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CCDC15 Gene(Protein Coding)

Coiled-Coil Domain Containing 15

GCID:
GC11P124954
GIFtS:
37
Genes Participants
UDN Logo

Aliases for CCDC15 Gene

Aliases for CCDC15 Gene

  • Coiled-Coil Domain Containing 15 2 3 5
  • Coiled-Coil Domain-Containing Protein 15 3

External Ids for CCDC15 Gene

Previous GeneCards Identifiers for CCDC15 Gene

  • GC11P124330
  • GC11P124824
  • GC11P120766

Summaries for CCDC15 Gene

GeneCards Summary for CCDC15 Gene

CCDC15 (Coiled-Coil Domain Containing 15) is a Protein Coding gene.

Additional gene information for CCDC15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC15 Gene

Genomics for CCDC15 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CCDC15 Gene

Promoters and enhancers for CCDC15 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J124953 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 711 0.0 -2 2.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 CCDC15 LOC105369547 ROBO4 ROBO3
GH11J124952 Enhancer 0.5 ENCODE dbSUPER 650.7 -1.2 -1240 0.1 CBFA2T3 LOC105369547 CCDC15 PIR32169
GH11J125068 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.9 +118.3 118271 8.2 HDGF PKNOX1 FOXA2 ARNT ARID4B IRF4 SP5 ZNF592 KAT8 MEF2D SLC37A2 CCDC15 TMEM218 KRT18P59 ENSG00000255475 ROBO4 HEPACAM LOC105369549 TBRG1 PIR45309
GH11J125163 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 14.7 +213.3 213272 8.6 PKNOX1 FEZF1 GLIS2 ZNF213 ZNF143 ZNF202 SP3 RXRA TSHZ1 ZNF623 PKNOX2 CCDC15 MSANTD2 ENSG00000255475 LOC105369549 TMEM218 RNU6-321P STT3A ENSG00000254509 DDX25
GH11J125061 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 14.6 +108.8 108833 3.5 ZFP64 ARID4B SIN3A IRF4 ZNF48 YY1 GLIS2 ZNF207 ZNF143 ATF7 SLC37A2 CCDC15 ROBO3 GC11M125054 GC11M125045
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC15 gene promoter:

Genomic Locations for CCDC15 Gene

Genomic Locations for CCDC15 Gene
chr11:124,954,121-125,041,489
(GRCh38/hg38)
Size:
87,369 bases
Orientation:
Plus strand
chr11:124,824,017-124,911,385
(GRCh37/hg19)

Genomic View for CCDC15 Gene

Genes around CCDC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC15 Gene

Proteins for CCDC15 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P6D6-CCD15_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 15
    Protein Accession:
    Q0P6D6
    Secondary Accessions:
    • Q9H8U7

    Protein attributes for CCDC15 Gene

    Size:
    951 amino acids
    Molecular mass:
    110484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH18540.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for CCDC15 Gene

Protein Expression for CCDC15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC15 Gene

  • Ubiquitination at posLast=848848, Lys725, Lys595, posLast=443443, and posLast=128128
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC15 Gene

Domains & Families for CCDC15 Gene

Gene Families for CCDC15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC15: view

No data available for UniProtKB/Swiss-Prot for CCDC15 Gene

Function for CCDC15 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for CCDC15 Gene

genes like me logo Genes that share phenotypes with CCDC15: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC15 Gene

Localization for CCDC15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC15 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 3
cytosol 3
plasma membrane 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CCDC15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC15 Gene

Pathways & Interactions for CCDC15 Gene

SuperPathways for CCDC15 Gene

PathCards logo More details on SuperPathways for CCDC15
No Data Available

Interacting Proteins for CCDC15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341684%0d%0a9606.ENSP00000355250%0d%0a
Selected Interacting proteins: Q0P6D6-CCD15_HUMAN ENSP00000341684 for CCDC15 Gene via IID STRING

GPS-Prot Interaction Network for CCDC15

Gene Ontology (GO) - Biological Process for CCDC15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC15 Gene

Drugs & Compounds for CCDC15 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCDC15 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCDC15 Gene

(20) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(9) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC15 Gene

Coiled-coil domain containing 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC15 Gene

No ASD Table

Relevant External Links for CCDC15 Gene

GeneLoc Exon Structure for
CCDC15
ECgene alternative splicing isoforms for
CCDC15

Expression for CCDC15 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC15 Gene

mRNA expression in normal human tissues for CCDC15 Gene
mRNA expression by BioGPS for CCDC15 GenemRNA expression by GTEx for CCDC15 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC15 Gene

This gene is overexpressed in Testis (x10.9).

Protein differential expression in normal tissues from HIPED for CCDC15 Gene

This gene is overexpressed in Plasma (61.9) and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC15 Gene



Protein tissue co-expression partners for CCDC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC15 Gene:

CCDC15

SOURCE GeneReport for Unigene cluster for CCDC15 Gene:

Hs.287555
genes like me logo Genes that share expression patterns with CCDC15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC15 Gene

Orthologs for CCDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC15 34 33
  • 98.67 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CCDC15 34 33
  • 78.56 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CCDC15 34 33
  • 77.29 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ccdc15 16 34 33
  • 75.92 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc15 33
  • 73.92 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 55 (a)
 OneToMany
-- 34
  • 46 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia CCDC15 34
  • 27 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCDC15 34 33
  • 57.51 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CCDC15 34
  • 39 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ccdc15 33
  • 58.4 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC100333818 33
  • 51.56 (n)
CCDC15 34
  • 33 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 26 (a)
 OneToOne
Species where no ortholog for CCDC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC15 Gene

ENSEMBL:
Gene Tree for CCDC15 (if available)
TreeFam:
Gene Tree for CCDC15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC15: view image

Paralogs for CCDC15 Gene

No data available for Paralogs for CCDC15 Gene

Variants for CCDC15 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CCDC15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs386352386 uncertain-significance, not provided 124,987,126(+) G/C splice_acceptor_variant
rs1000034363 -- 124,970,186(+) C/G intron_variant
rs1000038016 -- 125,009,047(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000047309 -- 125,016,009(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000109721 -- 125,009,286(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC15 Gene

Variant ID Type Subtype PubMed ID
esv1770401 CNV deletion 17803354
esv2256616 CNV deletion 18987734
esv2479047 CNV deletion 19546169
esv2745189 CNV deletion 23290073
esv2745190 CNV deletion 23290073
esv2745191 CNV deletion 23290073
esv2745192 CNV deletion 23290073
esv2745193 CNV deletion 23290073
esv3548468 CNV deletion 23714750
esv996549 CNV deletion 20482838
nsv1054682 CNV gain 25217958
nsv1125537 CNV tandem duplication 24896259
nsv1138084 CNV deletion 24896259
nsv1144597 CNV deletion 24896259
nsv39015 CNV deletion 16902084
nsv520010 CNV loss 19592680
nsv957899 CNV deletion 24416366

Variation tolerance for CCDC15 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC15 Gene

Disorders for CCDC15 Gene

Additional Disease Information for CCDC15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC15 Gene

Publications for CCDC15 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  5. Proximity interactions among centrosome components identify regulators of centriole duplication. (PMID: 24613305) Firat-Karalar EN … Stearns T (Current biology : CB 2014) 3 58

Products for CCDC15 Gene

Sources for CCDC15 Gene

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