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Aliases for CCDC153 Gene

Aliases for CCDC153 Gene

  • Coiled-Coil Domain Containing 153 2 3 5
  • Coiled-Coil Domain-Containing Protein 153 3

External Ids for CCDC153 Gene

Previous GeneCards Identifiers for CCDC153 Gene

  • GC11M118567
  • GC11M119060
  • GC11M115000

Summaries for CCDC153 Gene

GeneCards Summary for CCDC153 Gene

CCDC153 (Coiled-Coil Domain Containing 153) is a Protein Coding gene. Diseases associated with CCDC153 include Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia.

Additional gene information for CCDC153 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC153 Gene

Genomics for CCDC153 Gene

GeneHancer (GH) Regulatory Elements for CCDC153 Gene

Promoters and enhancers for CCDC153 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J119205 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 -0.3 -291 3.1 SIN3A YY1 GLIS2 ZNF143 KLF7 ATF7 RUNX3 KLF13 SP3 RXRA CBL CCDC153 GC11M119206 RPL5P30 GC11M119252
GH11J119195 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 650.4 +10.4 10385 0.2 PKNOX1 DDX20 NEUROD1 BMI1 SCRT2 PRDM10 FOS SCRT1 RFX1 MAZ CCDC153 PIR45666 GC11M119206
GH11J118433 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE dbSUPER 5.1 +768.2 768198 8.2 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 KMT2A VPS11 HINFP ARCN1 TMEM25 CCDC84 IFT46 UBE4A THY1 BCL9L
GH11J119106 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.2 +98.3 98307 3.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 POLR2B DPAGT1 C2CD2L HINFP CCDC84 ARCN1 VPS11 ENSG00000254909 UBE4A RPL23AP64 ENSG00000254428
GH11J118529 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.6 +675.4 675364 3.3 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 LOC101929089 TMEM25 GC11P118532 ENSG00000254909 UBE4A BCL9L RPL23AP64 ARCN1 IFT46 ENSG00000254428
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC153 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC153 gene promoter:

Genomic Locations for CCDC153 Gene

Genomic Locations for CCDC153 Gene
chr11:119,189,638-119,206,286
(GRCh38/hg38)
Size:
16,649 bases
Orientation:
Minus strand
chr11:119,060,347-119,067,479
(GRCh37/hg19)

Genomic View for CCDC153 Gene

Genes around CCDC153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC153 Gene

Proteins for CCDC153 Gene

  • Protein details for CCDC153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q494R4-CC153_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 153
    Protein Accession:
    Q494R4

    Protein attributes for CCDC153 Gene

    Size:
    210 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC153 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC153 Gene

Post-translational modifications for CCDC153 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC153 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC153 Gene

Domains & Families for CCDC153 Gene

Gene Families for CCDC153 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC153 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q494R4

UniProtKB/Swiss-Prot:

CC153_HUMAN :
  • Belongs to the UPF0610 family.
Family:
  • Belongs to the UPF0610 family.
genes like me logo Genes that share domains with CCDC153: view

Function for CCDC153 Gene

Phenotypes From GWAS Catalog for CCDC153 Gene

Gene Ontology (GO) - Molecular Function for CCDC153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC153: view

Phenotypes for CCDC153 Gene

genes like me logo Genes that share phenotypes with CCDC153: view

Animal Model Products

miRNA for CCDC153 Gene

miRTarBase miRNAs that target CCDC153

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC153 Gene

Localization for CCDC153 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC153 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC153 Gene

Pathways & Interactions for CCDC153 Gene

SuperPathways for CCDC153 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC153 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC153 Gene

Drugs & Compounds for CCDC153 Gene

No Compound Related Data Available

Transcripts for CCDC153 Gene

mRNA/cDNA for CCDC153 Gene

(8) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
-
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC153 Gene

Coiled-coil domain containing 153:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC153 Gene

No ASD Table

Relevant External Links for CCDC153 Gene

GeneLoc Exon Structure for
CCDC153
ECgene alternative splicing isoforms for
CCDC153

Expression for CCDC153 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC153 Gene

This gene is overexpressed in Pituitary (x6.1) and Testis (x5.5).

Protein differential expression in normal tissues from HIPED for CCDC153 Gene

This gene is overexpressed in Adipocyte (33.2), Heart (26.9), and Pancreatic juice (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC153 Gene



Protein tissue co-expression partners for CCDC153 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC153 Gene:

CCDC153

SOURCE GeneReport for Unigene cluster for CCDC153 Gene:

Hs.114777
genes like me logo Genes that share expression patterns with CCDC153: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC153 Gene

Orthologs for CCDC153 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC153 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC153 34 33
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC153 34 33
  • 81.74 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc153 16 34 33
  • 78.73 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc153 33
  • 78.73 (n)
cow
(Bos Taurus)
Mammalia CCDC153 34 33
  • 76.88 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC153 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC153 34 33
  • 57.29 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc153 33
  • 50.17 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc153 34 33
  • 47.91 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for CCDC153 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC153 Gene

ENSEMBL:
Gene Tree for CCDC153 (if available)
TreeFam:
Gene Tree for CCDC153 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC153: view image

Paralogs for CCDC153 Gene

No data available for Paralogs for CCDC153 Gene

Variants for CCDC153 Gene

Sequence variations from dbSNP and Humsavar for CCDC153 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs371567712 likely-benign, not specified, Rasopathy 119,206,429(-) C/T upstream_transcript_variant
rs373212940 uncertain-significance, benign, conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Rasopathy, Noonan-Like Syndrome Disorder, not provided 119,206,523(-) CACCACCACCACCACCACCACC/CACCACCACC/CACCACCACCACC/CACCACCACCACCACCACC/CACCACCACCACCACCACCACCACC/CACCACCACCACCACCACCACCACCACC upstream_transcript_variant
rs376679438 uncertain-significance, Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 119,206,510(-) C/A upstream_transcript_variant
rs527849757 likely-benign, Noonan-Like Syndrome Disorder 119,206,261(-) A/G upstream_transcript_variant
rs548262208 likely-benign, Noonan-Like Syndrome Disorder 119,206,322(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC153 Gene

Variant ID Type Subtype PubMed ID
esv3627886 CNV loss 21293372
nsv556467 CNV loss 21841781
nsv556468 CNV loss 21841781

Variation tolerance for CCDC153 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC153 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC153 Gene

Disorders for CCDC153 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC153 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC153

genes like me logo Genes that share disorders with CCDC153: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC153 Gene

Publications for CCDC153 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CCDC153 Gene

Sources for CCDC153 Gene

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