Aliases for CCDC155 Gene
External Ids for CCDC155 Gene
Previous GeneCards Identifiers for CCDC155 Gene
GeneCards Summary for CCDC155 Gene
CCDC155 (Coiled-Coil Domain Containing 155) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and dynein complex binding. An important paralog of this gene is SSH2.
UniProtKB/Swiss-Prot for CCDC155 Gene
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.