388,218-49,417,999
(GRCh38/hg38)
Size:
29,782 bases
Orientation:
Plus strand
chr19:49,891,475-49,921,256
(GRCh37/hg19)
Size:
29,782 bases
Orientation:
Plus strand

Genomic View for CCDC155 Gene

Genes around CCDC155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC155 Gene

Proteins for CCDC155 Gene

  • Protein details for CCDC155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6L0-KASH5_HUMAN
    Recommended name:
    Protein KASH5
    Protein Accession:
    Q8N6L0
    Secondary Accessions:
    • Q96MC3

    Protein attributes for CCDC155 Gene

    Size:
    562 amino acids
    Molecular mass:
    62783 Da
    Quaternary structure:
    • Core component the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts (via the last 22 AA) with SUN1; this interaction mediates its telomere localization by forming a SUN1:KASH5 LINC complex. Component of a probable SUN2:KASH5 LINC complex. Self-associates. Interacts with DYNC1H1, DCTN1, DYNC1I1/2 and PAFAH1B1; suggesting the association with the dynein-dynactin motor complex.

neXtProt entry for CCDC155 Gene

Post-translational modifications for CCDC155 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCDC155 Gene

Domains & Families for CCDC155 Gene

Gene Families for CCDC155 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CCDC155 Gene

Suggested Antigen Peptide Sequences for CCDC155 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 155 (CC155_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6L0

UniProtKB/Swiss-Prot:

KASH5_HUMAN :
  • The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.
Domain:
  • The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.
genes like me logo Genes that share domains with CCDC155: view

Function for CCDC155 Gene

Molecular function for CCDC155 Gene

UniProtKB/Swiss-Prot Function:
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.

Phenotypes From GWAS Catalog for CCDC155 Gene

Gene Ontology (GO) - Molecular Function for CCDC155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
GO:0070840 dynein complex binding IEA --
genes like me logo Genes that share ontologies with CCDC155: view
genes like me logo Genes that share phenotypes with CCDC155: view

Animal Models for CCDC155 Gene

MGI Knock Outs for CCDC155:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC155 - Now 50% OFF >
  • * CCDC155 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC155 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC155 Gene

Localization for CCDC155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC155 Gene

Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus. Chromosome, telomere. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000250 UniProtKB:Q80VJ8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC155 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
cytosol 1
plasma membrane 0

Gene Ontology (GO) - Cellular Components for CCDC155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region ISS --
GO:0000800 lateral element IEA --
GO:0005634 nucleus IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CCDC155: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC155 Gene

Pathways & Interactions for CCDC155 Gene

PathCards logo

SuperPathways for CCDC155 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IEA --
GO:0007015 actin filament organization IEA --
GO:0007129 synapsis IEA --
GO:0007283 spermatogenesis IEA --
GO:0034397 telomere localization IEA --
genes like me logo Genes that share ontologies with CCDC155: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC155 Gene

Drugs & Compounds for CCDC155 Gene

No Compound Related Data Available

Transcripts for CCDC155 Gene

mRNA/cDNA for CCDC155 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CCDC155 Gene

Coiled-coil domain containing 155:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC155 - Now 50% OFF >
  • * CCDC155 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC155 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC155 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:

ExUns: 19b ^ 20 ^ 21 ^ 22
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CCDC155 Gene

GeneLoc Exon Structure for
CCDC155
ECgene alternative splicing isoforms for
CCDC155

Expression for CCDC155 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC155 Gene

This gene is overexpressed in Testis (x36.5), Brain - Cerebellum (x7.9), and Brain - Cerebellar Hemisphere (x6.0).

Protein differential expression in normal tissues from HIPED for CCDC155 Gene

This gene is overexpressed in Cervix (45.2), Pancreas (15.2), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC155 Gene



Protein tissue co-expression partners for CCDC155 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC155 Gene:

CCDC155

SOURCE GeneReport for Unigene cluster for CCDC155 Gene:

Hs.662085

Evidence on tissue expression from TISSUES for CCDC155 Gene

  • Nervous system(4.4)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with CCDC155: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC155 Gene

Orthologs for CCDC155 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC155 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC155 35 34
  • 97.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC155 34 35
  • 85.16 (n)
dog
(Canis familiaris)
Mammalia CCDC155 34 35
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc155 34
  • 77.88 (n)
mouse
(Mus musculus)
Mammalia Ccdc155 35 34 17
  • 77.72 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC155 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC155 35
  • 42 (a)
OneToOne
Species where no ortholog for CCDC155 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC155 Gene

ENSEMBL:
Gene Tree for CCDC155 (if available)
TreeFam:
Gene Tree for CCDC155 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC155: view image

Paralogs for CCDC155 Gene

Variants for CCDC155 Gene

Sequence variations from dbSNP and Humsavar for CCDC155 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000068216 -- 49,396,005(+) G/A intron_variant
rs1000265311 -- 49,418,129(+) C/A downstream_transcript_variant
rs1000318023 -- 49,418,344(+) G/A/C downstream_transcript_variant
rs1000409938 -- 49,396,533(+) C/T intron_variant
rs1000426032 -- 49,402,479(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC155 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
esv2718713 CNV deletion 23290073
esv2718714 CNV deletion 23290073
esv3644623 CNV loss 21293372
nsv138000 CNV insertion 16902084
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for CCDC155 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC155 Gene

Disorders for CCDC155 Gene

Additional Disease Information for CCDC155

No disorders were found for CCDC155 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC155 Gene

Publications for CCDC155 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 58
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58

Products for CCDC155 Gene

Sources for CCDC155 Gene

Content
Loading form....