Aliases for CCDC152 Gene

Aliases for CCDC152 Gene

  • Coiled-Coil Domain Containing 152 2 3 5
  • Coiled-Coil Domain-Containing Protein 152 3 4
  • CH5400 3

External Ids for CCDC152 Gene

Previous GeneCards Identifiers for CCDC152 Gene

  • GC05P042793

Summaries for CCDC152 Gene

GeneCards Summary for CCDC152 Gene

CCDC152 (Coiled-Coil Domain Containing 152) is a Protein Coding gene. Diseases associated with CCDC152 include Hemochromatosis Type 2.

Additional gene information for CCDC152 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC152 Gene

Genomics for CCDC152 Gene

GeneHancer (GH) Regulatory Elements for CCDC152 Gene

Promoters and enhancers for CCDC152 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC152 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC152

Top Transcription factor binding sites by QIAGEN in the CCDC152 gene promoter:
  • CUTL1
  • HSF1 (long)
  • HSF1short
  • HSF2
  • Nkx2-2
  • Nkx6-1
  • POU2F1
  • POU2F1a

Genomic Locations for CCDC152 Gene

Genomic Locations for CCDC152 Gene
chr5:42,756,818-42,802,439
(GRCh38/hg38)
Size:
45,622 bases
Orientation:
Plus strand
chr5:42,756,903-42,802,539
(GRCh37/hg19)
Size:
45,637 bases
Orientation:
Plus strand

Genomic View for CCDC152 Gene

Genes around CCDC152 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC152 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC152 Gene

Proteins for CCDC152 Gene

  • Protein details for CCDC152 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0S7-CC152_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 152
    Protein Accession:
    Q4G0S7
    Secondary Accessions:
    • B3KXI4
    • B4E0P7
    • Q5BLP6

    Protein attributes for CCDC152 Gene

    Size:
    254 amino acids
    Molecular mass:
    29979 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39102.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC152 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC152 Gene

Post-translational modifications for CCDC152 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC152 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC152 Gene

Domains & Families for CCDC152 Gene

Gene Families for CCDC152 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC152 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC152 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50334 (B4E0P7_HUMAN)
  • Coiled-coil domain-containing protein 152 (CC152_HUMAN)
genes like me logo Genes that share domains with CCDC152: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC152 Gene

Function for CCDC152 Gene

Phenotypes From GWAS Catalog for CCDC152 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC152 Gene

Localization for CCDC152 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC152 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC152 Gene

Pathways & Interactions for CCDC152 Gene

PathCards logo

SuperPathways for CCDC152 Gene

No Data Available

Interacting Proteins for CCDC152 Gene

Selected Interacting proteins: Q4G0S7-CC152_HUMAN for CCDC152 Gene via IID

Symbol External ID(s) Details
FAM161B
PRR11
;

Gene Ontology (GO) - Biological Process for CCDC152 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC152 Gene

Drugs & Compounds for CCDC152 Gene

No Compound Related Data Available

Transcripts for CCDC152 Gene

mRNA/cDNA for CCDC152 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC152 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - - - -
SP12: - - - - - - - - - - -
SP13: - - -
SP14: -
SP15: - - - - - - - -

Relevant External Links for CCDC152 Gene

GeneLoc Exon Structure for
CCDC152

Expression for CCDC152 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC152 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC152 Gene

This gene is overexpressed in Tonsil (29.7), Oral epithelium (20.4), and Monocytes (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC152 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC152

mRNA Expression by UniProt/SwissProt for CCDC152 Gene:

Q4G0S7-CC152_HUMAN
Tissue specificity: Detected in stomach.
genes like me logo Genes that share expression patterns with CCDC152: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC152 Gene

Orthologs for CCDC152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC152 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC152 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC152 31 30
  • 90.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC152 31 30
  • 88.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc152 17 31 30
  • 83.73 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc152 30
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC152 31
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC152 31
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC152 31 30
  • 70.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC152 31
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc152 30
  • 61.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886863 30
  • 54.21 (n)
Species where no ortholog for CCDC152 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC152 Gene

ENSEMBL:
Gene Tree for CCDC152 (if available)
TreeFam:
Gene Tree for CCDC152 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC152: view image

Paralogs for CCDC152 Gene

No data available for Paralogs for CCDC152 Gene

Variants for CCDC152 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC152 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
783435 Benign: not provided 42,801,176(+) T/C SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
rs6879044 - p.Arg251His

Additional dbSNP identifiers (rs#s) for CCDC152 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC152 Gene

Variant ID Type Subtype PubMed ID
dgv5637n100 CNV gain 25217958
esv3604874 CNV gain 21293372
nsv462126 CNV gain 19166990
nsv523033 CNV gain 19592680
nsv597886 CNV gain 21841781
nsv597925 CNV gain 21841781

Variation tolerance for CCDC152 Gene

Gene Damage Index Score: 1.75; 33.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC152 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC152

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC152 Gene

Disorders for CCDC152 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC152 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemochromatosis type 2
  • hfe2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC152

genes like me logo Genes that share disorders with CCDC152: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC152 Gene

Publications for CCDC152 Gene

  1. Comparative gene finding in chicken indicates that we are closing in on the set of multi-exonic widely expressed human genes. (PMID: 15809229) Castelo R … Eyras E (Nucleic acids research 2005) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for CCDC152 Gene

Sources for CCDC152 Gene