CCDC15 Gene (Protein Coding)

Coiled-Coil Domain Containing 15

GC11P124954
GIFtS:
31
See more...

Aliases for CCDC15 Gene

Aliases for CCDC15 Gene

  • Coiled-Coil Domain Containing 15 2 3 5
  • Coiled-Coil Domain-Containing Protein 15 3 4
  • FLJ13215 2
  • CCDC15 5

External Ids for CCDC15 Gene

Previous GeneCards Identifiers for CCDC15 Gene

  • GC11P124330
  • GC11P124824
  • GC11P120766

Summaries for CCDC15 Gene

GeneCards Summary for CCDC15 Gene

CCDC15 (Coiled-Coil Domain Containing 15) is a Protein Coding gene.

Additional gene information for CCDC15 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC15 Gene

Genomics for CCDC15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CCDC15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC15

Top Transcription factor binding sites by QIAGEN in the CCDC15 gene promoter:
  • C/EBPbeta
  • FOXO4
  • Lhx3a
  • LHX3b
  • Max1
  • MEF-2
  • MEF-2A
  • SRF
  • SRF (504 AA)

Genomic Locations for CCDC15 Gene

Latest Assembly
chr11:124,954,121-125,041,489
(GRCh38/hg38)
Size:
87,369 bases
Orientation:
Plus strand

Previous Assembly
chr11:124,824,098-124,911,385
(GRCh37/hg19 by Entrez Gene)
Size:
87,288 bases
Orientation:
Plus strand

chr11:124,824,017-124,911,385
(GRCh37/hg19 by Ensembl)
Size:
87,369 bases
Orientation:
Plus strand

Genomic View for CCDC15 Gene

Genes around CCDC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC15 Gene

Proteins for CCDC15 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for CCDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P6D6-CCD15_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 15
    Protein Accession:
    Q0P6D6
    Secondary Accessions:
    • Q9H8U7

    Protein attributes for CCDC15 Gene

    Size:
    951 amino acids
    Molecular mass:
    110484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH18540.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for CCDC15 Gene

Protein Expression for CCDC15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC15 Gene

  • Ubiquitination at Lys128, Lys443, Lys595, Lys725, and Lys848
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC15 Gene

Domains & Families for CCDC15 Gene

Gene Families for CCDC15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC15 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 15 (CCD15_HUMAN)
genes like me logo Genes that share domains with CCDC15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC15 Gene

Function for CCDC15 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for CCDC15 Gene

genes like me logo Genes that share phenotypes with CCDC15: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC15 Gene

Localization for CCDC15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC15 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 3
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IBA,IDA 21399614
genes like me logo Genes that share ontologies with CCDC15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC15 Gene

Pathways & Interactions for CCDC15 Gene

PathCards logo

SuperPathways for CCDC15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC15 Gene

Drugs & Compounds for CCDC15 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for CCDC15 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for CCDC15 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC15

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC15 Gene

No ASD Table

Relevant External Links for CCDC15 Gene

GeneLoc Exon Structure for
CCDC15

Expression for CCDC15 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC15 Gene

mRNA expression in normal human tissues for CCDC15 Gene
mRNA expression by BioGPS for CCDC15 GenemRNA expression by GTEx for CCDC15 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC15 Gene

This gene is overexpressed in Testis (x10.9).

Protein differential expression in normal tissues from HIPED for CCDC15 Gene

This gene is overexpressed in Plasma (61.9) and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC15 Gene



Protein tissue co-expression partners for CCDC15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC15

SOURCE GeneReport for Unigene cluster for CCDC15 Gene:

Hs.287555
genes like me logo Genes that share expression patterns with CCDC15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC15 Gene

Orthologs for CCDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CCDC15 30 31
  • 98.67 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CCDC15 30 31
  • 78.56 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CCDC15 30 31
  • 77.29 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ccdc15 30 17 31
  • 75.92 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ccdc15 30
  • 73.92 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 55 (a)
 OneToMany
-- 31
  • 46 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia CCDC15 31
  • 27 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CCDC15 30 31
  • 57.51 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CCDC15 31
  • 39 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ccdc15 30
  • 58.4 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC100333818 30
  • 51.56 (n)
CCDC15 31
  • 33 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 26 (a)
 OneToOne
Species where no ortholog for CCDC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC15 Gene

ENSEMBL:
Gene Tree for CCDC15 (if available)
TreeFam:
Gene Tree for CCDC15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC15: view image

Paralogs for CCDC15 Gene

No data available for Paralogs for CCDC15 Gene

Variants for CCDC15 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC15 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs141534483 Benign: not provided 124,954,762(+) T/C
NM_025004.3(CCDC15):c.30T>C (p.Pro10=) 		SYNONYMOUS
rs386352386 Uncertain Significance: not provided 124,987,126(+) G/C
NM_025004.3(CCDC15):c.901-1G>C 		SPLICE_ACCEPTOR
rs61521463 Benign: not provided 124,959,828(+) G/C
NM_025004.3(CCDC15):c.341G>C (p.Gly114Ala) 		MISSENSE
rs4936966 - p.Gly529Asp
rs7107487 - p.Cys813Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC15 Gene

Variant ID Type Subtype PubMed ID
esv1770401 CNV deletion 17803354
esv2256616 CNV deletion 18987734
esv2479047 CNV deletion 19546169
esv2745189 CNV deletion 23290073
esv2745190 CNV deletion 23290073
esv2745191 CNV deletion 23290073
esv2745192 CNV deletion 23290073
esv2745193 CNV deletion 23290073
esv3548468 CNV deletion 23714750
esv996549 CNV deletion 20482838
nsv1054682 CNV gain 25217958
nsv1125537 CNV tandem duplication 24896259
nsv1138084 CNV deletion 24896259
nsv1144597 CNV deletion 24896259
nsv39015 CNV deletion 16902084
nsv520010 CNV loss 19592680
nsv957899 CNV deletion 24416366

Variation tolerance for CCDC15 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC15 Gene

Disorders for CCDC15 Gene

Additional Disease Information for CCDC15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CCDC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC15 Gene

Publications for CCDC15 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response. (PMID: 30979931) Roewenstrunk J … de la Luna S (Scientific reports 2019) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

ExternalLinks

View latest publications for CCDC15 gene in Mastermind

Products for CCDC15 Gene

Sources for CCDC15 Gene