Aliases for CCDC149 Gene

Aliases for CCDC149 Gene

  • Coiled-Coil Domain Containing 149 2 3 5
  • Coiled-Coil Domain-Containing Protein 149 3 4
  • DKFZp761B107 2
  • CCDC149 5

External Ids for CCDC149 Gene

Previous GeneCards Identifiers for CCDC149 Gene

  • GC04M024418
  • GC04M024437
  • GC04M024809
  • GC04M024150

Summaries for CCDC149 Gene

GeneCards Summary for CCDC149 Gene

CCDC149 (Coiled-Coil Domain Containing 149) is a Protein Coding gene.

Additional gene information for CCDC149 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC149 Gene

Genomics for CCDC149 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC149 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J024911 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 617.3 +67.7 67703 2.2 KDM1A FOXA1 SP1 POLR2A GTF2F1 ZFX MNT SP2 CTBP1 ZNF316 CCDC149 lnc-LGI2-2 piR-33432-368 SOD3
GH04J024978 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 620.9 +0.7 669 2.1 CTCF ZNF143 REST RAD21 SP1 TRIM22 EZH2 ZNF444 SMC3 NR2F2 CCDC149 lnc-SOD3-3 piR-60146-125 DHX15 LOC102723675 SOD3
GH04J024973 Promoter/Enhancer 1.1 FANTOM5 Ensembl ENCODE 7.8 +6.2 6188 2 CEBPG GATAD2A SP1 CEBPA CEBPB ZFX SPI1 ZBTB40 TEAD3 ZNF580 LOC102723675 CCDC149 DHX15 piR-40110-513 SOD3
GH04J024777 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 10.5 +201.4 201403 2.4 JUND CEBPB BHLHE40 SPI1 POLR2A CCDC149 SOD3 HNRNPA1P65 DHX15
GH04J024927 Enhancer 0.5 FANTOM5 Ensembl 14.6 +51.4 51403 4.8 CEBPB SPI1 CCDC149 LGI2 piR-33432-368 lnc-LGI2-2 SOD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC149 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC149

Top Transcription factor binding sites by QIAGEN in the CCDC149 gene promoter:
  • AhR
  • Arnt
  • CP2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LCR-F1

Genomic Locations for CCDC149 Gene

Genomic Locations for CCDC149 Gene
chr4:24,803,514-24,980,204
(GRCh38/hg38)
Size:
176,691 bases
Orientation:
Minus strand
chr4:24,807,739-24,981,826
(GRCh37/hg19)
Size:
174,088 bases
Orientation:
Minus strand

Genomic View for CCDC149 Gene

Genes around CCDC149 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC149 Gene

Proteins for CCDC149 Gene

  • Protein details for CCDC149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUS6-CC149_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 149
    Protein Accession:
    Q6ZUS6
    Secondary Accessions:
    • A6NJE7
    • B4DK90
    • B4DZG3
    • G5EA04
    • Q6NW41
    • Q8N3K8

    Protein attributes for CCDC149 Gene

    Size:
    474 amino acids
    Molecular mass:
    52796 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57761.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH67735.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC86142.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC86142.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC149 Gene

neXtProt entry for CCDC149 Gene

Post-translational modifications for CCDC149 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC149 Gene

Domains & Families for CCDC149 Gene

Gene Families for CCDC149 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC149 Gene

Suggested Antigen Peptide Sequences for CCDC149 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 149 (CC149_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZUS6

UniProtKB/Swiss-Prot:

CC149_HUMAN :
  • Belongs to the CCDC149 family.
Family:
  • Belongs to the CCDC149 family.
genes like me logo Genes that share domains with CCDC149: view

Function for CCDC149 Gene

Phenotypes From GWAS Catalog for CCDC149 Gene

genes like me logo Genes that share phenotypes with CCDC149: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC149

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC149 Gene

Localization for CCDC149 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC149 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC149 Gene

Pathways & Interactions for CCDC149 Gene

PathCards logo

SuperPathways for CCDC149 Gene

No Data Available

Interacting Proteins for CCDC149 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000425715 Q6ZUS6-CC149_HUMAN for CCDC149 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC149 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC149 Gene

Drugs & Compounds for CCDC149 Gene

No Compound Related Data Available

Transcripts for CCDC149 Gene

mRNA/cDNA for CCDC149 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC149

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC149 Gene

No ASD Table

Relevant External Links for CCDC149 Gene

GeneLoc Exon Structure for
CCDC149

Expression for CCDC149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC149 Gene

Protein differential expression in normal tissues from HIPED for CCDC149 Gene

This gene is overexpressed in Islet of Langerhans (46.0), Heart (17.0), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC149 Gene



Protein tissue co-expression partners for CCDC149 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC149

SOURCE GeneReport for Unigene cluster for CCDC149 Gene:

Hs.106432
genes like me logo Genes that share expression patterns with CCDC149: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC149 Gene

Orthologs for CCDC149 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC149 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC149 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC149 30 31
  • 89.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC149 30 31
  • 85.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc149 30
  • 82.63 (n)
Mouse
(Mus musculus)
Mammalia Ccdc149 30 17 31
  • 82.06 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCDC149 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC149 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC149 30 31
  • 75.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC149 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc149 30
  • 68.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc149a 30 31
  • 65.81 (n)
OneToMany
ccdc149b 31
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG14868 31
  • 27 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F29G6.2 31
  • 24 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6413 31
  • 43 (a)
OneToOne
Species where no ortholog for CCDC149 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCDC149 Gene

ENSEMBL:
Gene Tree for CCDC149 (if available)
TreeFam:
Gene Tree for CCDC149 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC149: view image

Paralogs for CCDC149 Gene

No data available for Paralogs for CCDC149 Gene

Variants for CCDC149 Gene

Additional dbSNP identifiers (rs#s) for CCDC149 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC149 Gene

Variant ID Type Subtype PubMed ID
esv2023485 CNV deletion 18987734
esv2499911 CNV deletion 19546169
esv2658939 CNV deletion 23128226
esv2727306 CNV deletion 23290073
esv27291 CNV loss 19812545
esv3333123 CNV insertion 20981092
esv3412 CNV loss 18987735
esv3599949 CNV loss 21293372
esv3599950 CNV loss 21293372
esv3599951 CNV loss 21293372
nsv1114499 CNV deletion 24896259
nsv1145027 CNV deletion 24896259
nsv593827 CNV loss 21841781
nsv829887 CNV gain+loss 17160897
nsv829888 CNV gain 17160897

Variation tolerance for CCDC149 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.70; 96.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC149 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC149 Gene

Disorders for CCDC149 Gene

Additional Disease Information for CCDC149

No disorders were found for CCDC149 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC149 Gene

Publications for CCDC149 Gene

  1. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PMID: 17457313) Christoforou A … Evans KL (Molecular psychiatry 2007) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3
  4. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3

Products for CCDC149 Gene

Sources for CCDC149 Gene