Aliases for CCDC154 Gene

Aliases for CCDC154 Gene

  • Coiled-Coil Domain Containing 154 2 3 5
  • Coiled-Coil Domain-Containing Protein 154 3 4
  • C16orf29 3 4
  • Chromosome 16 Open Reading Frame 29 2
  • LOC645811 2
  • CCDC154 5

External Ids for CCDC154 Gene

Previous HGNC Symbols for CCDC154 Gene

  • C16orf29

Previous GeneCards Identifiers for CCDC154 Gene

  • GC16M001426
  • GC16M001484
  • GC16M001412
  • GC16M001439
  • GC16M001490
  • GC16M001496
  • GC16M001510
  • GC16M001526
  • GC16M001445
  • GC16M001453
  • GC16M001458
  • GC16M001462
  • GC16M001466
  • GC16M001471

Summaries for CCDC154 Gene

GeneCards Summary for CCDC154 Gene

CCDC154 (Coiled-Coil Domain Containing 154) is a Protein Coding gene. Diseases associated with CCDC154 include Osteopetrosis and Hypoplastic Left Heart Syndrome.

Additional gene information for CCDC154 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC154 Gene

Genomics for CCDC154 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC154 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC154 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC154

Top Transcription factor binding sites by QIAGEN in the CCDC154 gene promoter:
  • HOXA9
  • HOXA9B
  • IRF-1
  • ITF-2
  • Meis-1
  • Meis-1b
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta
  • YY1

Genomic Locations for CCDC154 Gene

Genomic Locations for CCDC154 Gene
chr16:1,434,383-1,444,556
(GRCh38/hg38)
Size:
10,174 bases
Orientation:
Minus strand
chr16:1,484,384-1,494,557
(GRCh37/hg19)
Size:
10,174 bases
Orientation:
Minus strand

Genomic View for CCDC154 Gene

Genes around CCDC154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC154 Gene

Proteins for CCDC154 Gene

  • Protein details for CCDC154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI56-CC154_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 154
    Protein Accession:
    A6NI56
    Secondary Accessions:
    • G9JV18

    Protein attributes for CCDC154 Gene

    Size:
    667 amino acids
    Molecular mass:
    75408 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpression suppresses cell proliferation by inducing G2/M arrest.

neXtProt entry for CCDC154 Gene

Post-translational modifications for CCDC154 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC154 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC154 Gene

Domains & Families for CCDC154 Gene

Gene Families for CCDC154 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC154 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC154 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 154 (CC154_HUMAN)
genes like me logo Genes that share domains with CCDC154: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC154 Gene

Function for CCDC154 Gene

Phenotypes From GWAS Catalog for CCDC154 Gene

genes like me logo Genes that share phenotypes with CCDC154: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC154

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC154 Gene

Localization for CCDC154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC154 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC154 gene
Compartment Confidence
endosome 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CCDC154: view

Pathways & Interactions for CCDC154 Gene

PathCards logo

SuperPathways for CCDC154 Gene

No Data Available

Interacting Proteins for CCDC154 Gene

Gene Ontology (GO) - Biological Process for CCDC154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC154 Gene

Drugs & Compounds for CCDC154 Gene

No Compound Related Data Available

Transcripts for CCDC154 Gene

mRNA/cDNA for CCDC154 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC154

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC154 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
SP1:
SP2: -
SP3: - -
SP4:
SP5: -

Relevant External Links for CCDC154 Gene

GeneLoc Exon Structure for
CCDC154

Expression for CCDC154 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC154 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC154 Gene

This gene is overexpressed in Testis (x7.0) and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC154 Gene

This gene is overexpressed in Gallbladder (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC154 Gene



Protein tissue co-expression partners for CCDC154 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC154

SOURCE GeneReport for Unigene cluster for CCDC154 Gene:

Hs.355232
genes like me logo Genes that share expression patterns with CCDC154: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC154 Gene

Orthologs for CCDC154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC154 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC154 30 31
  • 97.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC154 30 31
  • 79.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC154 30 31
  • 76.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc154 30
  • 75.13 (n)
Mouse
(Mus musculus)
Mammalia Ccdc154 30 17 31
  • 74.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC154 31
  • 48 (a)
OneToOne
Species where no ortholog for CCDC154 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCDC154 Gene

ENSEMBL:
Gene Tree for CCDC154 (if available)
TreeFam:
Gene Tree for CCDC154 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC154: view image

Paralogs for CCDC154 Gene

No data available for Paralogs for CCDC154 Gene

Variants for CCDC154 Gene

Additional dbSNP identifiers (rs#s) for CCDC154 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC154 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv457331 CNV loss 19166990
nsv471066 CNV loss 18288195
nsv471068 CNV gain 18288195
nsv571160 CNV loss 21841781
nsv571161 CNV gain 21841781
nsv817713 CNV loss 17921354
nsv819259 CNV gain 19587683
nsv819844 CNV gain 19587683
nsv952899 CNV deletion 24416366

Variation tolerance for CCDC154 Gene

Gene Damage Index Score: 7.61; 82.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC154 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC154 Gene

Disorders for CCDC154 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CCDC154 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
osteopetrosis
  • albers-schonberg osteopetrosis
hypoplastic left heart syndrome
  • hlhs
left ventricular noncompaction
  • left ventricular hypertrabeculation
tetralogy of fallot
  • tof
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CCDC154: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC154 Gene

Publications for CCDC154 Gene

  1. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. (PMID: 22895184) Liao W … Lu X (Cell cycle (Georgetown, Tex.) 2012) 3 4
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for CCDC154 Gene

Sources for CCDC154 Gene