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Aliases for CCDC149 Gene

Aliases for CCDC149 Gene

  • Coiled-Coil Domain Containing 149 2 3 5

External Ids for CCDC149 Gene

Previous GeneCards Identifiers for CCDC149 Gene

  • GC04M024418
  • GC04M024437
  • GC04M024150

Summaries for CCDC149 Gene

GeneCards Summary for CCDC149 Gene

CCDC149 (Coiled-Coil Domain Containing 149) is a Protein Coding gene.

Additional gene information for CCDC149 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC149 Gene

Genomics for CCDC149 Gene

GeneHancer (GH) Regulatory Elements for CCDC149 Gene

Promoters and enhancers for CCDC149 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I024911 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 567.3 +67.6 67579 2 GTF2F1 CLOCK TAF1 MAX SIN3A RAD21 YY1 E2F1 CTBP1 ZNF316 CCDC149 GC04P024947 GC04M024806
GH04I024978 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 571 +0.7 669 2.1 CTCF ZNF680 TAF1 JUN TRIM22 MAX REST RAD21 NR2F2 POLR2A CCDC149 LOC102723675 DHX15 GC04P024947 GC04M024941
GH04I025088 Enhancer 0.8 Ensembl 11.6 -108.5 -108497 0.6 HDAC1 PKNOX1 TCF12 EGR1 ATF7 MEF2D SMARCA4 GMEB1 IKZF1 KDM1A CCDC149 LGI2 SEL1L3 GC04M024941 LOC105374534
GH04I024973 Enhancer 1.1 FANTOM5 Ensembl ENCODE 7.8 +6.1 6088 2.2 GATAD2A CEBPB CEBPG ZBTB40 TEAD3 E2F1 CEBPA ZKSCAN8 ZFX CCDC149 DHX15 GC04P024947 GC04M024941
GH04I025153 Enhancer 0.8 ENCODE 10 -174.7 -174704 3 ELF3 FOXA2 ARID4B RAD21 YY1 MIXL1 RXRA REST PPARG RFX3 ANAPC4 CCDC149 PI4K2B SEPSECS PIR60918
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC149 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC149 gene promoter:

Genomic Locations for CCDC149 Gene

Genomic Locations for CCDC149 Gene
174,088 bases
Minus strand

Genomic View for CCDC149 Gene

Genes around CCDC149 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC149 Gene

Proteins for CCDC149 Gene

  • Protein details for CCDC149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 149
    Protein Accession:
    Secondary Accessions:
    • A6NJE7
    • B4DK90
    • B4DZG3
    • G5EA04
    • Q6NW41
    • Q8N3K8

    Protein attributes for CCDC149 Gene

    474 amino acids
    Molecular mass:
    52796 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH57761.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH67735.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86142.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86142.1; Type=Frameshift; Positions=30; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC149 Gene

neXtProt entry for CCDC149 Gene

Post-translational modifications for CCDC149 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC149 Gene

Domains & Families for CCDC149 Gene

Gene Families for CCDC149 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CCDC149 Gene

Suggested Antigen Peptide Sequences for CCDC149 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC149 family.
  • Belongs to the CCDC149 family.
genes like me logo Genes that share domains with CCDC149: view

Function for CCDC149 Gene

Phenotypes From GWAS Catalog for CCDC149 Gene

Phenotypes for CCDC149 Gene

genes like me logo Genes that share phenotypes with CCDC149: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC149 Gene

Localization for CCDC149 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC149 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC149 Gene

Pathways & Interactions for CCDC149 Gene

SuperPathways for CCDC149 Gene

No Data Available

Interacting Proteins for CCDC149 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q6ZUS6-CC149_HUMAN ENSP00000374260 for CCDC149 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CCDC149 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC149 Gene

Drugs & Compounds for CCDC149 Gene

No Compound Related Data Available

Transcripts for CCDC149 Gene

Unigene Clusters for CCDC149 Gene

Coiled-coil domain containing 149:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC149 Gene

No ASD Table

Relevant External Links for CCDC149 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC149 Gene

Protein differential expression in normal tissues from HIPED for CCDC149 Gene

This gene is overexpressed in Islet of Langerhans (46.0), Heart (17.0), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC149 Gene

Protein tissue co-expression partners for CCDC149 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC149 Gene:


SOURCE GeneReport for Unigene cluster for CCDC149 Gene:

genes like me logo Genes that share expression patterns with CCDC149: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC149 Gene

Orthologs for CCDC149 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC149 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC149 33 34
  • 99.43 (n)
(Bos Taurus)
Mammalia CCDC149 33 34
  • 89.08 (n)
(Canis familiaris)
Mammalia CCDC149 33 34
  • 85.26 (n)
(Rattus norvegicus)
Mammalia Ccdc149 33
  • 82.63 (n)
(Mus musculus)
Mammalia Ccdc149 33 16 34
  • 82.06 (n)
(Monodelphis domestica)
Mammalia CCDC149 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC149 34
  • 70 (a)
(Gallus gallus)
Aves CCDC149 33 34
  • 75.55 (n)
(Anolis carolinensis)
Reptilia CCDC149 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc149 33
  • 68.46 (n)
(Danio rerio)
Actinopterygii ccdc149a 33 34
  • 65.81 (n)
ccdc149b 34
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14868 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea F29G6.2 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6413 34
  • 43 (a)
Species where no ortholog for CCDC149 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC149 Gene

Gene Tree for CCDC149 (if available)
Gene Tree for CCDC149 (if available)

Paralogs for CCDC149 Gene

No data available for Paralogs for CCDC149 Gene

Variants for CCDC149 Gene

Sequence variations from dbSNP and Humsavar for CCDC149 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000005494 -- 24,807,999(-) T/A/C 3_prime_UTR_variant
rs10000139 -- 24,870,759(-) C/T intron_variant
rs1000016712 -- 24,872,511(-) A/G intron_variant
rs1000069942 -- 24,886,644(-) C/T intron_variant
rs1000078016 -- 24,906,640(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC149 Gene

Variant ID Type Subtype PubMed ID
esv2023485 CNV deletion 18987734
esv2499911 CNV deletion 19546169
esv2658939 CNV deletion 23128226
esv2727306 CNV deletion 23290073
esv27291 CNV loss 19812545
esv3333123 CNV insertion 20981092
esv3412 CNV loss 18987735
esv3599949 CNV loss 21293372
esv3599950 CNV loss 21293372
esv3599951 CNV loss 21293372
nsv1114499 CNV deletion 24896259
nsv1145027 CNV deletion 24896259
nsv593827 CNV loss 21841781
nsv829887 CNV gain+loss 17160897
nsv829888 CNV gain 17160897

Variation tolerance for CCDC149 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.70; 96.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC149 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC149 Gene

Disorders for CCDC149 Gene

Additional Disease Information for CCDC149

No disorders were found for CCDC149 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC149 Gene

Publications for CCDC149 Gene

  1. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PMID: 17457313) Christoforou A … Evans KL (Molecular psychiatry 2007) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for CCDC149 Gene

Sources for CCDC149 Gene

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